Pradeep Bugga,Milan Mrksich
Pradeep Bugga
The interactions of adherent cells with their insoluble extracellular matrices are complex and challenging to study in the laboratory. Approaches from interface science have been important to preparing models of the biological matrix wherei...
Rima Kandil,Olivia M Merkel
Rima Kandil
With its nearly unrestricted possibilities, gene therapy attracts more and more significance in modern-day research. The only issue still seeming to hold back its clinical success is the actual effective delivery of genetic material. Nuclei...
From electron crystallography of 2D crystals to MicroED of 3D crystals [0.03%]
从二维晶体的电子衍射到三维晶体的微晶电子衍射技术的发展
Michael W Martynowycz,Tamir Gonen
Michael W Martynowycz
Electron crystallography is widespread in material science applications, but for biological samples its use has been restricted to a handful of examples where two-dimensional (2D) crystals or helical samples were studied either by electron ...
Surfactant-induced Marangoni transport of lipids and therapeutics within the lung [0.03%]
表面活性剂诱发的肺内脂质和药物的马兰戈尼传输作用
Amy Z Stetten,Steven V Iasella,Timothy E Corcoran et al.
Amy Z Stetten et al.
Understanding the fundamentals of surface transport on thin viscous films has important application in pulmonary drug delivery. The human lung contains a large-area interface between its complex fluid lining and inhaled air. Marangoni flows...
Robert M Glaeser
Robert M Glaeser
It has become clear that the standard cartoon, in which macromolecular particles prepared for electron cryo-microscopy are shown to be surrounded completely by vitreous ice, often is not accurate. In particular, the standard picture does no...
The Light at the End of the Tunnel-Second Generation HPMA Conjugates for Cancer Treatment [0.03%]
隧道尽头的光芒-用于癌症治疗的新一代HPMA缀合物研究
Jiyuan Yang,Jindřich Kopeček
Jiyuan Yang
It is almost four decades since N-(2-hydroxypropyl)methacrylamide (HPMA) - based copolymers arose as drug carriers. Although fundamentals have been established and significant advantages have been proved, the commercialization of this platf...
Minjee Kang,Hojun Kim,Cecilia Leal
Minjee Kang
Lipids and nucleic acids (NAs) can hierarchically self-organize into a variety of nanostructures of increasingly complex geometries such as the 1D lamellar, 2D hexagonal, and 3D bicontinuous cubic phases. The diversity and complexity of tho...
Capillary suspensions: Particle networks formed through the capillary force [0.03%]
毛细管悬浮液：通过毛细作用力形成的颗粒网络
Erin Koos
Erin Koos
The addition of small amounts of a secondary fluid to a suspension can, through the attractive capillary force, lead to particle bridging and network formation. The capillary bridging phenomenon can be used to stabilize particle suspensions...
Inorganic Nanoparticles for Therapeutic Delivery: Trials, Tribulations and Promise [0.03%]
无机纳米颗粒药物传输体系：挑战，困境与前景
Gulen Yesilbag Tonga,Daniel F Moyano,Chang Soo Kim et al.
Gulen Yesilbag Tonga et al.
Inorganic nanomaterials have a wide array of physical and structural properties that make them attractive candidates for imaging and therapeutic delivery. Nanoparticle platforms have been intensely studied for these applications, and exampl...
Model cell membranes: Techniques to form complex biomimetic supported lipid bilayers via vesicle fusion [0.03%]
模型细胞膜：通过囊泡融合形成复杂的生物模拟支撑脂质双层的技术
Gregory J Hardy,Rahul Nayak,Stefan Zauscher
Gregory J Hardy
Vesicle fusion has long provided an easy and reliable method to form supported lipid bilayers (SLBs) from simple, zwitterionic vesicles on siliceous substrates. However, for complex compositions, such as vesicles with high cholesterol conte...