A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection [0.03%]
由磷脂肌醇3-激酶衍生的多肽抑制内吞作用和流感病毒感染
Yoichiro Fujioka,Aya O Satoh,Kosui Horiuchi et al.
Yoichiro Fujioka et al.
Endocytosis mediates the internalization and ingestion of a variety of endogenous or exogenous substances, including virus particles, under the control of intracellular signaling pathways. We have previously reported that the complex formed...
Two Decades of Genetically Encoded Biosensors Based on Förster Resonance Energy Transfer [0.03%]
基于福尔斯特共振能量转移的遗传编码生物传感器二十年的发展历程
Kenta Terai,Ayako Imanishi,Chunjie Li et al.
Kenta Terai et al.
Two decades have passed since the development of the first calcium indicator based on the green fluorescent protein (GFP) and the principle of Förster resonance energy transfer (FRET). During this period, researchers have advanced many nov...
Long Noncoding RNA LINC00202 Promotes Tumor Progression by Sponging miR-3619-5p in Retinoblastoma [0.03%]
长链非编码RNA LINC00202通过海绵作用吸附miR-3619-5p促进视网膜母细胞瘤的进展
Guigang Yan,Yi Su,Zhao Ma et al.
Guigang Yan et al.
Retinoblastoma (RB) is the most common intraocular malignancy in childhood, and the prognosis in the advanced RB is poor. It is urgent to find novel therapeutic targets. Long noncoding RNAs (lncRNAs) have critical functions in cancer progre...
PUM2 Promotes Glioblastoma Cell Proliferation and Migration via Repressing BTG1 Expression [0.03%]
PUM2通过抑制BTG1表达促进胶质母细胞瘤细胞增殖和迁移
Yuanyu Wang,Weili Sun,Jiankai Yang et al.
Yuanyu Wang et al.
PUM2, an RNA binding protein, is known to promote stem cell proliferation via repressing expressions of cell cycle genes. Similar with stem cells, malignant cells are characterized by unlimited proliferation and remote migration. However, r...
CCL20 Promotes Ovarian Cancer Chemotherapy Resistance by Regulating ABCB1 Expression [0.03%]
CCL20通过调节ABCB1表达促进卵巢癌的化疗耐药性
Shan Su,Xueqin Sun,Qinghua Zhang et al.
Shan Su et al.
Ovarian cancer (OC) is one of prevalent tumors and this study aimed to explore CCL20's effects on doxorubicin resistance of OC and related mechanisms. Doxorubicin-resistant SKOV3 DR cells were established from SKOV3 cells via 6-month contin...
MiR-187-3p Enhances Propranolol Sensitivity of Hemangioma Stem Cells [0.03%]
miR-187-3p可增强血管瘤干细胞对普萘洛尔的敏感性
Chao Liu,Zeliang Zhao,Zhidong Ji et al.
Chao Liu et al.
Infantile hemangioma is the most common soft tissue tumors in childhood. In clinic, propranolol is widely used for infantile hemangioma therapy. However, some of the infantile hemangioma patients display resistance to propranolol treatment....
PGSE Is a Novel Enhancer Regulating the Proteoglycan Pathway of the Mammalian Golgi Stress Response [0.03%]
PGSE是调节哺乳动物高尔基体压力反应的蛋白多糖通路的新增强子
Kanae Sasaki,Ryota Komori,Mai Taniguchi et al.
Kanae Sasaki et al.
The Golgi stress response is a homeostatic mechanism that augments the functional capacity of the Golgi apparatus when Golgi function becomes insufficient (Golgi stress). Three response pathways of the Golgi stress response have been identi...
Glycosphingolipid GM2 Induces Invasiveness in Irradiation-tolerant Lung Cancer Cells [0.03%]
甘油鞘脂GM2可诱导放射耐受性肺癌细胞的侵袭性
Seiichiro Ishihara,Kei Aoki,Takeomi Mizutani et al.
Seiichiro Ishihara et al.
Glycans, including glycosphingolipids, are broadly expressed in plasma membranes and play important roles in cell-cell interactions. Recently, it has been revealed that glycans participate in the regulation of malignant phenotypes of cancer...
An Anti-tumorigenic Role of the Warburg Effect at Emergence of Transformed Cells [0.03%]
瓦博格效应抑制转化细胞的肿瘤生成作用
Kojiro Ishibashi,Riku Egami,Kazuki Nakai et al.
Kojiro Ishibashi et al.
The Warburg effect is one of the hallmarks of cancer cells, characterized by enhanced aerobic glycolysis. Despite intense research efforts, its functional relevance or biological significance to facilitate tumor progression is still debatab...
Automatic Quantitative Segmentation of Myotubes Reveals Single-cell Dynamics of S6 Kinase Activation [0.03%]
基于单细胞的S6激酶激活动力学自动定量分割肌管的方法
Haruki Inoue,Katsuyuki Kunida,Naoki Matsuda et al.
Haruki Inoue et al.
Automatic cell segmentation is a powerful method for quantifying signaling dynamics at single-cell resolution in live cell fluorescence imaging. Segmentation methods for mononuclear and round shape cells have been developed extensively. How...