Siripen Kalayanarooj
Siripen Kalayanarooj
Dengue is one of the most important mosquito-borne viral illnesses. The first DHF outbreak was reported from the Philippines in 1953. Initially it was endemic only in Southeast Asia and the Western Pacific regions. After about 50 years from...
Nguyen Thi Phuong Lan,Kenji Hirayama
Nguyen Thi Phuong Lan
Epidemiological evidence indicates that host genetic factors are relevant and predispose DHF/DSS development. Here, we review the host genetic studies concerning human leucocyte antigens, antibody receptors, immune/inflammatory mediators, a...
Eiji Konishi
Eiji Konishi
Dengue fever (DF) and dengue hemorrhagic fever (DHF) are mosquito-transmitted diseases of global importance. Despite significant research efforts, no approved vaccines or antiviral drugs against these diseases are currently available. This ...
Lyre Anni Espada-Murao,Kouichi Morita
Lyre Anni Espada-Murao
Huge emphasis has been placed on the role of the adaptive immune system in dengue pathogenesis. Yet there is increasing evidence for the importance of the innate immune system in regulating dengue infection and possibly influencing the dise...
Ichiro Kurane,Takaji Matsutani,Ryuji Suzuki et al.
Ichiro Kurane et al.
Dengue virus (DENV) is a leading cause of morbidity and mortality in most tropical and subtropical areas of the world. Dengue virus infection induces specific CD4+CD8- and CD8+CD4- T cells in humans. In primary infection, T-cell responses t...
Dengue virus receptor [0.03%]
登革病毒受体
Kazuya I P J Hidari,Takashi Suzuki
Kazuya I P J Hidari
Dengue virus is an arthropod-borne virus transmitted by Aedes mosquitoes. Dengue virus causes fever and hemorrhagic disorders in humans and non-human primates. Direct interaction of the virus introduced by a mosquito bite with host receptor...
Quasispecies of dengue virus [0.03%]
登革病毒的类种群
Takeshi Kurosu
Takeshi Kurosu
Pathogenic viruses have RNA genomes that cause acute and chronic infections. These viruses replicate with high mutation rates and exhibit significant genetic diversity, so-called viral quasispecies. Viral quasispecies play an important role...
Yukiko Higa
Yukiko Higa
The distribution of dengue vectors, Ae. aegypti and Ae. albopictus, is affected by climatic factors. In addition, since their life cycles are well adapted to the human environment, environmental changes resulting from human activity such as...
Tomohiko Takasaki
Tomohiko Takasaki
Several dengue outbreaks occurred in Japan from 1942 to 1945. Dengue fever emerged in Nagasaki in August 1942 and soon spread to other cities such as Sasebo, Hiroshima, Kobe and Osaka, recurring every summer until 1945 and constituting the ...
Dengue, Urbanization and Globalization: The Unholy Trinity of the 21(st) Century [0.03%]
登革热、城市化和全球化：二十一世纪的三位一体危机
Duane J Gubler
Duane J Gubler
Dengue is the most important arboviral disease of humans with over half of the world's population living in areas of risk. The frequency and magnitude of epidemic dengue have increased dramatically in the past 40 years as the viruses and th...