[The characteristic of oral status and dental treatment of leprosy sequelae patients] [0.03%]
继发性麻痹患者口腔健康状况及就诊需求的调查研究
Masatsugu Nakagawa,Akemi Shimizu
Masatsugu Nakagawa
The leprosy sequelae especially the handicap of eyes and hands makes difficult to maintain the oral health status. So, leprosy sequelae patients are controlling themselves by creative and original methods. However even such efforts have har...
[Review of WHO Expert Committee on Leprosy 8th report, --comparison to 7th report] [0.03%]
[世卫组织第8次麻风病专家委员会报告评述--与第7次报告比较]
Shinichi Kitajima,Junichiro En,Shiori Kitajima et al.
Shinichi Kitajima et al.
In 2012 the WHO Expert Committee on Leprosy published its 8th report, 14 years after the publication of its 7th report in 1998. This report, the first since the leprosy reduction goal was met in 2000, highlights key points such as improveme...
[Rapid detection of mutations related to Mycobacterium leprae drug resistance by using Hp-rPCR (hairpin primer- real time PCR) method] [0.03%]
[利用发夹引物的实时定量PCR方法快速检测麻风分枝杆菌耐药相关突变]
Masanori Kai
Masanori Kai
Rapid and simple detection method of drug resistance bacteria is required. In the present study, Hp-rPCR (hairpin primer-real time PCR) was applied to Mycobacterium leprae genes to detect mutations. Target sites of the method were as follow...
Masamichi Goto,Reiko Nogam,Yoshiko Okano et al.
Masamichi Goto et al.
ad hoc committee of Japanese Leprosy Association recommends revised standard treatment protocol of leprosy in Japan, which is a modification of World Health Organization's multidrug therapy (WHO/MDT, 2010). For paucibacillary (PB) leprosy, ...
Innate and acquired immune responses to mycobacterial infections: involvement of IL-17A/IL-23 axis in protective immunity [0.03%]
针对结核杆菌感染的固有及获得性免疫反应：IL-17A/IL-23轴在保护性免疫中的作用
Masayuki Umemura,Goro Matsuzaki
Masayuki Umemura
Pulmonary tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, and continues to be a serious threat to human life. Since M. tuberculosis establishes intracellular parasitism in macrophages, host innate and acquired im...
Sohkichi Matsumoto
Sohkichi Matsumoto
Instead of rapid multiplication, pathogenic mycobacteria, such as Mycobacterium tuberculosis are likely to have acquired slow but long life. Host immunity affords desirable non-competitive environment for M tuberculosis in human lungs, wher...
[Towards novel tuberculosis and leprosy vaccine development: the role of Th1-inducing peptide in cytotoxic T cell differentiation] [0.03%]
新型结核病和麻风疫苗研发中的Th1诱导肽CTL分化作用的研究
Toshiki Tamura,Yoko Shimohakamada,Masahiko Makino
Toshiki Tamura
The effectiveness of a vaccine against tuberculosis and leprosy is mainly judged by its capability to induce memory CD8 cytotoxic T cells (CTL). It has been reported that 'help' from CD4+ T cells is required to induce memory CTL. However, h...
Masahiko Makino
Masahiko Makino
A novel recombinant BCG (BCG-DHTM), that was deficient in urease, expressed with gene encoding the fusion of BCG-derived HSP70 and M. tuberculosis-derived major membrane protein (MMP)-II, was constructed for use as a vaccine against tubercu...
[International cooperation with the neglected tropical disease Buruli ulcer in Togo] [0.03%]
[与多哥坏死性皮肤结核的合作]
Tomoki Niiyama
Tomoki Niiyama
The objectives of this paper are to grasp the current status of an endemic disease, known as Buruli ulcer (BU), in the Republic of Togo and the expansion of international assistance in the field. By adopting the explicit support model, this...