Genetic reduction of matriptase-1 expression is associated with a reduction in the aggressive phenotype of prostate cancer cells in vitro and in vivo [0.03%]
遗传学降低基质金属蛋白酶解活酶-1表达与体内外前列腺癌细胞侵略表型下降相关性研究
Andrew J Sanders,Christian Parr,Gaynor Davies et al.
Andrew J Sanders et al.
Purpose: Matriptase-1 has been implicated as playing an important role in various types of cancer progression through many different cancer related pathways. In the current study we assessed the efficacy of targeting matr...
Cytotoxic effects of leaf, stem and root extracts of Nerium oleander on leukemia cell lines and role of the p-glycoprotein in this effect [0.03%]
Nerium oleander的叶、茎和根提取物对白血病细胞系的细胞毒性作用及其在该作用中的p-糖蛋白的作用研究
Nevruz Turan,Kadriye Akgün-Dar,Serap Erdem Kuruca et al.
Nevruz Turan et al.
Nerium oleander (No), is a toxic plant. In recent studies, it was determined that the extracts of this plant are effective to treat some types of cancer, but these studies are limited and do not include human leukemia. In the present study,...
Cytotoxicity of different selective serotonin reuptake inhibitors (SSRIs) against cancer cells [0.03%]
不同选择性5-羟色胺再摄取抑制剂(SSRI)对癌细胞的细胞毒性作用比较研究
M Rosetti,M Frasnelli,A Tesei et al.
M Rosetti et al.
Cell membrane ion transporters expression and activity are altered in cancer cells and these phenotypic alterations offer potential targets for cancer therapies. Among the therapeutic agents affecting cell membrane transporters, serotonin r...
Rajesh L Thangapazham,Anuj Sharma,Jaya P Gaddipati et al.
Rajesh L Thangapazham et al.
The current therapy for prostate cancer includes radical prostatectomy, radiation therapy and hormonal ablation. Chemotherapy also provides beneficial results for some patients with advanced prostate cancer but with several harmful side eff...
Genetic polymorphisms of human ABC transporter ABCG2: development of the standard method for functional validation of SNPs by using the Flp recombinase system [0.03%]
人类ATP结合盒式转运蛋白ABCG2基因多态性及利用位点特异性重组酶系统鉴定其功能的标准化方法的发展研究
Ai Tamura,Kanako Wakabayashi,Yuko Onishi et al.
Ai Tamura et al.
The vector-mediated introduction of cDNA into mammalian cells by calcium phosphate co-precipitation or permeation with lipofectamine is widely used for the integration of cDNA into genomic DNA. However, integration of cDNA into the host's c...
Cholecalciferol (vitamin D3) and the retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) are synergistic for chemoprevention of prostate cancer [0.03%]
维生素D3与维甲酸N-(4-羟基苯基)视黄酰胺在化学预防前列腺癌中的增效作用研究
Erik J Tokar,Brooke B Ancrile,Richard J Ablin et al.
Erik J Tokar et al.
Prostate cancer, the most commonly diagnosed cancer among American men, develops slowly over many years. The long latent period of 20 to 30 years, involved in the multistep process of carcinogenesis, provides an important opportunity to blo...
Chemopreventive activity of a macrofungus Phellinus rimosus against N-nitrosodiethylamine induced hepatocellular carcinoma in rat [0.03%]
灵芝属药用菌对N-亚硝基二乙胺致大鼠肝细胞癌的化学预防作用
Thekkuttuparambil Ananthanarayanan Ajith,Kainoor Krishnankutty Janardhanan
Thekkuttuparambil Ananthanarayanan Ajith
Chemoprevention is an important alternative approach to control cancer. Chemical substances with multiple inhibitory properties would be a welcome addition to the class of chemopreventive drugs. In this study, we investigated the antioxidan...
Effects of perillyl alcohol and heat shock treatment in gene expression of human lung adenocarcinoma cell line A549 [0.03%]
脑卒中后血管性痴呆的防治进展研究
Juliana de Saldanha da Gama Fischer,Paulo Costa Carvalho,Cerli Rocha Gattass et al.
Juliana de Saldanha da Gama Fischer et al.
The K-Ras protein is found mutated in 42.4% of lung adenocarcinoma cases, evidencing its importance as a chemotherapeutic target. The Ras protein becomes functional after farnesylation, a post-transduction modification, allowing its attachm...
Benzyl isothiocyanate (BITC) induces apoptosis in ovarian cancer cells in vitro [0.03%]
苯乙基异硫氰酸盐(BITC)通过诱导细胞凋亡抑制体外卵巢癌细胞生长
Satyan Kalkunte,Narasimha Swamy,Don S Dizon et al.
Satyan Kalkunte et al.
Advanced ovarian cancer (OC) is not curable by surgery alone and chemotherapy is essential for its treatment. Isothiocyanates have been shown to inhibit carcinogen-induced tumorigenesis in animal models, yet no efforts have been made to det...
Preclinical evaluation of an anti-alpha5beta1 integrin antibody as a novel anti-angiogenic agent [0.03%]
α5β1整合素抗体抗血管生成作用的药理学研究
Vanitha Ramakrishnan,Vinay Bhaskar,Debbie A Law et al.
Vanitha Ramakrishnan et al.
Integrin alpha5beta1, the principal fibronectin receptor, is an important survival factor, playing a key role in angiogenesis. Angiogenesis is critical for tumor growth, and anti-angiogenic therapies have met clinical success. To validate t...