Laurent Hocqueloux,Jean-Paul Viard
Laurent Hocqueloux
Archiving HIV in its long half-life target cells is responsible for building what are called its reservoirs. The quantification of total HIV DNA in blood mononuclear cells, which probably represents only an approximation of all anatomical a...
Nicolas Huot,Philippe Rascle,Michaela Müller-Trutwin
Nicolas Huot
Even today, despite triple therapy, the epidemic of the human immunodeficiency virus (HIV) is a major public health problem. In this perspective, continuous research is essential for the development of curative and vaccinal approaches. Anim...
Pauline Trémeaux,Christine Rouzioux,Véronique Avettand-Fènoël
Pauline Trémeaux
Current antiretroviral therapy allows the control of HIV replication but a relapse occurs most of the time in case of treatment interruption. The viral genome integration explains this persistence of HIV in all body tissues, at very variabl...
[Viral latency of HIV-1] [0.03%]
[HIV-1的潜伏感染]
Sophie Bouchat,Carine Van Lint
Sophie Bouchat
Human immunodeficiency virus (HIV-1) latency is clinically highlighting via the persistence of a residual viral load in cART-treated patients due to the reactivation of cellular reservoirs. Two forms of latency coexist but the contribution ...
Véronique Avettand-Fènoël
Véronique Avettand-Fènoël
Zina M Uckeley,Jana Koch,Nicole D Tischler et al.
Zina M Uckeley et al.
Phleboviruses constitute a large group of arthropod-borne viruses (arboviruses), mainly transmitted to their hosts by sandflies and ticks, occasionally by mosquitoes. These viruses have a worldwide distribution and many cause serious diseas...
[Architecture and biogenesis of positive-stranded RNA virus replication organelles] [0.03%]
正链RNA病毒复制器官的架构和发生生物学
William Bakhache,Élodie Couderc,Aymeric Neyret et al.
William Bakhache et al.
The replication of viral pathogens relies on their ability to manipulate their host. Several steps of the infectious cycle require the hijacking of cellular membranes. Positive stranded RNA viruses replicating in the cytoplasm of their host...
Robert J Scarborough,Ryan P Goguen,Anne Gatignol
Robert J Scarborough
Vincent Turon-Lagot,Antonio Saviano,Catherine Schuster et al.
Vincent Turon-Lagot et al.
An estimated 70 million people are chronically infected with hepatitis D (delta) virus (HDV) worldwide. HDV is a small satellite virus of hepatitis B virus (HBV) requiring HBV for the completion of its cycle. Hepatitis D is the most severe ...
Robert J Scarborough,Ryan P Goguen,Anne Gatignol
Robert J Scarborough