Chemokine induces phase transition from non-directional to directional migration during angiogenesis [0.03%]
化学引诱素在血管生成过程中诱导从非定向到定向迁移的相变
Ning Gui,Keisuke Sako,Moe Fukumoto et al.
Ning Gui et al.
During angiogenesis, sprouting endothelial cells (ECs) migrate and eventually connect to target vessels to form new vessel branches. However, it remains unclear how these sprouting vessels migrate toward the target vessels in three-dimensio...
Macropinocytosis regulates cytokine expression through Erk signaling in LPS-stimulated macrophages [0.03%]
macropinocytosis通过Erk信号调节LPS刺激的巨噬细胞中的细胞因子表达
Li Wang,Yanan Li,Yuxin He et al.
Li Wang et al.
Macropinocytosis, a type of large-scale endocytosis process, is induced in macrophages by extracellular stimuli, including lipopolysaccharide (LPS). In addition to uptake function, emerging evidence supports a link between macropinocytosis ...
Capturing CDKs in Action: Live-Cell Biosensors Pioneer the New Frontiers in Cell Cycle Research [0.03%]
捕捉CDKs的实际动作：活细胞生物传感器开创了细胞周期研究的新领域
Sachiya Nakashima,Aika Toyama,Hironori Sugiyama et al.
Sachiya Nakashima et al.
Cyclin-dependent kinases (CDKs) orchestrate cell cycle progression through precise temporal control of substrate phosphorylation. While traditional biochemical approaches and phosphoproteomics have provided valuable insights into CDK-mediat...
Live imaging of paracrine signaling: Advances in visualization and tracking techniques [0.03%]
旁分泌信号的活体成像：可视化和追踪技术的进步
Eriko Deguchi,Michiyuki Matsuda,Kenta Terai
Eriko Deguchi
Live imaging techniques have revolutionized our understanding of paracrine signaling, a crucial form of cell-to-cell communication in biological processes. This review examines recent advances in visualizing and tracking paracrine factors t...
Tango1L but not Tango1S, Tali and cTAGE5 is required for export of type II collagen in medaka fish [0.03%]
斑马鱼Tango1L而非Tango1S、Tali和cTAGE5参与II型胶原蛋白的跨内质网输出过程
Yusuke Yasuda,Tomoka Yoshida,Mahiro Oue et al.
Yusuke Yasuda et al.
Newly synthesized proteins destined for the secretory pathway are folded and assembled in the endoplasmic reticulum (ER) and then transported to the Golgi apparatus via COPII vesicles, which are normally 60-90 nm. COPII vesicles must accord...
The Role of Primary Cilia in Myoblast Proliferation and Cell Cycle Regulation during Myogenesis [0.03%]
原肌细胞生成过程中初级纤毛在肌管增殖和细胞周期调节中的作用
Zhichao Wu,Nuo Chen,Daisuke Takao
Zhichao Wu
The process of mammalian myogenesis is fundamental to understanding muscle development and holds broad relevance across multiple fields, from developmental biology to regenerative medicine. This review highlights two key aspects: myoblast p...
Impact of physiological ionic strength and crowding on kinesin-1 motility [0.03%]
生理离子强度和拥挤对动力蛋白酶运动的影响
Misaki Sagawa,Kazuhiro Oiwa,Hiroaki Kojima et al.
Misaki Sagawa et al.
The motility of biological molecular motors has typically been analyzed by in vitro reconstitution systems using motors isolated and purified from organs or expressed in cultured cells. The behavior of biomolecular motors within cells has f...
Magnetic control of membrane damage in early endosomes using internalized magnetic nanoparticles [0.03%]
利用内化磁性纳米颗粒在早期胞吞小体中实现膜损伤的磁控制
Yuta Yonekawa,Kazuki Oikawa,Boldbaatar Bayarkhuu et al.
Yuta Yonekawa et al.
Membrane stiffness is essential for cell migration, tumorigenesis, and development; however, the physical properties of intracellular membrane are poorly characterized. In this study, we internalized 20 nm magnetic nanoparticles (MNPs) into...
A sensitive ERK fluorescent probe reveals the significance of minimal EGF-induced transcription [0.03%]
一种灵敏的ERK荧光探针揭示了极少量EGF诱导的转录的意义
Zhang Weisheng,Jun Nakayama,Yukino Inomata et al.
Zhang Weisheng et al.
Extracellular signal-regulated kinase (ERK) regulates multiple cellular functions through distinct activation patterns. Genetically encoded fluorescent probes are instrumental in dissecting the ERK activity dynamics in living cells. Here we...
Multi-color fluorescence live-cell imaging in Dictyostelium discoideum [0.03%]
多重荧光活细胞成像在Dictyostelium discoideum中的应用
Hidenori Hashimura,Satoshi Kuwana,Hibiki Nakagwa et al.
Hidenori Hashimura et al.
The cellular slime mold Dictyostelium discoideum, a member of the Amoebozoa, has been extensively studied in cell and developmental biology. D. discoideum is unique in that they are genetically tractable, with a wealth of data accumulated o...