Artificial Intelligence in Drug Discovery: A Comprehensive Review of Data-driven and Machine Learning Approaches [0.03%]
药物发现中的人工智能：数据驱动和机器学习方法的全面回顾
Hyunho Kim,Eunyoung Kim,Ingoo Lee et al.
Hyunho Kim et al.
As expenditure on drug development increases exponentially, the overall drug discovery process requires a sustainable revolution. Since artificial intelligence (AI) is leading the fourth industrial revolution, AI can be considered as a viab...
Jeesoo Kim,Thi Thanh Hanh Nguyen,Juhui Jin et al.
Jeesoo Kim et al.
Streptococcus mutans plays an important role in the development of dental caries in humans by synthesizing adhesive insoluble glucans from sucrose by mutansucrase activity. To explore the anti-cariogenic characteristics of rubusoside (Ru), ...
Improvement in the Reproducibility of a Paper-based Analytical Device (PAD) Using Stable Covalent Binding between Proteins and Cellulose Paper [0.03%]
利用蛋白质和纸张之间稳定的共价结合提高纸基分析设备（PAD）的重现性
Woogyeong Hong,Seong-Geun Jeong,Gyurak Shim et al.
Woogyeong Hong et al.
Paper-based analytical devices (PADs) have been widely used in many fields because they are affordable and portable. For reproducible quantitative analysis, it is crucial to strongly immobilize proteins on PADs. Conventional techniques for ...
A rapidly new-typed detection of norovirus based on F0F1-ATPase molecular motor biosensor [0.03%]
一种基于F0F1-ATP酶分子马达的诺如病毒新型快速检测方法
Zhuo Zhao,Jie Zhang,Mei-Ling Xu et al.
Zhuo Zhao et al.
In order to adapt port rapid detection of food borne norovirus, presently we developed a new typed detection method based on F0F1-ATPase molecular motor biosensor. A specific probe was encompassed the conservative region of norovirus and F0...
Kanagavel Deepankumar,Saravanan Prabhu Nadarajan,Dong-Ho Bae et al.
Kanagavel Deepankumar et al.
Genetically encoded fluorescent proteins are extensively utilized for labeling and imaging proteins, organelles, cell tissues, and whole organisms. In this study, we explored the feasibility of mRFP1 and its variants for measuring intracell...
Inhibition effect of flavonoid compounds against neuraminidase expressed in Pichia pastoris [0.03%]
表达于毕赤酵母中的神经氨酸酶的抑酶活性及动力学研究(flavonoids化合物篇)
Thi Thanh Hanh Nguyen,Hee-Kyoung Kang,Young-Min Kim et al.
Thi Thanh Hanh Nguyen et al.
Neuraminidase (NA) is one of the two glycoproteins on the surface of influenza virus, which cleaves terminal sialic acid residues and facilitates the release of virions from infected cells. The recombinant NA from H5N1 influenza virus strai...
Recent development of highly sensitive protease assay methods: Signal amplification through enzyme cascades [0.03%]
高灵敏蛋白酶测定方法的最新进展：通过酶联反应放大信号
Hyun Kyung Yoon,Sang Taek Jung,Jae-Ho Kim et al.
Hyun Kyung Yoon et al.
Proteases are involved in almost all biological processes, and therefore, aberrant activity of many of these enzymes is an important indicator of disease. Various methods have been developed to analyze protease activity, among which, protea...
Inhibitory effects of epigallocatechin gallate and its glucoside on the human intestinal maltase inhibition [0.03%]
儿茶素和它的糖苷抑制人肠麦芽糖酶的活性作用研究
Thi Thanh Hanh Nguyen,Sun-Hwa Jung,Sun Lee et al.
Thi Thanh Hanh Nguyen et al.
Human intestinal maltase (HMA) is an α-glucosidase responsible for the hydrolysis of α-1,4-linkages from the non-reducing end of malto-oligosaccharides. HMA has become an important target in the treatment of type-2 diabetes. In this study...
Production of a heat-labile enterotoxin B subunit-porcine epidemic diarrhea virus-neutralizing epitope fusion protein in transgenic lettuce (Lactuca sativa) [0.03%]
利用转基因生菜表达热不稳定肠毒素B亚单位-猪流行性腹泻病毒中和表位融合蛋白
Nguyen-Xuan Huy,Young-Sook Kim,Sang-Chel Jun et al.
Nguyen-Xuan Huy et al.
Plant-based vaccines have been produced in transgenic plants including tobacco, potatoes, corn, and rice. However, these plants are not suitable for administration without cooking. To overcome this obstacle, a fusion gene encoding the synth...
Simultaneous extraction and separation of liquiritin, glycyrrhizic acid, and glabridin from licorice root with analytical and preparative chromatography [0.03%]
分析与制备色谱法同时提取和分离甘草根中的甘草素、甘草酸和光果甘草定
Minglei Tian,Hongyuan Yan,Kyung Ho Row
Minglei Tian
Simultaneous extraction and separation of liquiritin, glycyrrhizic acid, and glabridin from licorice were developed by liquidliquid extraction with liquid chromatography separation. By utilizing different extraction solvents, procedures, an...