Analysis of benzo[a]pyrene metabolites formed by rat hepatic microsomes using high pressure liquid chromatography: optimization of the method [0.03%]
高效液相色谱法分析苯并(a)芘在大鼠肝微粒体中代谢产物的研究及方法优化
Michaela Moserová,Věra Kotrbová,Dagmar Aimová et al.
Michaela Moserová et al.
A simple and sensitive method was developed to separate the carcinogenic polycyclic aromatic hydrocarbon (PAH), benzo[a]pyrene (BaP), and six of its oxidation metabolites generated by rat hepatic microsomes enriched with cytochrome P450 (CY...
Ladislav Soltés,Grigorij Kogan
Ladislav Soltés
One of the very complex structures in the vertebrates is the joint. The main component of the joint is the synovial fluid with its high-molar-mass glycosaminoglycan hyaluronan, which turnover is approximately twelve hours. Since the synovia...
Molecular, genetic and epigenetic pathways of peroxynitrite-induced cellular toxicity [0.03%]
过氧亚硝酸盐诱导的细胞毒性分子、遗传和表观遗传途径
Ahmet Korkmaz,Sukru Oter,Melik Seyrek et al.
Ahmet Korkmaz et al.
Oxidative stress plays a key role in the pathogenesis of cancer and many metabolic diseases; therefore, an effective antioxidant therapy would be of great importance in these circumstances. Nevertheless, convincing randomized clinical trial...
Isoflavonoids - an overview of their biological activities and potential health benefits [0.03%]
异黄酮-生物活性及潜在健康效益概述
Eva Miadoková
Eva Miadoková
There are many biological activities attributed to isoflavonoids. The majority of them could be beneficial and some of them may be detrimental, depending on specific circumstances. Isoflavonoids play an important role in human nutrition as ...
Histone deacetylase inhibitors valproate and trichostatin A are toxic to neuroblastoma cells and modulate cytochrome P450 1A1, 1B1 and 3A4 expression in these cells [0.03%]
谷氨酸和十一烷三醇A对神经母细胞瘤细胞有毒性作用并调节这些细胞的细胞色素P450 1A1、1B1及3A4表达
Jana Hřebačková,Jitka Poljaková,Tomáš Eckschlager et al.
Jana Hřebačková et al.
Histone deacetylase inhibitors such as valproic acid (VPA) and trichostatin A (TSA) were shown to exert antitumor activity. Here, the toxicity of both drugs to human neuroblastoma cell lines was investigated using MTT test, and IC50 values ...
The effects of selected flavonoids on cytochromes P450 in rat liver and small intestine [0.03%]
几种黄酮类化合物对大鼠肝脏和小肠细胞色素P450的影响研究
Jitka Křížková,Kamila Burdová,Marie Stiborová et al.
Jitka Křížková et al.
In recent years, the consumption and use of dietary supplements containing concentrated phytochemicals (e.g. flavonoids) increased dramatically. Flavonoids, as foreign compounds (xenobiotics), have great potential to modulate the activity o...
Oxidation of the carcinogenic non-aminoazo dye 1-phenylazo-2-hydroxy-naphthalene (Sudan I) by cytochromes P450 and peroxidases: a comparative study [0.03%]
血红素P450和过氧化物酶对致癌非氨基偶氮染料1-(苯基偶氮)-2-羟基萘(苏丹I)的氧化：一项比较研究
Marie Stiborová,Václav Martínek,Marcela Semanská et al.
Marie Stiborová et al.
Sudan I [1-(phenylazo)-2-hydroxynaphthalene, C.I. Solvent Yellow 14, CAS No: 842-07-9] is used as the compound employed in chemical industry and to color materials such as hydrocarbon solvents, oils, fats, waxes, plastics, printing inks, sh...
Comparison of chromosomal aberrations frequency and polymorphism of GSTs genes in workers occupationally exposed to cytostatics or anaesthetics [0.03%]
职业接触细胞毒药物或麻醉药的工人染色体畸变率和GST基因多态性的比较研究
Ludovít Mušák,Erika Halašová,Tatiana Matáková et al.
Ludovít Mušák et al.
Authors compared the incidence of chromosomal aberrations (CAs) of workers occupationally exposed to cytostatics (group EXP1) or anaesthetics (group EXP2) in relationship to polymorphism of GSTM1, GSTP1 and GSTT1 genes. The cytogenetic anal...
Rastislav Sabo,Lucia Sabová,Jaroslav Legáth
Rastislav Sabo
Organisms used in risk assessment of pesticides must be the most sensitive ones to pesticides exposure. The aim of this study was to observe the effect of two commercial pesticide products (containing glyphosate and tolylfluanid) to larval ...
Miloň Tichý,Marián Rucki
Miloň Tichý
OECD principles of validation of Quantitative Structure - Activity Relationships (QSAR) models for legislative purposes are given and explained. Reasons of their origination and development, like system REACH, are described. A basic impulse...