CCL5 enhances invasion of squamous cell carcinoma via syndecan-1-dependent ERK signaling [0.03%]
CCL5通过依赖于syndecan-1的ERK信号增强鳞状细胞癌的侵袭性
Toko Yamazaki,Yuji Kumagai,Kosuke Maeda et al.
Toko Yamazaki et al.
Cancer cells form clusters and invade the surrounding stroma. This phenomenon is associated with metastasis and poor prognosis in patients with cancer. Therefore, prevention of invasion may improve cancer therapy. A previous study suggested...
Metformin attenuates cuprizone-induced mitochondrial dysfunction and senescence-associated changes in primary neuronal cells [0.03%]
二甲双胍通过减轻铜腙诱导的原代神经元细胞线粒体功能障碍和衰老相关变化发挥保护作用
Yeojin Kim,Hyunbum Jeon,Sunyoung Kwon et al.
Yeojin Kim et al.
Mitochondrial dysfunction and cellular senescence are key features of brain aging and neurodegenerative diseases. Cuprizone (CPZ), a mitochondrial toxin, induces oxidative stress, abnormal lipid metabolism, and iron accumulation in neurons ...
Loss of macroautophagy results in abnormality of the endoplasmic reticulum in insulin-secreting MIN6 cells [0.03%]
自噬丧失导致胰岛素分泌MIN6细胞内质网异常
Asako Kishimoto,Shunsuke Saito,Byungseok Jin et al.
Asako Kishimoto et al.
Macroautophagy is a highly conserved system that degrades various materials inside the cell ranging from proteins to organelles. Atg5 is a protein essential for the formation of autophagosomes, which sequester materials by double membrane a...
Changes in nuclear morphology and size in mammalian temperature-sensitive mutants [0.03%]
哺乳动物温度敏感突变型细胞核形态和大小的改变
Kimihiko Sugaya
Kimihiko Sugaya
Nuclear morphology alters during development and disease. Nuclear size and shape are regulated through several mechanisms. In this study, details of phenotypes of temperature-sensitive mutants, which were isolated from Chinese hamster CHO-K...
Shumpei Nakashima,Mitsunori Fukuda
Shumpei Nakashima
Tubular-shaped recycling endosomes, known as tubular endosomes, are present in certain types of cells, including HeLa cells, and they regulate the recycling of clathrin-independent endocytosed (CIE) cargo proteins to the plasma membrane. Se...
Yuying Hong,Li Yu,Ikuko Takahashi et al.
Yuying Hong et al.
Tumor endothelial cells (TECs) play a key role in tumor growth and metastasis. They exhibit distinct phenotypic and functional features compared with normal endothelial cells (NECs). Although microRNAs (miRNAs) play diverse roles in tumor p...
A mei-P26 is required for initiation of meiosis in the Drosophila male germline [0.03%]
Drosophila雄性生殖系中启动减数分裂需mei-P26蛋白质
Mai Oda,Yuri Tanaka,Yoshihiro H Inoue
Mai Oda
Mei-P26, a member of the TRIM-NHL family, plays a pivotal role in Drosophila germline development, including female meiosis. However, its role in male meiosis remains unclear. We observed abnormal spermatid cysts comprising 16 cells in mei-...
Down-regulation of proliferation-inhibiting factor EGR1 in brain metastatic cancer cells on a soft matrix [0.03%]
软基质上脑转移性癌细胞中抑制增殖的因素EGR1的下调
Miki Omukai,Seiichiro Ishihara,Eishu Hirata et al.
Miki Omukai et al.
Metastasis of cancer cells to the brain leads to a poor prognosis in patients with cancer. The brain environment is characterized by cell types, extracellular matrices (ECMs), and mechanical properties that differ from those of the primary ...
Calcium and magnesium deficiency induces stress granule formation to maintain magnesium homeostasis [0.03%]
钙和镁缺乏通过诱导应激颗粒形成来维持细胞内镁稳态
Tomoko Sakihara,Masatsune Tsujioka,Shinya Honda et al.
Tomoko Sakihara et al.
Hypocalcemia and hypomagnesemia frequently occur under pathological conditions such as Crohn's disease or during diuretic treatment. However, how the combined deficiency of Ca2+ and Mg2+ affects cellular physiology has remained unclear. In ...
Force-dependent vinculin binding of α-catenin accelerates adherens junction formation [0.03%]
力依赖的α-连环蛋白-闭合蛋白结合加速粘着带组装
Quan Gan,Sachiko Tsukita,Shigenobu Yonemura
Quan Gan
Adherens junctions (AJs) mediate cell-cell adhesion and mechanical coupling in epithelial tissues. During AJ formation, punctate AJs (punctum adherens; PA) initially appear and subsequently transition into linear AJs or zonula adherens (ZAs...