Lysosomal membrane integrity in fibroblasts derived from patients with Gaucher disease [0.03%]
Gaucher病患者来源的成纤维细胞溶酶体膜完整性的改变
Asuka Hamamoto,Natsuki Kita,Siddabasave Gowda B Gowda et al.
Asuka Hamamoto et al.
Gaucher disease (GD) is a recessively inherited lysosomal storage disorder characterized by a deficiency of lysosomal glucocerebrosidase (GBA1). This deficiency results in the accumulation of its substrate, glucosylceramide (GlcCer), within...
Coronin-1 promotes directional cell rearrangement in Drosophila wing epithelium [0.03%]
冠蛋白1通过促进斑翅果蝇表皮细胞的极性重排来抑制细菌感染引起的过度炎症反应
Keisuke Ikawa,Souta Hiro,Shu Kondo et al.
Keisuke Ikawa et al.
Directional cell rearrangement is a critical process underlying correct tissue deformation during morphogenesis. Although the involvement of F-actin regulation in cell rearrangement has been established, the role and regulation of actin bin...
Significance of the p38MAPK-CRP2 axis in myofibroblastic phenotypic transition [0.03%]
p38MAPK-CRP2轴在肌成纤维细胞表型转变中的意义
Ken&#x;ichiro Hayashi,Reuben Jacob Labios,Tsuyoshi Morita et al.
Ken&#x;ichiro Hayashi et al.
We have recently demonstrated that a LIM domain protein, cysteine and glycine-rich protein 2 (CSRP2 [CRP2]), plays a vital role in the functional expression of myofibroblasts and cancer-associated fibroblasts. CRP2 binds directly to myocard...
Visual quantification of prostaglandin E2 discharge from a single cell [0.03%]
单细胞前列腺素E2释放的可视化量化方法研究
Tetsuya Watabe,Shinya Yamahira,Michiyuki Matsuda et al.
Tetsuya Watabe et al.
Calcium transients drive cells to discharge prostaglandin E2 (PGE2). We visualized PGE2-induced protein kinase A (PKA) activation and quantitated PGE2 secreted from a single cell by combining fluorescence microscopy and a simulation model. ...
Rab32 and Rab38 maintain bone homeostasis by regulating intracellular traffic in osteoclasts [0.03%]
Rab32和Rab38通过调节破骨细胞内的细胞运输来维持骨稳态
Kanako Tokuda,Shiou-Ling Lu,Zidi Zhang et al.
Kanako Tokuda et al.
Osteoclasts play a crucial role in bone homeostasis by forming resorption pits on bone surfaces, resulting in bone resorption. The osteoclast expression of Rab38 protein is highly induced during differentiation from macrophages. Here we gen...
Signal sequence-triage is activated by translocon obstruction sensed by an ER stress sensor IRE1α [0.03%]
内质网压力感应器IRE1α感应到转位孔通道阻塞激活信号肽序列分类装置
Ashuei Sogawa,Ryota Komori,Kota Yanagitani et al.
Ashuei Sogawa et al.
Secretory pathway proteins are cotranslationally translocated into the endoplasmic reticulum (ER) of metazoan cells through the protein channel, translocon. Given that there are far fewer translocons than ribosomes in a cell, it is essentia...
VAMP5 and distinct sets of cognate Q-SNAREs mediate exosome release [0.03%]
VAMP5和一组相应的Q-SNARE介导外体释放
Takahide Matsui,Yuriko Sakamaki,Shu Hiragi et al.
Takahide Matsui et al.
Small extracellular vesicles (sEVs) are largely classified into two types, plasma-membrane derived sEVs and endomembrane-derived sEVs. The latter type (referred to as exosomes herein) is originated from late endosomes or multivesicular bodi...
IC2 participates in the cooperative activation of outer arm dynein densely attached to microtubules [0.03%]
IC2参与外周臂动力臂的协同活化并密集附着在微管上
Yusuke Kondo,Tomoka Ogawa,Emiri Kanno et al.
Yusuke Kondo et al.
Ciliary outer-arm dynein (OAD) consists of heavy chains (HCs), intermediate chains (ICs), and light chains (LCs), of which HCs are the motor proteins that produce force. Studies using the green alga Chlamydomonas have revealed that ICs and ...
FilGAP, a GAP for Rac1, down-regulates invadopodia formation in breast cancer cells [0.03%]
filgap蛋白通过下调侵袭小体的形成抑制乳腺癌细胞侵袭力的研究
Koji Saito,Sakino Ozawa,Yosuke Chiba et al.
Koji Saito et al.
Invadopodia are protrusive structures that mediate the extracellular matrix (ECM) degradation required for tumor invasion and metastasis. Rho small GTPases regulate invadopodia formation, but the molecular mechanisms of how Rho small GTPase...
Sphingomyelin metabolism underlies Ras excitability for efficient cell migration and chemotaxis [0.03%]
鞘氨醇代谢作用确保Ras的兴奋性以实现高效的细胞迁移和趋化性
Da Young Shin,Hiroaki Takagi,Michio Hiroshima et al.
Da Young Shin et al.
In eukaryotic motile cells, the active Ras (Ras-GTP)-enriched domain is generated in an asymmetric manner on the cell membrane through the excitable dynamics of an intracellular signaling network. This asymmetric Ras signaling regulates pse...