Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes [0.03%]
动力蛋白依赖的自噬体运动介导其与溶酶体的有效融合
Shunsuke Kimura,Takeshi Noda,Tamotsu Yoshimori
Shunsuke Kimura
Autophagy is a membrane trafficking pathway that carries cytosolic components to the lysosome for degradation. During this process, the autophagosome, a double-membraned organelle, is generated de novo, sequesters cytoplasmic proteins and o...
Functional analysis of alpha5beta1 integrin and lipid rafts in invasion of epithelial cells by Porphyromonas gingivalis using fluorescent beads coated with bacterial membrane vesicles [0.03%]
荧光素标记的牙龈卟啉单胞菌膜囊泡包裹的荧光微球侵染上皮细胞功能分析及其机制研究
Kayoko Tsuda,Nobumichi Furuta,Hiroaki Inaba et al.
Kayoko Tsuda et al.
Porphyromonas gingivalis, a periodontal pathogen, was previously suggested to exploit alpha5beta1 integrin and lipid rafts to invade host cells. However, it is unknown if the functional roles of these host components are distinct from one a...
Recruitment of Tom1L1/Srcasm to endosomes and the midbody by Tsg101 [0.03%]
Tsg101募集Tom1L1/Srcasm到内吞小体和中体
Yuko Yanagida-Ishizaki,Tomomi Takei,Ray Ishizaki et al.
Yuko Yanagida-Ishizaki et al.
Tom1 (target of Myb 1) and its related proteins (Tom1L1/Srcasm and Tom1L2) constitute a protein family, which share an N-terminal VHS (Vps27, Hrs and STAM) domain and a following GAT (GGA and Tom1) domain. Tom1L1 has potential binding seque...
Mechanism of destruction of microtubule structures by 4-hydroxy-2-nonenal [0.03%]
4-羟基-2-壬烯醛破坏微管结构的机制研究
June Kokubo,Naoki Nagatani,Katsunori Hiroki et al.
June Kokubo et al.
A major end product of lipid peroxidation, 4-hydroxy-2-nonenal (HNE), is an electrophilic alkenal and produces Michael adducts with cellular proteins. It is known that exposure of cultured cells to HNE causes rapid disappearance of microtub...
ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum [0.03%]
ATF6是一种专门调控内质网质量控制蛋白的转录因子
Yusuke Adachi,Keisuke Yamamoto,Tetsuya Okada et al.
Yusuke Adachi et al.
Eukaryotic cells cope with endoplasmic reticulum (ER) stress by activating the unfolded protein response (UPR), a coordinated system of transcriptional and translational controls, which ensures the integrity of synthesized proteins. Mammali...
Phospholipase D is essential for keratocyte-like migration of NBT-II cells [0.03%]
磷脂酶D对NBT-II细胞类似角膜上皮细胞样迁移是必须的
Akira Nagasaki,Kimiko Inotsume,Masamitsu Kanada et al.
Akira Nagasaki et al.
NBT-II cells on collagen-coated substrates move rapidly and persistently, maintaining a semi-circular shape with a large lamellipodium, in a manner similar to fish keratocytes. The inhibitor of phospholipase D (PLD), n-butanol, completely b...
Different effects of all-trans-retinoic acid on phorbol ester-stimulated and phytohemagglutinin-stimulated interleukin-2 expression in human T-cell lymphoma HUT-78 cells [0.03%]
全反式维甲酸对佛波酯刺激和植物血凝素刺激的人T细胞淋巴瘤HUT-78细胞中白细胞介素-2表达的不同的效应
Shingo Goto,Norihisa Okada,Akihiro Kaneko et al.
Shingo Goto et al.
In view of the importance of vitamin A in the human immune system and the central role of interleukin-2 (IL-2) in the proliferation of T-lymphocytes, we examined the effects of all-trans-retinoic acid (ATRA) on the protein and gene expressi...
Gene expression and distribution of Swi6 in partial aneuploids of the fission yeast Schizosaccharomyces pombe [0.03%]
基因表达和酿酒酵母片段性染色体异常模型中的Swi6分布
Yuji Chikashige,Chihiro Tsutsumi,Kasumi Okamasa et al.
Yuji Chikashige et al.
Imbalances of gene expression in aneuploids, which contain an abnormal number of chromosomes, cause a variety of growth and developmental defects. Aneuploid cells of the fission yeast Schizosaccharomyces pombe are inviable, or very unstable...
Comparative Study
Cell structure and function. 2007;32(2):149-61. DOI:10.1247/csf.07036 2007
BDNF increases the phagocytic activity in cultured iris pigment epithelial cells [0.03%]
脑源性神经营养因子增加培养虹膜色素上皮细胞的吞噬活性
Hikari Yoshida,Hiroshi Tomita,Eriko Sugano et al.
Hikari Yoshida et al.
To investigate the effect of brain derived neurotrophic factor (BDNF) on the phagocytic activity in iris pigment epithelial (IPE) cells, purified porcine photoreceptor outer segments (POS) were applied to cultured IPE cells for three hours....
Hiroyuki Katayama,Akitsugu Yamamoto,Noboru Mizushima et al.
Hiroyuki Katayama et al.
Green fluorescent protein (GFP) from the jellyfish Aequorea victoria, its GFP variants (Aequorea GFPs), and more recently the novel GFP-like proteins from Anthozoa have greatly advanced our technologies for fluorescently labeling cells, org...