Targeted gene expression profiling as a tool for diagnostic cell-of-origin determination and prognostic stratification in diffuse large B-cell lymphoma [0.03%]
弥漫性大B细胞淋巴瘤中靶向基因表达谱分析在诊断起源细胞决定和预后分层中的应用
Veronika Navrkalová,Andrea Marečková,Lenka Radová et al.
Veronika Navrkalová et al.
Classification of diffuse large B-cell lymphoma (DLBCL) according to cell-of-origin (COO) distinguishes two main biological subtypes: activated B-cell-like (ABC) and germinal center B-cell-like (GCB). Although this distinction reflects diff...
The advantages and limitations of the new FIGO 2023 staging system for endometrial carcinoma from the perspective of the clinician and pathologist [0.03%]
从临床医生和病理学家的视角看FIGO 2023子宫内膜癌分期系统的优缺点
Martin Hruda,Radoslav Matěj,Borek Sehnal et al.
Martin Hruda et al.
The Czech Republic is one of the countries with the highest incidence of endometrial cancer in the world. In June 2023, the Women's Cancer Committee of the International Federation of Gynaecology and Obstetrics (FIGO) introduced a new stagi...
Review
Ceskoslovenska patologie. 2026;62(1):35-42. DOI: 2026
Kateřina Kamarádová,Václav Stejskal,Dominika Écsiová
Kateřina Kamarádová
Castleman disease (CD) is a mesmerising group of disorders mainly affecting lymph nodes sharing some morphological features but with heterogeneous aetiology, clinical presentation and therapeutic approaches. Morphologically, hyaline-vascula...
Review
Ceskoslovenska patologie. 2026;62(1):17-34. DOI: 2026
Testing Claudin 18.2 Expression in Gastric and Gastroesophageal Junction Adenocarcinoma: Current Status and Near‑Future Outlook [0.03%]
胃及胃食管交界处腺癌中Claudin 18.2表达检测：现状与未来展望
Pavel Dundr,Radoslav Matěj
Pavel Dundr
Claudin 18.2 (CLDN18.2) represents one of the newest biomarkers expected to enter routine testing in the near future and expanding the spectrum of available predictive markers. It is currently a clinically relevant predictor for adenocarcin...
Review
Ceskoslovenska patologie. 2026;62(1):13-16. DOI: 2026
Current methods in multiplex immunohistochemistry for formalin-fixed tissue samples [0.03%]
甲醛固定组织样本的多重免疫组化现行方法
Romana Hendrychová,Kateřina Čížková,Dominik Hraboš et al.
Romana Hendrychová et al.
Traditional histopathological methods, such as hematoxylin and eosin staining and chromogenic immunohistochemistry, are still primarily used in clinical practice, however, they are limited in their ability to simultaneously detect multiple ...
An unusual case of late recurrent adult granulosa cell tumor and mature teratoma arising within the same ovary, confirmed by NGS analysis [0.03%]
NGS确认的罕见同一侧卵巢复发性成人颗粒细胞瘤和成熟畸胎瘤病例
Adam Šafanda,Nikola Hájková,Jan Galko et al.
Adam Šafanda et al.
Adult granulosa cell tumor is a predominant malignant tumor among ovarian sex cord-stromal tumors, representing approximately 3-5% of all ovarian malignancies and being known for its risk of recurrence with high mortality rate. We present a...
Case Reports
Ceskoslovenska patologie. 2025;61(4):206-209. DOI: 2025
Unusual histopathologic finding in axillary lymph node in patient with invasive breast carcinoma NST: Case report and literature review [0.03%]
侵袭性乳腺非特殊型癌患者的腋窝淋巴结罕见病理发现：病例报告和文献复习
Dominika Fritzová,Dominik Hraboš,Martina Navrátilová et al.
Dominika Fritzová et al.
Lymph nodes are routinely examined during the staging of malignant tumors, particularly those of epithelial origin. The assessment of metastatic involvement, especially of sentinel or regional lymph nodes, is absolutely crucial for the appr...
Magdalena Hudcová,Bohuslav Melichar
Magdalena Hudcová
Breast cancer is the most common type of solid tumors in women. Breast cancer treatment at each stage of the disease is based on results describing genetic changes present in the tumor cells. Since breast cancer is not a homogeneous disease...
Immunohistochemical assessment of HER2 protein in breast carcinomas - current status [0.03%]
乳腺癌中HER2蛋白的免疫组化评估-现状分析
Pavel Fabian
Pavel Fabian
The existing HER2 immunohistochemistry testing is currently experiencing changes in its scoring caused by the recent clinical trials results, especially DESTINY Breast 04 and 06. These trials demonstrated that any detectable immunohistochem...
Zuzana Slobodová
Zuzana Slobodová
Papillary breast lesions represent a morphologically and biologically diverse group of entities that include benign intraductal papillomas, papillomas with atypical ductal hyperplasia, with ductal or lobular carcinoma in situ, papillary duc...