Extracellular presentation of syntaxin4 as a potential trigger for region-specific gastrulation [0.03%]
Syntaxin4细胞外呈现可能是区域特异性原肠运动的触发因素
Sae Nozaki,Taisei Mihara,Yohei Hirai
Sae Nozaki
During early embryogenesis, gastrulation occurs within a specific region of the pluripotent epiblast, where cells undergo significant changes in their context. The induction of these cellular transformations in particular cell populations s...
Deep Learning-Based Segmentation of 2D Projection-Derived Overlapping Prospore Membrane in Yeast [0.03%]
基于深度学习的酵母二维投影衍生重叠prospore膜分割
Shodai Taguchi,Keita Chagi,Hiroki Kawai et al.
Shodai Taguchi et al.
Quantitative morphological analysis is crucial for understanding cellular processes. While 3D Z-stack imaging offers high-resolution data, the complexity of 3D structures makes direct interpretation and manual annotation challenging and tim...
Kento Kunihiro,Katsura Sano
Kento Kunihiro
As the outermost organ, the skin is particularly susceptible to physical damage. Keratinocytes are a major component of the epidermis, and their migration plays a crucial role in skin wound healing. Supersulfides contribute to energy produc...
Assembly and mother centriole recruitment of IFT-B subcomplexes to form IFT-B holocomplex [0.03%]
IFT-B亚复合物的组装及其与母中心粒的募集以形成IFT-B全蛋白 complexes
Koshi Tasaki,Yohei Katoh,Hye-Won Shin et al.
Koshi Tasaki et al.
For the biogenesis and maintenance of cilia, bidirectional protein trafficking within cilia is crucial, and is conducted by intraflagellar transport (IFT) trains containing the IFT-A and IFT-B complexes that are powered by dynein-2 and kine...
Tatsuki Tsuruoka,Yuhei Goto,Kazuhiro Aoki
Tatsuki Tsuruoka
p53 protein, a crucial transcription factor in cellular responses to a wide variety of stress, regulates multiple target genes involved in tumor suppression, senescence induction, and metabolic functions. To characterize the context-depende...
BiP, GRP94, Calreticulin and Calnexin Contribute to Development of the Notochord in Medaka Fish [0.03%]
斑马鱼中 BiP、GRP94、钙网蛋白和钙连蛋白参与脊索的发育
Serina Kita,Tokiro Ishikawa,Kazutoshi Mori
Serina Kita
The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to maintain the homeostasis of the ER. The UPR consists of the IRE1, PERK and ATF6 pathways in vertebrates. K...
A quantitative method to monitor STING degradation with dual-luciferase reporters [0.03%]
一种利用双报告基因监测STING降解的定量方法
Tsumugi Shoji,Kanako Sato,Ayumi Shinojima et al.
Tsumugi Shoji et al.
Stimulator of interferon genes (STING) triggers the type I interferon and inflammatory responses against a variety of DNA pathogens, which is essential to limiting viral infection and replication. STING activates the downstream kinase TBK1 ...
Chemokine induces phase transition from non-directional to directional migration during angiogenesis [0.03%]
化学引诱素在血管生成过程中诱导从非定向到定向迁移的相变
Ning Gui,Keisuke Sako,Moe Fukumoto et al.
Ning Gui et al.
During angiogenesis, sprouting endothelial cells (ECs) migrate and eventually connect to target vessels to form new vessel branches. However, it remains unclear how these sprouting vessels migrate toward the target vessels in three-dimensio...
Macropinocytosis regulates cytokine expression through Erk signaling in LPS-stimulated macrophages [0.03%]
macropinocytosis通过Erk信号调节LPS刺激的巨噬细胞中的细胞因子表达
Li Wang,Yanan Li,Yuxin He et al.
Li Wang et al.
Macropinocytosis, a type of large-scale endocytosis process, is induced in macrophages by extracellular stimuli, including lipopolysaccharide (LPS). In addition to uptake function, emerging evidence supports a link between macropinocytosis ...
Capturing CDKs in Action: Live-Cell Biosensors Pioneer the New Frontiers in Cell Cycle Research [0.03%]
捕捉CDKs的实际动作：活细胞生物传感器开创了细胞周期研究的新领域
Sachiya Nakashima,Aika Toyama,Hironori Sugiyama et al.
Sachiya Nakashima et al.
Cyclin-dependent kinases (CDKs) orchestrate cell cycle progression through precise temporal control of substrate phosphorylation. While traditional biochemical approaches and phosphoproteomics have provided valuable insights into CDK-mediat...