Effect of N'-nitrosodimethylamine on red blood cell rheology and proteomic profiles of brain in male albino rats [0.03%]
N-亚硝基二甲胺对雄性 Wistar 大鼠红细胞流变特性和脑蛋白表达的影响
Areeba Ahmad,Ravish Fatima,Veena Maheshwari et al.
Areeba Ahmad et al.
We investigated the effects of N'-nitrosodimethylamine (NDMA) induced toxicity on red blood cell rheology in male rats and identified bands in proteomic profiles of brain which can be used as novel markers. Polyacrylamide gel electrophoresi...
Flavonoids in prevention of diseases with respect to modulation of Ca-pump function [0.03%]
黄酮类化合物通过调节钙泵功能在疾病预防中的作用
Lubica Horáková
Lubica Horáková
Flavonoids, natural phenolic compounds, are known as agents with strong antioxidant properties. In many diseases associated with oxidative/nitrosative stress and aging they provide multiple biological health benefits. Ca(2+)-ATPases belong ...
Helena Kandárová,Silvia Letašiová
Helena Kandárová
The development of alternative methods to animal experimentation has progressed rapidly over the last 20 years. Today, in vitro and in silico methods have an important role in the hazard identification and assessment of toxicology profile o...
Marie Stiborová,Jitka Poljaková,Eva Martínková et al.
Marie Stiborová et al.
Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action. This anticancer agent should be considered a pro-drug, whose pharmacological efficiency and/or genotoxic side effects are dependent on its cytochrome P45...
Cardioprotective activity of flax lignan concentrate extracted from seeds of Linum usitatissimum in isoprenalin induced myocardial necrosis in rats [0.03%]
来源于亚麻木子的亚麻木质素浓缩物对异丙肾上腺素致大鼠心肌坏死的保护作用
Anand A Zanwar,Mahabaleshwar V Hegde,Subhash L Bodhankar
Anand A Zanwar
The objective of the study was to evaluate the cardioprotective activity of flax lignan concentrate (FLC) in isoprenalin (ISO) induced cardiotoxicity in rats. Male Wistar rats (200-230 g) were divided into three groups. Group I: control, Gr...
Ivana Haluzová,Helena Modrá,Jana Blahová et al.
Ivana Haluzová et al.
Markers of xenobiotic metabolization (cytochrome P450, ethoxyresorufin-O-deethylase, glutathione and glutathione-S-transferase) were investigated in the liver of the common carp Cyprinus carpio after 28-day exposure to different pesticide f...
In vitro inhibition of porcine cytochrome P450 by 17β -estradiol and 17α-estradiol [0.03%]
17-β雌二醇和17-α雌二醇对猪细胞色素P450酶的抑制作用
Galia Zamaratskaia,Martin Krøyer Rasmussen,Isabelle Herbin et al.
Galia Zamaratskaia et al.
Sexually mature pigs are known to possess high concentrations of testicular steroids, which have been shown to change the activities of cytochrome P450 in vitro. The aim of the present study was to evaluate the regulation of CYP1A and CYP2E...
Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract [0.03%]
天然黄酮类化合物作为防治糖尿病白内障的多功能潜在药物
Milan Stefek
Milan Stefek
Cataract is one of the earliest secondary complications of diabetes mellitus. The lens is a closed system with limited capability to repair or regenerate itself. Current evidence supports the view that cataractogenesis is a multifactorial p...
Biochemical aspects of nitric oxide synthase feedback regulation by nitric oxide [0.03%]
一氧化氮的生化方面自反馈调节的一氧化氮合酶
Jana Kopincová,Angelika Púzserová,Iveta Bernátová
Jana Kopincová
Nitric oxide (NO) is a small gas molecule derived from at least three isoforms of the enzyme termed nitric oxide synthase (NOS). More than 15 years ago, the question of feedback regulation of NOS activity and expression by its own product w...
The new pyridoindole antioxidant SMe1EC2 and its intervention in hypoxia/hypoglycemia-induced impairment of longterm potentiation in rat hippocampus [0.03%]
新型吡啶并吲哚抗氧化剂SMe1EC2及其对大鼠海马低氧/低糖诱导的长期增强损伤的干预作用
Zdenka Gáspárová,Vladimír Snirc,Svorad Stolc
Zdenka Gáspárová
Previously, the pyridoindole SMe1EC2 was proved to inhibit lipoperoxidation and carbonylation of proteins in rat brain cortex in the system Fe(2+)/ascorbate and improvement of resistance of the rat hippocampus was reported against ischemic ...