p18/Lamtor1-mTORC1 Signaling Controls Development of Mucin-producing Goblet Cells in the Intestine [0.03%]
P18/LAMTOR1-mTORC1信号控制肠道黏液分泌杯状细胞的发育
Shizuka Ito,Shigeyuki Nada,Daisuke Yamazaki et al.
Shizuka Ito et al.
Mechanistic target of rapamycin complex 1 (mTORC1) plays a pivotal role in controlling cell growth and metabolism in response to nutrients and growth factors. The activity of mTORC1 is dually regulated by amino acids and growth factor signa...
Internalization of AMPA-type Glutamate Receptor in the MIN6 Pancreatic β-cell Line [0.03%]
AMPA型谷氨酸受体在胰岛β细胞系MIN6中的内化作用
The Mon La,Hiroshi Yamada,Sayaka Seiriki et al.
The Mon La et al.
The activity of AMPA-type glutamate receptor is involved in insulin release from pancreatic β-cells. However, the mechanism and dynamics that underlie AMPA receptor-mediated insulin release in β-cells is largely unknown. Here, we show tha...
Biliverdin Reductase-A Deficiency Brighten and Sensitize Biliverdin-binding Chromoproteins [0.03%]
缺氧诱导因子1抑制剂biliverdin reductase-a缺乏可使结合biliverdin的发色蛋白质变性并提高其灵敏度
Kenju Kobachi,Sota Kuno,Shinya Sato et al.
Kenju Kobachi et al.
Tissue absorbance, light scattering, and autofluorescence are significantly lower in the near-infrared (NIR) range than in the visible range. Because of these advantages, NIR fluorescent proteins (FPs) are in high demand for in vivo imaging...
Visualization of Procollagen IV Reveals ER-to-Golgi Transport by ERGIC-independent Carriers [0.03%]
脯聚糖IV的可视化揭示了ERGIC非依赖性囊泡介导的内质网至高尔基体的转运过程
Yuto Matsui,Yukihiro Hirata,Ikuo Wada et al.
Yuto Matsui et al.
Collagen is the most abundant protein in animal tissues and is critical for their proper organization. Nascent procollagens in the endoplasmic reticulum (ER) are considered too large to be loaded into coat protein complex II (COPII) vesicle...
MON2 Guides Wntless Transport to the Golgi through Recycling Endosomes [0.03%]
MON2通过循环内体指导Wntless向高尔基体运输
Shen-Bao Zhao,Neta Dean,Xiao-Dong Gao et al.
Shen-Bao Zhao et al.
Endocytic cargos are transported to recycling endosomes (RE) but how these sorting platforms are generated is not well understood. Here we describe our biochemical and live imaging studies of the conserved MON2-DOPEY complex in RE formation...
Roles of the Translation Initiation Factor eIF2α Phosphorylation in Cell Structure and Function [0.03%]
翻译启动因子eIF2α磷酸化在细胞结构与功能中的作用机制研究
Sung Hoon Back
Sung Hoon Back
It is often assumed that α-subunit phosphorylation of the eukaryotic translation initiation factor 2 (eIF2) complex is just a mechanism to control protein synthesis. However, eIF2α phosphorylation induced by multiple kinases can recognize...
Centrosomal and Non-centrosomal Functions Emerged through Eliminating Centrosomes [0.03%]
通过去除中心体来实现中心体和非中心体功能的出现
Yutaka Takeda,Kanako Kuroki,Takumi Chinen et al.
Yutaka Takeda et al.
Centrosomes are highly conserved organelles that act as the major microtubule-organizing center (MTOC) in animal somatic cells. Through their MTOC activity, centrosomes play various roles throughout the cell cycle, such as supporting cell m...
Rab7B/42 Is Functionally Involved in Protein Degradation on Melanosomes in Keratinocytes [0.03%]
角蛋白细胞中 Rab7B/42 与黑素体上的蛋白质降解功能相关
Soujiro Marubashi,Mitsunori Fukuda
Soujiro Marubashi
Keratinocytes uptake melanosomes from melanocytes and retain them in the perinuclear region, where they form melanin caps. Although these processes are crucial to protecting nuclear DNA against ultraviolet injury, the molecular basis of mel...
Hierarchical Development of Motile Polarity in Durotactic Cells Just Crossing an Elasticity Boundary [0.03%]
刚度趋性细胞穿越弹性模量分界面时运动极性的层级发展过程
Thasaneeya Kuboki,Hiroyuki Ebata,Tomoki Matsuda et al.
Thasaneeya Kuboki et al.
Cellular durotaxis has been extensively studied in the field of mechanobiology. In principle, asymmetric mechanical field of a stiffness gradient generates motile polarity in a cell, which is a driving factor of durotaxis. However, the actu...
Development of a Rapid in vivo Assay to Evaluate the Efficacy of IRE1-specific Inhibitors of the Unfolded Protein Response Using Medaka Fish [0.03%]
斑马鱼体内快速测定 unfolded protein response 中IRE1特异性抑制剂有效性的方法开发
Byungseok Jin,Tokiro Ishikawa,Mai Taniguchi et al.
Byungseok Jin et al.
Three types of transmembrane protein, IRE1α/IRE1β, PERK, and ATF6α/ATF6β, are expressed ubiquitously in vertebrates as transducers of the unfolded protein response (UPR), which maintains the homeostasis of the endoplasmic reticulum. IRE...