Soluble form of heparin-binding EGF-like growth factor contributes to retinoic acid-induced epidermal hyperplasia [0.03%]
可溶性基质金属蛋白酶衍生的表皮生长因子样生长因子促进维甲酸诱导的表皮增生
Rina Kimura,Ryo Iwamoto,Eisuke Mekada
Rina Kimura
Heparin-binding EGF-like growth factor (HB-EGF), a member of the EGF-family, is thought to be important for keratinocyte functions. HB-EGF is first synthesized as a membrane-anchored form, and its soluble form is released by ectodomain shed...
Defining the roles of beta-catenin and plakoglobin in cell-cell adhesion: isolation of beta-catenin/plakoglobin-deficient F9 cells [0.03%]
β-catenin和plakoglobin在细胞粘附中的作用：分离出不含β-catenin/Plakoglobin的F9细胞
Yoshitaka Fukunaga,Huijie Liu,Masayuki Shimizu et al.
Yoshitaka Fukunaga et al.
F9 teratocarcinoma cells in which beta-catenin and/or plakoglobin genes are knocked-out were generated and investigated in an effort to define the role of beta-catenin and plakoglobin in cell adhesion. Loss of beta-catenin expression only d...
A fission yeast SNAP-25 homologue, SpSec9, is essential for cytokinesis and sporulation [0.03%]
芽裂酵母的SNAP-25同源物SpSec9对细胞分裂和孢子形成是必不可少的
Taro Nakamura,Jun Kashiwazaki,Chikashi Shimoda
Taro Nakamura
The soluble NSF attachment protein 25 (SNAP-25) is a component of the SNARE complex that is essential for regulated exocytosis in diverse cell types. Here, we identified a fission yeast SNAP-25 homologue, SpSec9. The sec9+ gene was essentia...
Comparative Study
Cell structure and function. 2005;30(2):15-24. DOI:10.1247/csf.30.15 2005
Microtubule bundle formation and cell death induced by the human CLASP/Orbit N-terminal fragment [0.03%]
人类CLASP / Orbit氨基末端片段诱导的微管束形成和细胞死亡
Miki Aonuma,Mamiko Miyamoto,Yoshihiro H Inoue et al.
Miki Aonuma et al.
Previously we have identified the Drosophila orbit gene whose hypomorphic mutations cause abnormal chromosome segregation (Inoue et al., 2000). The orbit encodes Orbit/Mast, a 165-kDa microtubule-associated protein (MAP) with GTP-binding mo...
1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells [0.03%]
1，25-二羟基维生素D3通过抑制人早幼粒白血病细胞中翻译起始因子基因表达发挥抑瘤作用
Takuji Suzuki,Yu Koyama,Hiroyasu Ichikawa et al.
Takuji Suzuki et al.
The physiologically active metabolite of vitamin D(3), 1alpha,25-dihydroxyvitamin D(3) (DVD), is a potent inducer of cell differentiation in human myeloid leukemia cells. In the present study, we examined changes in gene expression during D...
Stimulator of interferon genes (STING) is an endoplasmic reticulum (ER)-localized transmembrane protein. STING induces the type I interferon and inflammatory responses against a variety of double-stranded DNA (dsDNA) viruses, which is criti...