Potentiation of alkylating agents by NLCQ-1 or TPZ in vitro and in vivo [0.03%]
NLCQ-1或TPZ增敏烷基化剂的体内外研究
Maria V Papadopoulou,Xinhai Ji,William D Bloomer
Maria V Papadopoulou
Purpose: To investigate potential synergistic interactions between bioreductive agents, either NLCQ-1 or tirapazamine (TPZ) and two alkylating chemotherapeutic drugs, and how such interactions compare in vitro and in vivo...
Colostrinin decreases spontaneous and induced mutation frequencies at the hprt locus in Chinese hamster V79 cells [0.03%]
colostrinin降低中国地鼠V79细胞hprt位点的自发和诱导突变率
Attila Bacsi,Leopoldo Aguilera-Aguirre,Peter German et al.
Attila Bacsi et al.
Colostrinin (CLN), a uniform mixture of low-molecular weight, proline-rich polypeptides, induces neurite outgrowth of pheochromocytoma cells, extends the lifespan of diploid fibroblast cells, inhibits beta amyloid-induced apoptosis and resu...
John Fruehauf
John Fruehauf
There is strong evidence to support targeting the epidermal growth factor receptor (EGFR) for cancer therapy. Monoclonal antibodies targeting the ligand-binding region of the receptor and receptor tyrosine kinase inhibitors have shown promi...
Total and lipid-bound plasma sialic acid as diagnostic markers in colorectal cancer patients: correlation with cathepsin B expression in progression to Dukes stage [0.03%]
血清总己糖胺和脂结合涎酸诊断标志物在结直肠癌患者中的应用：与杜克斯分期恶变中溶酶体蛋白酶B的表达相关性分析
Tadeusz Sebzda,Yousif Saleh,Jakub Gburek et al.
Tadeusz Sebzda et al.
Purpose: Serum cathepsin B (CB), Total Sialic acid (TSA), total sialic acid (TSA) and lipid bound sialic acid (TSA) concentrations more useful than the other markers investigated for detecting different malignancies. Our ...
Identification of cysteine residues critically involved in homodimer formation and protein expression of human ATP-binding cassette transporter ABCG2: a new approach using the flp recombinase system [0.03%]
人ATP结合盒转运蛋白ABCG2的半胱氨酸残基同二聚体形成和蛋白质表达的关键作用鉴定：一种新的flp重组系统方法
Kanako Wakabayashi,Hiroshi Nakagawa,Tatsuhiko Adachi et al.
Kanako Wakabayashi et al.
Since ABCG2 is a half-transporter in the ATP-binding cassette (ABC) transporter family, it has been suspected that ABCG2 functions as a homodimer. In the present study, we have investigated the molecular mechanism underlying homodimer forma...
A new paradigm for the development of anticancer agents from natural products [0.03%]
天然产物抗癌药物研发的新范式
Balanehru Subramanian,Alexander Nakeff,Karen Tenney et al.
Balanehru Subramanian et al.
A novel pharmacology paradigm has been developed which quickly and efficiently moves prospective anticancer drugs from the discovery phase through pharmacology testing and into therapeutic trial assessment. Following discovery, the drug is ...
Vaccination with leukemia-loaded dendritic cells eradicates residual disease and prevent relapse [0.03%]
负载白血病的树突状细胞疫苗清除残余病灶并防止复发
Dorrah Deeb,Xiaohua Gao,Hao Jiang et al.
Dorrah Deeb et al.
We have previously demonstrated that TNF-alpha gene therapy with myeloid progenitor cells inhibits the progression of 32Dp210 myeloid leukemia in mice. Because TNF-alpha has been shown to induce the activation and maturation of dendritic ce...
Robert A Newman,Peiying Yang,Walter N Hittelman et al.
Robert A Newman et al.
While certain cardiac glycoside compounds such as oleandrin, bufalin and digitoxin are known to be associated with potent cytotoxicity to human tumor cells, the mechanisms by which this effect is produced are not clear. We now demonstrate t...
Human Flt3 ligand from Pichia pastoris inhibits growth of lymphoma and colon adenocarcinoma in mice [0.03%]
毕赤酵母表达的人类Flt3配体抑制淋巴瘤和结肠腺癌小鼠的生长
Yan-Li Zhang,Yi-Ju Wei,Yan-Chun Deng et al.
Yan-Li Zhang et al.
Potent effects of Flt3 ligand (FL) on the development of the immune system have generated much interest in application of FL in cancer immunotherapy. Objective: ...
Urease-induced alkalinization of extracellular pH and its antitumor activity in human breast and lung cancers [0.03%]
尿酶诱导的细胞外pH碱化及其在人类乳腺癌和肺癌中的抗肿瘤活性
Wah Yau Wong,Carl I DeLuca,Baomin Tian et al.
Wah Yau Wong et al.
Jack bean urease catalyzes the decomposition of urea into ammonia, which in turn increases the pH of the surrounding medium. Based on these two properties, we have investigated the antitumor effects of urease in vitro and in vivo on human l...