Organic extracts of Larrea divaricata Cav. induced apoptosis on tumoral MCF7 cells with an higher cytotoxicity than nordihydroguaiaretic acid or paclitaxel [0.03%]
拉雷亚灌木的有机提取物能诱导MCF7肿瘤细胞凋亡且其毒性高于 nordihydroguaiaretic acid 或是紫杉醇
Guillermina Bongiovanni,Juan Cantero,Aldo Eynard et al.
Guillermina Bongiovanni et al.
The methanolic and methane dichloride extracts of aerial parts of Larrea divaricata Cay. (Jarilla) plants exhibited a pronounced cytotoxic effect by arresting cell viability at a level of 35% against the MCF-7 cell line, a human breast aden...
Nrf2-dependent and -independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress [0.03%]
氧化应激下HepG2细胞中ABCC1、ABCC2和ABCG2的Nrf2依赖性和非依赖性诱导作用研究
Tatsuhiko Adachi,Hiroshi Nakagawa,Ivy Chung et al.
Tatsuhiko Adachi et al.
Nrf2, an NF-E2-related transcription factor, plays a critical role in transcriptional upregulation of many target genes, including those for metabolizing enzymes and transporters essential for cellular defense in response to oxidative and/o...
Development of polyclonal antibodies specific to ATP-binding cassette transporters human ABCG4 and mouse Abcg4: site-specific expression of mouse Abcg4 in brain [0.03%]
ABCG4多克隆抗体的开发及其在脑中的特异定位分布研究
Shoko Koshiba,Takehito Ito,Akira Shiota et al.
Shoko Koshiba et al.
In our recent study on seeking new mouse ATP-binding cassette (ABC) transporters of the G subfamily, we succeeded in cloning mouse Abcg4 from a cDNA library of mouse brain, and we characterized the tissue-specific expression and chromosomal...
Sanjay Goel,Manuel Hidalgo,Roman Perez-Soler
Sanjay Goel
The epidermal growth factor receptor (EGFR) plays an important role in the development and progression of solid tumors. Growing evidence suggests that EGFR activation also mediates resistance to chemotherapy and radiation therapy. Studies e...
The effect of Tc-99m-labeled MDM2 antisense oligonucleotide on gene expression in human breast cancer MCF-7 cells [0.03%]
抗肌瘤蛋白2反义寡核苷酸~(99m)Tc标记对人乳腺癌MCF-7细胞基因表达的影响研究
Changjiu Zhao,Peng Fu,Yunxia Sheng et al.
Changjiu Zhao et al.
To investigate the effect of radiolabed mouse double minute 2 (MDM2) antisense oligonucleotide on gene expression in human breast cancer MCF-7 cells, an antisense oligonucleotide (ASON) targeting MDM2 mRNA was synthesized and radiolabeled w...
Amentoflavone, a biflavonoid from Biophytum sensitivum augments lymphocyte proliferation, natural killer cell and antibody dependent cellular cytotoxicity through enhanced production of IL-2 and IFN-gamma and restrains serum sialic acid and gamma glutamyl transpeptidase production in tumor - bearing animals [0.03%]
Biophytum sensitivum中的双黄酮化合物Amentoflavone通过增强IL-2和IFN-γ的产生促进淋巴细胞增殖、自然杀伤细胞及抗体依赖性细胞细胞毒作用并限制肿瘤携带动物血清中唾液酸和γ谷氨酰胺转肽酶的生成
Chandrasekharan Guruvayoorappan,Girija Kuttan
Chandrasekharan Guruvayoorappan
Modulation of immune response is highly relevant in tumor cell destruction. The present study is focused on the effect of amentoflavone, a biflavonoid from Biophytum sensitivum on cell-mediated immune responses in normal and tumor-bearing c...
Active component of a GnRH based vaccine binds to natural GnRH receptors in Dunning R3327-G cell line and human prostate carcinoma vesicles [0.03%]
基于GnRH的疫苗活性成分能够结合Dunning R3327-G细胞系和人前列腺癌囊泡中的天然GnRH受体
Eddy Bover Fuentes,Franklin Fuentes Aguilar,Jesús Junco Barranco et al.
Eddy Bover Fuentes et al.
An alternative approach to immunization with native GnRH for the inhibition of gonadotropin secretion and gonadal function is the use of peptidomimetics such as peptides of GnRH that could serve as vaccines when these are joined to more imm...
Methyl jasmonate induced apoptosis in human prostate carcinoma cells via 5-lipoxygenase dependent pathway [0.03%]
茉莉酸甲酯通过5-脂氧合酶依赖途径诱导人前列腺癌细胞凋亡
Daniel E Ezekwudo,Robert C Wang,J Abiodun Elegbede
Daniel E Ezekwudo
Methyl jasmonate--a plant stress hormone with striking resemblance to lipoxygenase products have been reported to induce apoptosis in several cancers. However, 5-HETE--a product of the lipoxygenase pathway has been implicated in human prost...
Expression of the prostate transglutaminase (TGase-4) in prostate cancer cells and its impact on the invasiveness of prostate cancer [0.03%]
前列腺特异性组织_TRANSGLUTAMINASE-4在前列腺癌细胞中的表达及其对前列腺癌侵袭性的影响
Gaynor Davies,Richard J Ablin,Malcolm D Mason et al.
Gaynor Davies et al.
Background: Prostate transglutaminase (TGase-4), has been identified as a TGase that has a pattern of prostate specific expression. This study sought to determine (i) the level of TGase-4 in human cancer cell lines includ...
Feasible combination chemotherapy with nedaplatin and irinotecan for patients with non-small cell lung cancer and multiple high-risk factors [0.03%]
奈达铂联合伊立替康治疗多高危因素非小细胞肺癌患者的可行性研究
Fumihiro Oshita,Haruhiro Saito,Kouzo Yamada
Fumihiro Oshita
We retrospectively analyzed the outcome of high-risk patients with non-small cell lung cancer (NSCLC) treated with nedaplatin (NP) and irinotecan (CPT) combination chemotherapy. Between July 2002 and January 2006, 31 NSCLC patients with mul...