Body distribution of C-methionine and FDG in rat measured by microPET [0.03%]
微PET测定大鼠体内蛋氨酸和氟脱氧葡萄糖的分布研究
Svorad Stolc,Lucia Jakubíková,Ivica Kukurová
Svorad Stolc
Compounds (18)F-fluorodeoxyglucose ((18)FDG) and (11)C-methionine ((11)C-MET) are radiodiagnostics frequently used in clinical Positron Emission Tomography (PET) as well in preclinical studies of various pathologies. The present study was f...
Safety assessment of the pyridoindole derivative SMe1EC2: developmental neurotoxicity study in rats [0.03%]
吡啶并吲哚衍生物SMe1EC2的安全性评价：大鼠发育神经毒性试验
Eduard Ujházy,Mojmír Mach,Jana Navarová et al.
Eduard Ujházy et al.
The present study deals with effect of prenatal and neonatal administration of the synthetic pyridoindole derivative SMe1EC2 (2-ethoxycarbonyl-8-methoxy-2,3,4,4a,5,9b-hexahydro-1H-pyrido-[4,3b] indolinium chloride) on postnatal and neurobeh...
Trends in vascular pharmacology research in the Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Comenius University, Bratislava [0.03%]
考门纽斯大学医学部药理学和临床药理学系血管药理研究进展
Viera Kristová,Milan Kriška,Róbert Vojtko et al.
Viera Kristová et al.
Research in the Department of Pharmacology started to focus intensively on fetal circulation in the 60s. Results of experiments contributed to clarification of the conversion of fetal circulation type to the adult type: the mechanism of the...
Utilization of adjuvant arthritis model for evaluation of new approaches in rheumatoid arthritis therapy focused on regulation of immune processes and oxidative stress [0.03%]
利用佐剂性关节炎模型评估新的类风湿性关节炎治疗方法着重于调节免疫过程和氧化应激
Katarína Bauerová,Silvester Poništ,Danica Mihalová et al.
Katarína Bauerová et al.
As a number of disease-modifying anti-rheumatic drugs often have side effects at high doses and/or during long-term administration, increased efficacy without increased toxicity is expected for combination therapy of rheumatoid arthritis (R...
Soňa Fraňová,Anna Strapková,Juraj Mokrý et al.
Soňa Fraňová et al.
Allergic asthma is the most frequent disease of the respiratory tract. The aim of the current experimental and clinical studies was to find new sources of drugs able to control asthmatic inflammation and airway hyperresponsiveness. Our expe...
Ružena Sotníková,Jana Nedelčevová,Jana Navarová et al.
Ružena Sotníková et al.
One of the factors proposed as mediators of vascular dysfunction observed in diabetes is the increased generation of reactive oxygen species (ROS). This provides support for the use of antioxidants as early and appropriate pharmacological i...
Antonin Lojek,Milan Cíž,Michaela Pekarová et al.
Antonin Lojek et al.
The purpose of the study was to investigate the effects of H(1)-antihistamines of the 1(st) generation (antazoline, bromadryl, brompheniramine, dithiaden, cyclizine, chlorcyclizine, chlorpheniramine, clemastine) and the 2(nd) generation (ac...
Pharmacological regulation of neutrophil activity and apoptosis: Contribution to new strategy for modulation of inflammatory processes [0.03%]
药理调节中性粒细胞的活性和凋亡：对炎症过程的新调控策略的贡献
Viera Jančinová,Tomáš Perečko,Radomír Nosáĺ et al.
Viera Jančinová et al.
Novel strategies of antiinflammatory therapy are based upon pharmacological agents capable to enhance the resolution - i.e. the termination of the beneficial inflammation before it may turn into an adverse chronic stage. In contrast to the ...
Immunobiological properties of selected natural and chemically modified phenylpropanoids [0.03%]
某些天然茋类化合物及其衍生物的免疫生物学特性研究
Juraj Harmatha,Zdeněk Zídek,Eva Kmoníčková et al.
Juraj Harmatha et al.
Effects of natural and structurally transformed lignans compared with stilbenes or stilbenoids on production of nitric oxide (NO) triggered by lipopolysaccharide (LPS) and interferon-γ (IFN-γ), tested under in vitro conditions using murin...
Michal Dubovický
Michal Dubovický