Expression of prolyl 3-hydroxylase genes in embryonic and adult mouse tissues [0.03%]
胚胎和成年小鼠组织中脯氨酰3-羟化酶基因的表达
Janice Vranka,H Scott Stadler,Hans Peter Bächinger
Janice Vranka
Collagen requires hydroxylation of its proline residues to achieve proper assembly, structure, and function. Prolyl 4-hydroxylase catalyzes formation of 4-hydroxyproline, which is essential for collagen triple helix formation and stability....
Comparative Study
Cell structure and function. 2009;34(2):97-104. DOI:10.1247/csf.09002 2009
Ectopic calcification is caused by elevated levels of serum inorganic phosphate in mdx mice [0.03%]
血清无机磷水平升高导致mdx小鼠异位钙化
Namiko Kikkawa,Tomohisa Ohno,Yosuke Nagata et al.
Namiko Kikkawa et al.
Ectopic calcification occurs in the skeletal muscle of mdx mice, a dystrophin-deficient animal model of Duchenne muscular dystrophy. The purpose of this study was to clarify the mechanism of the calcification. The calcified deposits were id...
TRFH domain is critical for TRF1-mediated telomere stabilization [0.03%]
TRFH结构域对端粒酶结合因子1稳定端粒的机制起关键作用
Keiji Okamoto,Yoichi Shinkai
Keiji Okamoto
The telomeres are nucleoprotein complexes essential for maintaining the genomic integrity of linear chromosomes. Six telomere localizing proteins form a complex named "shelterin/telosome" to cooperatively regulate telomere length and protec...
Yujian Lu,Zhenyu Wang,Liang Ge et al.
Yujian Lu et al.
The conserved protein Rod is found in various organisms. It is localized on the kinetochores or spindle microtubules during cell division. Rod is required for proper chromosome segregation during both mitosis and meiosis. The effects of rod...
Male germline stem cell division and spermatocyte growth require insulin signaling in Drosophila [0.03%]
胰岛素信号在果蝇雄性生殖系干细胞分裂及精原细胞发育中的作用
Satoru Ueishi,Hanako Shimizu,Yoshihiro H Inoue
Satoru Ueishi
Spermatogenesis in Drosophila commences with cell division of germline stem cells (GSCs) to produce male germline cells at the tip of the testis. However, molecular mechanisms inducing division of male GSCs have not been reported. Insulin-l...
Simultaneous single cell stable expression of 2-4 cDNAs in HeLaS3 using psiC31 integrase system [0.03%]
利用psi-C31整合酶系统在HeLaS3细胞中同时表达2-4个cDNA构建体
Fumiko Nishiumi,Takefumi Sone,Hiroe Kishine et al.
Fumiko Nishiumi et al.
An important consideration in the design of multigene delivery technology is the availability of suitable vectors to introduce multiple genes stably and stoichiometrically into living cells and co-express these genes efficiently. As a promi...
Novel function of transcription factor ATF5: blockade of p53-dependent apoptosis induced by ionizing irradiation [0.03%]
转录因子ATF5的新功能：阻断电离辐射诱发的p53依赖性凋亡作用
Takeshi Nishioka,Yusuke Miyai,Hisashi Haga et al.
Takeshi Nishioka et al.
Purpose: To find a new molecule that affects p53-dependent radiosensitivity. Methods and materials: A mouse sarcoma cell line, QRsP(p53...
Magnetic separation of human podocalyxin-like protein 1 (hPCLP1)-positive cells from peripheral blood and umbilical cord blood using anti-hPCLP1 monoclonal antibody and protein A expressed on bacterial magnetic particles [0.03%]
利用细菌磁颗粒表达的抗人podocalyxin样蛋白1单克隆抗体和蛋白质A从外周血和脐带血中磁性分离人podocalyxin样蛋白1阳性细胞
Motoki Kuhara,Tomoko Yoshino,Miho Shiokawa et al.
Motoki Kuhara et al.
Hemangioblasts are common progenitors of hematopoietic and angiogenic cells, which have been demonstrated in the mouse to possess a unique cell surface marker, podocalyxin-like protein 1 (PCLP1) (Hara, T. et al., Immunity, 11: 567-578. 1999...
Insufficient membrane fusion in dysferlin-deficient muscle fibers after heavy-ion irradiation [0.03%]
重离子照射后卵圆idine诱导的中心体分离导致微管组织中心功能紊乱
Mizuki Hino,Nobuyuki Hamada,Yuki Tajika et al.
Mizuki Hino et al.
Recently, SJL/J mice have been used as an animal model in studies of dysferlinopathy, a spectrum of muscle diseases caused by defects in dysferlin protein. In this study we irradiated muscle fibers isolated from skeletal muscle of SJL/J mic...
pXBP1(U), a negative regulator of the unfolded protein response activator pXBP1(S), targets ATF6 but not ATF4 in proteasome-mediated degradation [0.03%]
pXBP1(U)通过蛋白酶体介导的降解靶向作用于ATF6而不是ATF4，作为展开蛋白质反应激活物pXBP1(S)的负调节因子
Hiderou Yoshida,Aya Uemura,Kazutoshi Mori
Hiderou Yoshida
Cells from yeast to humans activate unconventional mRNA splicing when unfolded proteins accumulate in the endoplasmic reticulum (ER) under ER stress conditions. The substrate of this splicing in mammalian cells is XBP1 mRNA, which encodes t...