Two Lactobacilli strains as adjuvant therapy in the management of irritable bowel syndrome: a randomized control trial [0.03%]
两种乳杆菌作为辅助治疗干预肠易激综合症：一项随机实验
Sadeel A Shanshal,Mohammad H Alsaaty,Harith Al-Qazaz et al.
Sadeel A Shanshal et al.
Alleviating the symptoms of irritable bowel syndrome (IBS) through the addition of probiotics to the treatment of IBS patients appears to be promising. The present randomized clinical trial seeks to assess the efficacy of a multi-strain pro...
Hyperferritinemia as a factor associated with poor prognosis in COVID-19 patients [0.03%]
高血清铁蛋白水平作为COVID-19患者预后不良的关联因素
Nuhad Mohammed Al-Dulaimi,Mahmood Jassim Mohammed,Saad T Mutlk et al.
Nuhad Mohammed Al-Dulaimi et al.
Worldwide, hundreds of millions of people have been infected with COVID-19 since December 2019; however, about 20% or less developed severe symptoms. The main aim of the current study was to assess the relationship between the severity of C...
Preparation and evaluation of spray-dried inhalable microparticles from carrier mixtures [0.03%]
载体混合物的喷雾干燥可吸入微粒的制备与评价
Andrea Peštálová,Karolína Molatová,Jan Gajdziok
Andrea Peštálová
The formulation of microparticles composed of a mixture of carriers represents an innovative approach for lung drug delivery of dry powder. The carriers used can significantly influence the properties of the microparticles, such as size, sh...
Therapeutic monitoring of antipsychotics with a focus on lurasidone and its dosing [0.03%]
抗精神病药物的治疗监测，重点关注鲁拉西酮及其剂量调整
Z Strašilová,M Turjap,J Juřica
Z Strašilová
Dose-response relationships are not fully understood for antipsychotics. Especially in the case of multimodal antipsychotics, these relationships cannot be simplified to the level of dopaminergic receptor occupancy alone. In general, for mo...
Synthesis, characterization, molecular docking studies of new alkyl derivatives of 5-(2-bromo-4-fluorophenyl)-4-ethyl-4H- -1,2,4-triazole-3-thiol [0.03%]
5-(2-溴-4-氟苯基)-4-乙基-4H-1，2，4-三唑并噻唑-3-硫醇的新取代烷基衍生物的合成、表征及分子对接研究
Roman Shcherbyna,Valerü Kalchenko,Sergii Kulish et al.
Roman Shcherbyna et al.
The main goal of this article is to present the results of the synthesis of new alkyl derivatives of 5-(2-bromo4-fluorophenyl)-4-ethyl-4H-1,2,4-triazole-3-thiol and molecular docking studies against COX-1 and COX-2. Previous studies have es...
Study of the anti-inflammatory properties of a thick extract of Tribulus terrestris L [0.03%]
白芙伏子草 Thick提取物的抗炎作用研究
Saida Yunusova,Yaroslav Rozhkovskyi,Bohdan Prystupa et al.
Saida Yunusova et al.
The most promising direction in the treatment of chronic prostatitis is the use of medicinal plants and preparations based on them, which contain natural compounds with a broad spectrum of pharmacological activity: anti-inflammatory, antimi...
Effect of digoxin, sodium valproate, and celecoxib on the cerebral cyclooxygenase pathway and neuron-specific enolase under the pentylenetetrazole-induced kindling in mice [0.03%]
地高辛、戊聚酷巴乙酸钠及塞来昔布对戊四氮痫灶法诱导的小鼠脑环氧化酶通路及相关神经特异性烯醇化酶的影响
Vadim Tsyvunin,Sergiy Shtrygol,Mariia Mishchenko et al.
Vadim Tsyvunin et al.
Neuroinflammation plays an important role in the pathogenesis of epilepsy, so it is necessary to clarify the influence of standard antiepileptic drugs as well as adjuvant agents (e.g., cardiac glycoside digoxin, which previously showed a cl...
Diazotization titrations in pharmacopoeial quality control of medicines and proposals for their revision in the European Pharmacopoeia [0.03%]
关于欧洲药典中官方药品质量控制中的重氮化滴定及其修订建议
Jan Šubert,Jozef Kolář,Jozef Čižmárik
Jan Šubert
Based on the data in the Ph. Eur., some other newer pharmacopoeias and published experimental papers propose to revise the text of Ph. Eur. 2.5.8. First, it is necessary to specify which of the electrometric methods should be used to indica...
General intravenous anesthetics - pharmacodynamics, pharmacokinetics and chiral properties [0.03%]
通用静脉麻醉药-药动学、药效学及手性属性
Ružena Čižmáriková,Ladislav Habala,Mário Markulia
Ružena Čižmáriková
In continuation of our published review on general inhalational anesthetics, the current article presents a survey of intravenous agents for general anaesthesia. From chemical point of view these compounds belong to structurally diverse cat...
František Šimon
František Šimon
Fridrich Jakub Fuker (1749-1805), a physician from Košice, is the author of works on medical topics, as well as works on social life. In addition to his medical practice, he also owned a pharmacy, and his short work on a universal preventi...