Merkel cell-nerve cell interaction undergoes formation of a synapse-like structure in a primary culture [0.03%]
Merkel细胞-神经细胞相互作用通过形成类似突触的结构在原代培养中发生
Mineko Shimohira-Yamasaki,Shuji Toda,Yutaka Narisawa et al.
Mineko Shimohira-Yamasaki et al.
Merkel cells have been assumed to guide nerve fibers to the skin. However, there has been little in vitro evidence that supports this hypothesis, because there is no suitable established culture system of Merkel cells. Here we show that Mer...
Deficiency of the Caenorhabditis elegans DNA polymerase eta homologue increases sensitivity to UV radiation during germ-line development [0.03%]
芽丝虫DNA聚合酶η同源物的缺乏在胚系发育期间增加了紫外光的敏感性
Tsuyoshi Ohkumo,Chikahide Masutani,Toshihiko Eki et al.
Tsuyoshi Ohkumo et al.
Defects in the human XPV/POLH gene result in the variant form of the disease xeroderma pigmentosum (XP-V). The gene encodes DNA polymerase eta (Poleta), which catalyzes translesion synthesis (TLS) past UV-induced cyclobutane pyrimidine dime...
Cytoplasmic domain phosphorylation of heparin-binding EGF-like growth factor [0.03%]
肝素结合EGF样生长因子的细胞质结构域磷酸化作用
Xiaobiao Wang,Hiroto Mizushima,Satoshi Adachi et al.
Xiaobiao Wang et al.
Heparin-binding EGF-like growth factor (HB-EGF) is synthesized as a transmembrane precursor protein that is anchored to the plasma membrane. The extracellular EGF-like domain acts as a mitogen and motogen upon ectodomain shedding, but the f...
Ryo Iwamoto,Eisuke Mekada
Ryo Iwamoto
The epidermal growth factor (EGF)-ErbB signaling network is composed of multiple ligands of the EGF family and four tyrosine kinase receptors of the ErbB family. In higher vertebrates, these four receptors bind a multitude of ligands. Ligan...
Primary cilia of inv/inv mouse renal epithelial cells sense physiological fluid flow: bending of primary cilia and Ca2+ influx [0.03%]
实验证明鼠肾上皮细胞可感受生理流体流动：主纤毛弯曲及钙离子内流
Dai Shiba,Tetsuro Takamatsu,Takahiko Yokoyama
Dai Shiba
Primary cilia are hypothesized to act as a mechanical sensor to detect renal tubular fluid flow. Anomalous structure of primary cilia and/or impairment of increases in intracellular Ca2+ concentration in response to fluid flow are thought t...
Molecular dissection of internalization of Porphyromonas gingivalis by cells using fluorescent beads coated with bacterial membrane vesicle [0.03%]
利用细菌膜囊泡包被的荧光微球进行牙龈卟啉单胞菌内吞作用的分子解析研究
Kayoko Tsuda,Atsuo Amano,Kyohei Umebayashi et al.
Kayoko Tsuda et al.
Porphyromonas gingivalis is one of the causative agents of adult periodontitis, and has been reported to be internalized by nonphagocytic epithelial cells. However, the mechanism for the internalization remains unclear. In the present study...
Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1 [0.03%]
RanGAP1的磷酸化稳定其与Ran和RanBP1的相互作用
Eri Takeda,Miki Hieda,Jun Katahira et al.
Eri Takeda et al.
Ran is a nuclear Ras-like GTPase that is required for various nuclear events including the bi-directional transport of proteins and ribonucleoproteins through the nuclear pore complex, spindle formation, and reassembly of the nuclear envelo...
Comparative Study
Cell structure and function. 2005;30(2):69-80. DOI:10.1247/csf.30.69 2005
Molecular dissection of ARP1 regions required for nuclear migration and cell wall integrity checkpoint functions in Saccharomyces cerevisiae [0.03%]
芽囊酵母中ARP1调控核迁移和细胞壁完整性检查点的功能区域的分子解析
Ryoji Igarashi,Masaya Suzuki,Satoru Nogami et al.
Ryoji Igarashi et al.
The dynactin complex is one of the components required for the regulation of the cell wall integrity checkpoint, which ensures the completion of cell wall remodeling before mitosis. The core of the dynactin complex is a backbone filament co...
Comparative Study
Cell structure and function. 2005;30(2):57-67. DOI:10.1247/csf.30.57 2005
The role of mammalian Staufen on mRNA traffic: a view from its nucleocytoplasmic shuttling function [0.03%]
哺乳动物Staufen在mRNA运输中的作用及其核质穿梭功能分析
Takashi Miki,Keizo Takano,Yoshihiro Yoneda
Takashi Miki
The localization of mRNA in neuronal dendrites plays a role in both locally and temporally regulated protein synthesis, which is required for certain forms of synaptic plasticity. RNA granules constitute a dendritic mRNA transport machinery...
Jun Kashiwazaki,Taro Nakamura,Tomoko Iwaki et al.
Jun Kashiwazaki et al.
Ypt7p, a fission yeast (Schizosaccharomyces pombe) homologue of Rab7 GTPase, mediates fusion of endosomes to vacuoles and homotypic vacuole fusion. Here, we report that Ypt7p plays important roles in sporulation. Most ypt7Delta asci produce...