Ken&#x;ichiro Hayashi,Shinri Horoiwa,Kotaro Mori et al.
Ken&#x;ichiro Hayashi et al.
Inflammatory response induces phenotypic modulation of fibroblasts into myofibroblasts. Although transforming growth factor-βs (TGF-βs) evoke such transition, the details of the mechanism are still unknown. Here, we report that a LIM doma...
Jun-Ichi Sakamaki,Noboru Mizushima
Jun-Ichi Sakamaki
Protein-lipid conjugation is a widespread modification involved in many biological processes. Various lipids, including fatty acids, isoprenoids, sterols, glycosylphosphatidylinositol, sphingolipids, and phospholipids, are covalently linked...
A conserved WXXE motif is an apical delivery determinant of ABC transporter C subfamily isoforms [0.03%]
保守的WXXE基序是ABC转运蛋白C亚家族同工型向顶运送决定因子
Md Shajedul Haque,Yoshikazu Emi,Masao Sakaguchi
Md Shajedul Haque
ATP-binding cassette transporter isoform C7 (ABCC7), also designated as cystic fibrosis transmembrane conductance regulator (CFTR), is exclusively targeted to the apical plasma membrane of polarized epithelial cells. Although the apical loc...
A non-nucleotide agonist that binds covalently to cysteine residues of STING [0.03%]
与STING的半胱氨酸残基共价结合的非核苷酸激动剂
Kentaro Matsumoto,Shenwei Ni,Hiroyuki Arai et al.
Kentaro Matsumoto et al.
Stimulator of interferon genes (STING) is an ER-localized transmembrane protein and the receptor for 2',3'-cyclic guanosine monophosphate-adenosine monophosphate (cGAMP), which is a second messenger produced by cGAMP synthase (cGAS), a cyto...
Suppression of P-cadherin expression as a key regulatory element for embryonic stem cell stemness [0.03%]
P-钙粘着蛋白表达的抑制作为胚胎干细胞干性的关键调控元件
Yuka Takeda,Shuji Matsuguchi,Sae Nozaki et al.
Yuka Takeda et al.
In embryonic stem (ES) cell colonies, a small subpopulation that changes cell shape and loses pluripotency often appears in two-dimensional (2D) cultures, even in the presence of a stemness factor. We have previously shown that membrane tra...
Enhancement of Vivid-based photo-activatable Gal4 transcription factor in mammalian cells [0.03%]
基于Vivid的光活化Gal4转录因子在哺乳动物细胞中的增强效应
Shinji C Nagasaki,Tomonori D Fukuda,Mayumi Yamada et al.
Shinji C Nagasaki et al.
The Gal4/UAS system is a versatile tool to manipulate exogenous gene expression of cells spatially and temporally in many model organisms. Many variations of light-controllable Gal4/UAS system are now available, following the development of...
Role of phosphatidylserine in the localization of cell surface membrane proteins in yeast [0.03%]
磷脂酰丝氨酸在酵母细胞表面膜蛋白定位中的作用
Ryutaro Kashikuma,Makoto Nagano,Hiroki Shimamura et al.
Ryutaro Kashikuma et al.
Phosphatidylserine (PS) is a constituent of the cell membrane, being especially abundant in the cytoplasmic leaflet, and plays important roles in a number of cellular functions, including the formation of cell polarity and intracellular ves...
Reconstitution of functional tight junctions with individual claudin subtypes in epithelial cells [0.03%]
在上皮细胞中用单独的Claudin亚型重构功能性紧密连接
Mikio Furuse,Daiki Nakatsu,Wendy Hempstock et al.
Mikio Furuse et al.
The claudin family of membrane proteins is responsible for the backbone structure and function of tight junctions (TJs), which regulate the paracellular permeability of epithelia. It is thought that each claudin subtype has its own unique f...
Quantitative 3D correlative light and electron microscopy of organelle association during autophagy [0.03%]
自噬过程中细胞器关联的定量三维光电子相关显微镜观察
Satoru Takahashi,Chieko Saito,Ikuko Koyama-Honda et al.
Satoru Takahashi et al.
In macroautophagy, disk-shaped double-membrane structures called phagophores elongate to form cup-shaped structures, becoming autophagosomes upon closure. These autophagosomes then fuse with lysosomes to become autolysosomes and degrade eng...
PRL stimulates mitotic errors by suppressing kinetochore-localized activation of AMPK during mitosis [0.03%]
PRL通过在有丝分裂期间抑制着丝粒定位的AMPK活化来刺激有丝分裂错误
Kajung Ryu,Atsushi Yoshida,Yosuke Funato et al.
Kajung Ryu et al.
Phosphatase of regenerating liver (PRL) is frequently overexpressed in various malignant cancers and is known to be a driver of malignancy. Here, we demonstrated that PRL overexpression causes mitotic errors that accompany spindle misorient...