Artificial compounds differentially control Dictyostelium chemotaxis and cell differentiation [0.03%]
人工化合物选择性地控制Dictyostelium化学趋向性和细胞分化
Hidekazu Kuwayama,Haruhisa Kikuchi,Yoshiteru Oshima et al.
Hidekazu Kuwayama et al.
Differentiation-inducing factor-1 and -2 (DIF-1 and DIF-2) are small lipophilic signal molecules that control both cell differentiation and chemotaxis in the cellular slime mold Dictyostelium discoideum. In this study, we examined the effec...
Radiation-induced cancer cell repopulation: a possible mechanism implied by experiments using transplantable mouse-derived sarcoma cell line [0.03%]
辐射诱发癌细胞再群体化：移植小鼠肉瘤细胞系实验所提示的一种可能机制
Takeshi Nishioka,Motoaki Yasuda,Tsuguhide Takeshima et al.
Takeshi Nishioka et al.
Purpose: Treatment with any cytotoxic agent can trigger surviving cells in a tumor to divide faster than before. This phenomenon is widely recognized as "repopulation". To better clarify the mechanism, gene expression pro...
Dynamin 2 associates with microtubules at mitosis and regulates cell cycle progression [0.03%]
dynamin 2与微管在有丝分裂时相结合并调节细胞周期进展
Nobuhisa Ishida,Yuichi Nakamura,Kenji Tanabe et al.
Nobuhisa Ishida et al.
Dynamin, a ~100 kDa large GTPase, is known as a key player for membrane traffic. Recent evidence shows that dynamin also regulates the dynamic instability of microtubules by a mechanism independent of membrane traffic. As microtubules are h...
Luminal domain of ATF6 alone is sufficient for sensing endoplasmic reticulum stress and subsequent transport to the Golgi apparatus [0.03%]
ATF6的 luminal 域足以感应内质网压力并随后运输到高尔基体
Yoshimi Sato,Satomi Nadanaka,Tetsuya Okada et al.
Yoshimi Sato et al.
The transcription factor ATF6 is constitutively synthesized as a type II transmembrane protein embedded in the endoplasmic reticulum (ER). When unfolded proteins accumulate in the ER, ATF6 senses such ER stress via an as yet undetermined me...
A novel ER J-protein DNAJB12 accelerates ER-associated degradation of membrane proteins including CFTR [0.03%]
一种新的内质网J蛋白DNAJB12加速包括CFTR在内的膜蛋白的内质网关联降解
Yo-hei Yamamoto,Taiji Kimura,Shuku Momohara et al.
Yo-hei Yamamoto et al.
Cytosolic Hsc70/Hsp70 are known to contribute to the endoplasmic reticulum (ER)-associated degradation of membrane proteins. However, at least in mammalian cells, its partner ER-localized J-protein for this cellular event has not been ident...
Novel cis-acting element GASE regulates transcriptional induction by the Golgi stress response [0.03%]
新的顺式作用元件GASE调节高尔基体压力反应的转录诱导
Masaya Oku,Soichiro Tanakura,Aya Uemura et al.
Masaya Oku et al.
When increased production of secretory proteins overwhelms the capacity of the endoplasmic reticulum (ER) and the Golgi apparatus, eukaryotic cells expand their capacity to sustain secretory function. The capacity of the ER is enhanced by t...
Stability control of MTL1 mRNA by the RNA-binding protein Khd1p in yeast [0.03%]
酵母中RNA结合蛋白Khd1p通过MTL1 mRNA的稳定性调控其表达
Naoko Mauchi,Yoshiaki Ohtake,Kenji Irie
Naoko Mauchi
Khd1p (KH-domain protein 1) is a yeast RNA-binding protein highly homologous to mammalian hnRNP K. Khd1p associates with hundreds of potential mRNA targets including a bud-localized ASH1 mRNA and mRNAs encoding membrane-associated proteins ...
p120-Catenin is essential for N-cadherin-mediated formation of proper junctional structure, thereby establishing cell polarity in epithelial cells [0.03%]
P120-catene对于N-钙黏著蛋白介导的正确连接结构的形成是必需的，因此在上皮细胞中建立了细胞极性
Chisa Ozaki,Masato Yoshioka,Sachiko Tominaga et al.
Chisa Ozaki et al.
The role of p120-catenin in the function of classical cadherins is still enigmatic despite various studies. To elucidate its role, we examined the effect of p120-catenin on the N-cadherin-mediated localization of junctional proteins in epit...
Satohiro Okuda,Tetsuya Higashiyama
Satohiro Okuda
Sexual reproduction in flowering plants requires pollen-tube guidance, which is thought to be mediated by chemoattractants derived from target ovules. To date, however, no convincing evidence has been reported of a particular molecule being...
Nobuaki Shiraki,Seiko Harada,Soichiro Ogaki et al.
Nobuaki Shiraki et al.
Although there are several markers available for the identification of endoderm derivatives such as the lung, pancreas, liver, and intestine, there are still very few surface markers available for the prospective isolation of the definitive...