Anti-angiogenic effect of Biophytum sensitivum is exerted through its cytokine modulation activity and inhibitory activity against VEGF mRNA expression, endothelial cell migration and capillary tube formation [0.03%]
Biophytum sensitivum的抗血管生成作用是通过其细胞因子调节活性及抑制VEGFmRNA表达、内皮细胞迁移和毛细血管管腔形成而产生
Chandrasekharan Guruvayoorappan,Girija Kuttan
Chandrasekharan Guruvayoorappan
Angiogenesis is a crucial step essential for the growth, progression and metastasis of solid tumors. Substances produced by inflammatory cells, such as cytokines play an important role in the stimulation and progression of angiogenesis. In ...
Degenerate binding of tyrosinase peptides to MHC II Ad/Ed molecules [0.03%]
tyr酶肽与MHC II类分子Ad/Ed的退化结合
Abraham Mittelman,Guglielmo Lucchese,Angela Stufano et al.
Abraham Mittelman et al.
Recently we defined the tyrosinase233-247IPYWDWRDAEKCDIC peptide as the pentadecamer sequence hosting the linear determinant of the anti-tyrosinase MAb T311. In order to understand the molecular features that render epitopic the amino acid ...
Decrease of endogenous vascular endothelial growth factor may not affect glioma cell proliferation and invasion [0.03%]
内源性血管内皮生长因子降低可能不会影响胶质瘤细胞增殖和侵袭
Xin Hong,Feng Jiang,Steven N Kalkanis et al.
Xin Hong et al.
Vascular endothelial growth factor (VEGF) is abundantly produced by glioma cells especially glioblastoma, the most malignant form of astrocytoma. VEGF, a well known angiogenic factor, acts in a paracrine fashion on endothelial cells to deve...
Activation of Src by c-Met overexpression mediates metastatic properties of colorectal carcinoma cells [0.03%]
C-Met过表达活化Src介导结直肠癌细胞的转移性质
Matthew H Herynk,Jing Zhang,Nila U Parikh et al.
Matthew H Herynk et al.
Overexpression and/or activation of c-Met, the protein tyrosine kinase receptor for the hepatocyte growth factor/scatter factor (HGF/SF), and the protein tyrosine kinase, Src, have been implicated in the progression and metastasis of human ...
Follicle stimulating hormone receptor (FSHR) antagonist and epithelial ovarian cancer (EOC) [0.03%]
促卵泡激素受体（FSHR）拮抗剂与上皮性卵巢癌（EOC）
Chinmoy K Bose
Chinmoy K Bose
Introduction: Follicle stimulating hormone receptor (FSHR), a G-protein coupled receptor present in granulosa cell of ovary is a unique transmembrane molecule pivotal in ovulation process. Its agonist and antagonists has ...
A lipid-soluble iron chelator alters cell cycle regulatory protein binding in breast cancer cells compared to normal breast cells [0.03%]
一种脂溶性铁螯合剂可改变乳腺癌细胞与正常乳腺细胞的周期调节蛋白结合方式
Paula M B Pahl,Sara M Reese,Lawrence D Horwitz
Paula M B Pahl
The lipid-soluble iron chelator desferri-exochelin (D-Exo) causes reversible cell cycle arrest in normal human mammary epithelial cells (NHMEC) but triggers apoptotic cell death in human breast cancer cells. We studied the effects of iron c...
Simultaneous inhibition of COX-2 and 5-LOX activities augments growth arrest and death of premalignant and malignant human lung cell lines [0.03%]
同时抑制COX-2和5-LOX活性可增强人肺癌细胞系癌前病变和恶性病变的增殖停止和死亡
Claudia P Schroeder,Peiying Yang,Robert A Newman et al.
Claudia P Schroeder et al.
The arachidonic acid-metabolizing enzymes cyclooxygenase-2 (COX-2) or 5-lipoxygenase (5-LOX) are overexpressed during lung carcinogenesis and their end products (e.g.; PGE2, 5-HETE, and LTB4) have been implicated in tumor development. Recen...
Comments regarding: Benzyl isothiocyanate (BITC) induces apoptosis in ovarian cancer cells in vitro Kalkunte S, Swamy N, Dizon DS, Brard L. J Exp Ther Oncol.5(4):287-300, 2006 [0.03%]
关于苯甲基异硫氰酸盐(BITC)对卵巢癌细胞的诱导凋亡作用的观点Kalkunte S, Swamy N, Dizon DS, Brard L. J Exp Ther Oncol.5(4):287-300, 2006
Chinmoy K Bose
Chinmoy K Bose
Spontaneous unusual expression of frequency of chromosome aberrations and common fragile in human lymphocytes of colorectal cancer patients induced by Aphidicolin [0.03%]
秋水仙素诱导结直肠癌患者人淋巴细胞染色体畸变频率和常见脆性位点的自发异常表达现象
Ajit Kumar Saxena,C S Agarwal,Manoj Kumar et al.
Ajit Kumar Saxena et al.
Chromosomal fragile sites are distributed all over the human genome. Aphidicolin mediated expression frequency of common fragile sites and other chromosomal changes were evaluated in prometaphase/metaphase chromosomes obtained from peripher...
Somatic tissues degeneration [0.03%]
体组织退化
Dumitru Pavel
Dumitru Pavel