Structural truncation of IL-1R2 enhances the anti-inflammatory activity of HeLa cells [0.03%]
结构截短的IL-1R2增强HeLa细胞的抗炎活性
Isao Kato,Yoshiyuki Hagiwara,Masatake Asano et al.
Isao Kato et al.
Interleukin-1 receptor type 2 (IL-1R2) functions as a decoy receptor that suppresses IL-1-induced inflammatory signaling. Both membrane-bound IL-1R2 (WT IL-1R2) and its soluble form (sIL-1R2) bind interleukin-1α (IL-1α) at the cell surfac...
Context-dependent interactions among afadin, ZO-1, and actin filaments [0.03%]
AFADIN、闭锁蛋白和肌动蛋白丝之间的相互作用受环境影响
Yuji Nitta,Satoshi Urayama,Maki Kawashima et al.
Yuji Nitta et al.
Afadin and ZO-1 are actin-binding scaffold proteins localized at cell-cell junctions. Although these proteins contain multiple protein-binding motifs for various junctional proteins, their binding partners within cells are strictly regulate...
Monitoring phospholipid dynamics in vivo with a fluorescent dye octadecyl rhodamine B [0.03%]
用十八碳罗丹明B荧光染料对活体磷脂动力学进行监测研究
Li Hao,Caiyi Zhao,Kuninori Suzuki
Li Hao
Phospholipids are major components of biological membranes. They play an essential role in intracellular signaling and organelle dynamics; however, the availability of suitable lipid-specific probes is limited, which has hindered studies on...
Extracellular presentation of syntaxin4 as a potential trigger for region-specific gastrulation [0.03%]
Syntaxin4细胞外呈现可能是区域特异性原肠运动的触发因素
Sae Nozaki,Taisei Mihara,Yohei Hirai
Sae Nozaki
During early embryogenesis, gastrulation occurs within a specific region of the pluripotent epiblast, where cells undergo significant changes in their context. The induction of these cellular transformations in particular cell populations s...
Deep Learning-Based Segmentation of 2D Projection-Derived Overlapping Prospore Membrane in Yeast [0.03%]
基于深度学习的酵母二维投影衍生重叠prospore膜分割
Shodai Taguchi,Keita Chagi,Hiroki Kawai et al.
Shodai Taguchi et al.
Quantitative morphological analysis is crucial for understanding cellular processes. While 3D Z-stack imaging offers high-resolution data, the complexity of 3D structures makes direct interpretation and manual annotation challenging and tim...
Kento Kunihiro,Katsura Sano
Kento Kunihiro
As the outermost organ, the skin is particularly susceptible to physical damage. Keratinocytes are a major component of the epidermis, and their migration plays a crucial role in skin wound healing. Supersulfides contribute to energy produc...
Assembly and mother centriole recruitment of IFT-B subcomplexes to form IFT-B holocomplex [0.03%]
IFT-B亚复合物的组装及其与母中心粒的募集以形成IFT-B全蛋白 complexes
Koshi Tasaki,Yohei Katoh,Hye-Won Shin et al.
Koshi Tasaki et al.
For the biogenesis and maintenance of cilia, bidirectional protein trafficking within cilia is crucial, and is conducted by intraflagellar transport (IFT) trains containing the IFT-A and IFT-B complexes that are powered by dynein-2 and kine...
Tatsuki Tsuruoka,Yuhei Goto,Kazuhiro Aoki
Tatsuki Tsuruoka
p53 protein, a crucial transcription factor in cellular responses to a wide variety of stress, regulates multiple target genes involved in tumor suppression, senescence induction, and metabolic functions. To characterize the context-depende...
BiP, GRP94, Calreticulin and Calnexin Contribute to Development of the Notochord in Medaka Fish [0.03%]
斑马鱼中 BiP、GRP94、钙网蛋白和钙连蛋白参与脊索的发育
Serina Kita,Tokiro Ishikawa,Kazutoshi Mori
Serina Kita
The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to maintain the homeostasis of the ER. The UPR consists of the IRE1, PERK and ATF6 pathways in vertebrates. K...
A quantitative method to monitor STING degradation with dual-luciferase reporters [0.03%]
一种利用双报告基因监测STING降解的定量方法
Tsumugi Shoji,Kanako Sato,Ayumi Shinojima et al.
Tsumugi Shoji et al.
Stimulator of interferon genes (STING) triggers the type I interferon and inflammatory responses against a variety of DNA pathogens, which is essential to limiting viral infection and replication. STING activates the downstream kinase TBK1 ...