Clinical Observation of Myocardial Contractility Modulation Device in Patients with Chronic Heart Failure [0.03%]
心力衰竭患者心脏收缩力调制装置的临床观察
Hongfei Song,Rui Yang,Wenwei Bai et al.
Hongfei Song et al.
Heart failure (HF) is one of the most common cardiovascular diseases in the 21st century, affecting more than 25 million individuals worldwide. According to estimates, 8.9 million cases have been reported in China alone. Although pharmacoth...
MiR-27b-3p Correlates with Arteriosclerosis Obliterans and Promotes the Proliferation and Migration of Arterial Smooth Muscle Cells by Targeting GAB1 [0.03%]
miR-27b-3p与动脉粥样硬化相关并通过靶向GAB1促进血管平滑肌细胞的增殖和迁移
Tuo Xu,Changwei Zheng,Yongkang Wu et al.
Tuo Xu et al.
Patients with atherosclerosis obliterans (ASO) are at risk of amputation or even death if timely treatment is not provided; current clinical treatments for ASO have certain disadvantages. This study aimed to ascertain the function of miR-27...
MiR-4429 Serves as a Protective Regulator by Targeting GNAI2 in Coronary Artery Disease [0.03%]
MicroRNA-4429通过靶向GNAI2在冠状动脉疾病中起到保护作用
Yu Chen,Siyuan Yang,Yifan Niu et al.
Yu Chen et al.
Increasingly evidence suggests that microRNA (miRNA) plays a pivotal role in coronary artery disease (CAD). This study investigated the abundance of miR-4429 in the serum of CAD patients and explored the function of miR-4429 and its target ...
Transcriptomic Analysis of the Heart Tissue in Spontaneously Hypertensive Rats Exposed to Acute Hypobaric Hypoxia [0.03%]
急性低氧暴露对 SHR 心脏组织转录组的影响及机制研究
Fengzhou Liu,Shiqiang Zhou,Yajuan Li et al.
Fengzhou Liu et al.
We evaluated the effect of acute hypobaric hypoxia (AHH) on the heart of early-stage spontaneously hypertensive male rats (SHRs). The rats were classified into a control (ground level; ~400 m altitude) group and an SHR-AHH experimental grou...
Long Non-Coding RNA NR_027324 Protects H9C2 Cells against Hypoglycemic and Hypoxic Injury by Interacting with microRNA-103-3p [0.03%]
长链非编码RNA NR_027324通过与微小核糖核酸-103-3p结合保护H9C2细胞免受缺糖和缺氧损伤
Qingkun Meng,Chengfu Wang,Yang Gao et al.
Qingkun Meng et al.
This study explored the relationship among lncRNA NR_027324, miR-103-3p, and autophagy-related protein 5 (ATG5) in cardiomyocytes under hypoglycemic/hypoxic conditions.Bioinformatics and luciferase assays were used to investigate the intera...
Identification and Validation of Calcium-Related Diagnostic Markers for Acute Myocardial Infarction via Bioinformatics Analysis and Machine Learning [0.03%]
基于生物信息学和机器学习的急性心肌梗死相关钙离子诊断标志物的鉴定与验证
Biao Wang,Jianhong Chen,Leili Wang et al.
Biao Wang et al.
The incidence of acute myocardial infarction (AMI) is increasing, and existing diagnostic techniques exhibit limited capacity for early AMI diagnosis. Given the robust association between Ca2+ levels and the AMI initiation, calcium-related ...
Renalase Ameliorates Myocardial Ischemia-Reperfusion Injury by Inhibiting Autophagy Through the Akt/mTOR Pathway [0.03%]
肾素通过Akt/mTOR信号通路抑制自噬来改善心肌缺血再灌注损伤
Ruixuan Li,Yuyan Wu,Xiexiong Zhao et al.
Ruixuan Li et al.
Evidence suggests that autophagy plays a crucial role in myocardial ischemia/reperfusion (I/R) injury. Renalase (RNLS) plays a protective role in cardiovascular diseases, including myocardial ischemia/reperfusion injury (MI/RI). Therefore, ...
METTL3 Modulates Autophagy by Targeting TFEB in Myocardial Hypertrophy [0.03%]
METTL3通过靶向TFEB调节心肌肥厚介导的自噬
Yanan Xie,Wei Jiao,Hongchao Wang et al.
Yanan Xie et al.
The aim of this study was to investigate the mechanism of m6A methylation in pathological myocardial hypertrophy (PMH), focusing on whether the methyltransferase METTL3 regulates the expression and nuclear translocation of the transcription...
A Cohort Study of Leisure Activities and Risk of Cardiometabolic Multimorbidity in Elderly Chinese [0.03%]
一项关于休闲活动与老年中国人代谢性多发病风险的队列研究
Jianan He,Xingyou Liu,Feiyue Feng et al.
Jianan He et al.
Cardiometabolic multimorbidity (CMM) is the co-occurrence of 2 or more cardiometabolic diseases, such as cardiovascular disease, stroke, diabetes, and hypertension. This study explores how leisure activities influence the risk of CMM in old...
Time Trends in the Disease Burden of Maternal Hypertensive Disorder in China from 1990 to 2021 [0.03%]
中国妊娠期高血压疾病疾病负担的时间趋势（1990-2021年）
Jing Wang,Zheng Liu,Jing Li
Jing Wang
Maternal hypertensive disorder (MHD) is one of the leading causes of maternal and perinatal mortality. With the adjustment of China's population policy and social development, identifying and monitoring the changing trends in the burden of ...