Nikola Bradarić
Nikola Bradarić
About 25% of all liver transplantations in USA are performed for liver disease due to viral hepatitis, 25% of them related to hepatitis B. It is also known that 90%-100% of transplanted persons with proven replicative stage of hepatitis B [...
Miro Morović
Miro Morović
More that 350 million people worldwide suffer from chronic hepatitis B virus (HBV) infection. Up to 40 percent of persons infected with the virus may develop complications related to cirrhosis or hepatocellular carcinoma. This reservoire is...
Davor Stimac,Sandra Milić
Davor Stimac
The goals of treatment for hepatitis C are eradication of viral infection and prevention of progression to end-stage liver disease. To decide on whom to treat, it is necessary to consider the following parameters: stage of disease, comorbid...
Ivica Pavić
Ivica Pavić
Patients with moderate to severe chronic hepatitis and active HBV replication should be managed according to HBeAg status and presence of coinfecting virus(es) (HDV, HCV, HIV). Treatment is also recommended for immunocompromised patients an...
Vesna Colić-Cvrlje
Vesna Colić-Cvrlje
Hepatitis C is a major public health problem. General screening is not advisable and should be limited to risk groups. The gold standard for the assessment of disease severity is liver biopsy. AST and ALT do not correlate with histology. Se...
Vitomir Burek
Vitomir Burek
Accurate diagnosis of viral hepatitis is based on determination of specific viral markers. In HBV infection they include HBsAg, anti-HBs, HBeAg, anti-HBe, anti-HBc, IgM anti-HBc, and HBV DNA. There are patients with HBV marker constellation...
Boris Vucelić,Irena Hrstić
Boris Vucelić
Viral factors are important in the pathogenesis of liver disease either directly, through cell injury associated with the accumulation of intact virus or viral proteins, or indirectly, through the host immune response. The immune response o...
Stjepan Mise
Stjepan Mise
Hepatitis B and C are diseases characterized by a high global prevalence, complex clinical course and limited efficacy of currently available antiviral therapy. Hepatitis B: local factors have a significant influence not only on the disease...
Adriana Vince
Adriana Vince
Significant progress in the understanding of the natural history of hepatitis B and C has been made in recent years due to molecular diagnosis techniques. The most important biologic feature of hepatitis B and C viruses (HBV, HCV) is their ...
Vladimira Lesnikar
Vladimira Lesnikar
Preventive measures are determined by epidemiological characteristics of HBV and HCV infections. A significant difference between these two infections is in the availability of effective vaccine for hepatitis B. Vaccine against hepatitis C ...