Down-regulation of proliferation-inhibiting factor EGR1 in brain metastatic cancer cells on a soft matrix [0.03%]
软基质上脑转移性癌细胞中抑制增殖的因素EGR1的下调
Miki Omukai,Seiichiro Ishihara,Eishu Hirata et al.
Miki Omukai et al.
Metastasis of cancer cells to the brain leads to a poor prognosis in patients with cancer. The brain environment is characterized by cell types, extracellular matrices (ECMs), and mechanical properties that differ from those of the primary ...
Calcium and magnesium deficiency induces stress granule formation to maintain magnesium homeostasis [0.03%]
钙和镁缺乏通过诱导应激颗粒形成来维持细胞内镁稳态
Tomoko Sakihara,Masatsune Tsujioka,Shinya Honda et al.
Tomoko Sakihara et al.
Hypocalcemia and hypomagnesemia frequently occur under pathological conditions such as Crohn's disease or during diuretic treatment. However, how the combined deficiency of Ca2+ and Mg2+ affects cellular physiology has remained unclear. In ...
Force-dependent vinculin binding of α-catenin accelerates adherens junction formation [0.03%]
力依赖的α-连环蛋白-闭合蛋白结合加速粘着带组装
Quan Gan,Sachiko Tsukita,Shigenobu Yonemura
Quan Gan
Adherens junctions (AJs) mediate cell-cell adhesion and mechanical coupling in epithelial tissues. During AJ formation, punctate AJs (punctum adherens; PA) initially appear and subsequently transition into linear AJs or zonula adherens (ZAs...
Multiplex live imaging approaches to interrogate the interplay of multiple signaling pathways [0.03%]
多重活细胞成像技术解析多条信号通路的互作关系
Toru Hiratsuka,Danke Peng
Toru Hiratsuka
Multiplex live imaging enables simultaneous visualization of multiple signaling pathways in living cells, offering real-time insights into complex cellular networks. This methodology is essential in research fields such as cancer biology, w...
Expression of transcription factors KLF2 and KLF4 is induced by the mammalian Golgi stress response [0.03%]
转录因子KLF2和KLF4的表达由哺乳动物高尔基体压力反应诱导
Kanae Sasaki,Reishi Tanaka,Iona Miyake et al.
Kanae Sasaki et al.
The Golgi stress response is a homeostatic mechanism that augments Golgi function when Golgi function becomes insufficient (Golgi stress). Glycosylation of the core proteins of proteoglycans is one of the important functions of the Golgi. I...
Cholesterol in glioblastoma: impaired Hh signaling enhances epigenetic modifiers and decreases CAV1 [0.03%]
胆固醇在胶质母细胞瘤中的作用：Hh信号转导受损增强表观遗传修饰并降低CAV1表达
Tirthankar Baral,R Kirtana,Soumen Manna et al.
Tirthankar Baral et al.
Glioblastoma multiform (GBM) exhibit heterogeneity. Persistence of glioma stem cells (GSCs) are the root cause of tumor recurrence and drug resistance. So, targeting GSCs can be a better therapeutic strategy to tackle GBM. To mimic the tumo...
Emerging S100A11 roles: Regulation of focal adhesion dynamics and mechanosensing [0.03%]
新兴的S100A11功能：调控焦粘连动力学和机械感受能力
Tareg Omer Mohammed,Mahmoud I Shoulkamy,Djamel Eddine Chafai
Tareg Omer Mohammed
S100A11 is a small calcium-binding protein that has been studied in the context of growth regulation and membrane repair. However, it has recently been linked to the disassembly of focal adhesions. This new role of S100A11 has been linked t...
Depletion of Flot1 attenuates macropinosome-dependent mTORC1 activation in podocytes [0.03%]
Flot1耗竭通过抑制巨胞饮作用依赖的mTORC1活化减轻足细胞损伤
Yanan Li,Yuxin He,Longjiao Cheng et al.
Yanan Li et al.
Podocytes are terminally differentiated renal epithelial cells that play a crucial role in kidney filtration. Given this essential function, podocyte dysfunction results in kidney diseases known as podocytopathies. Previous studies have dem...
Enhanced release of ciliary extracellular vesicles suppresses cell migration and promotes cell aggregation [0.03%]
增强的纤毛细胞外囊泡释放可抑制细胞迁移并促进细胞聚集
Tetsuhiro Hara,Ryota Nakazato,Kenji Shirakawa et al.
Tetsuhiro Hara et al.
A primary cilium is a hair-like organelle that protrudes from the cell surface in many cell types. Growing evidence indicates that extracellular vesicles are released from primary cilia, and research is increasingly focused on defining the ...
Single-nucleosome imaging uncovers biphasic chromatin dynamics in inducible human transformed cells [0.03%]
单核小体成像揭示了人类转化细胞中诱导型染色质的两相动力学现象
Aoi Otsuka,Masa A Shimazoe,Shigeaki Watanabe et al.
Aoi Otsuka et al.
In higher eukaryotic cells, genomic DNA is packaged into dynamic chromatin domains whose physical behavior is coupled to DNA transactions such as transcription and DNA repair. Although chromatin organization is altered in cancer, how oncoge...