H P Nguyen,R Katta
H P Nguyen
First described in the context of diabetes, advanced glycation end products (AGEs) are formed through a type of non-enzymatic reaction called glycation. Increased accumulation of AGEs in human tissue has now been associated with end stage r...
Review
Skin therapy letter. 2015 Nov;20(6):1-5. DOI: 2015
D A Nowak,S M Wong
D A Nowak
Up to a third of dermatology outpatients have a significant psychiatric issue complicating their skin complaint. Although the ideal would frequently involve psychiatric assessment, those with comorbid mental illness often refuse psychiatric...
Actikerall™ (5-Fluorouracil 0.5% and Salicylic Acid 10%) Topical Solution for Patient-directed Treatment of Actinic Keratoses [0.03%]
艾克克拉（5-氟尿嘧啶0.5%和水杨酸10%）溶液治疗光照性角化病患者的用药指导说明书
H P Nguyen,J K Rivers
H P Nguyen
Actinic keratosis (AK), a common cutaneous lesion with the potential to transform into squamous cell carcinoma, has traditionally been treated with ablative and/or surgical procedures. Recently, a topical formulation combining 0.5% 5-fluoro...
A K Gupta,D Daigle
A K Gupta
Melanoma is an aggressive skin cancer with a generally poor prognosis at Stage III-IV disease. Traditionally, metastatic melanoma was treated by surgical resection, when possible, and with systemic chemotherapy. New developments in molecula...
Review
Skin therapy letter. 2016 Mar;21(2):6-9. DOI: 2016
Dupilumab, A Monoclonal Antibody for Atopic Dermatitis: A Review of Current Literature [0.03%]
Dupilumab——治疗特应性皮炎的单克隆抗体：综述当前文献
K Blakely,M Gooderham,K Papp
K Blakely
Atopic dermatitis results when aberrant barrier function and immune activation occur within the skin. Standard therapies for atopic dermatitis have fallen short, prompting efforts to discover novel therapeutics for this disease. Of these, d...
Review
Skin therapy letter. 2016 Mar;21(2):1-5. DOI: 2016
New antibiotics in the management of acute bacterial skin and skin structure infections [0.03%]
新型抗生素在急性细菌性皮肤和皮肤结构感染治疗中的应用
K Gleghorn,E Grimshaw,E K Kelly
K Gleghorn
Acute bacterial skin and skin-structure infections (ABSSSIs), often caused by aerobic gram-positive cocci, are most often mild-tomoderate infections that can easily be treated in an outpatient setting. With the rates of these infections sub...
M Gooderham,K Papp
M Gooderham
Phosphodiesterase 4 (PDE4) is a key enzyme in the regulation of immune responses of inflammatory diseases through degradation of the second messenger, cyclic adenosine 3',5'-monophosphate (cAMP). Apremilast, a selective PDE4 inhibitor, has ...
G Gupta,D Daigle,A K Gupta et al.
G Gupta et al.
The etiology of papulopustular rosacea (PPR) is not well understood yet appears to involve both the innate and adaptive immune response in addition to possible infestation with Demodex mites. Current treatments for PPR consist mainly of ant...
D Barlev,D B Eisen,A Alikhan
D Barlev
Hidradenitis suppurativa (HS) is a chronic disease of the follicular unit that often leads to marked impairment of quality of life and usually affects the axillary, perineum and inframammary regions resulting in tender subcutaneous nodules,...
L Guenther
L Guenther
The scalp is involved in up to 80% of individuals with psoriasis. Eighty percent of those with scalp psoriasis experience a negative impact on quality of life. Topical treatment with corticosteroids with or without vitamin D3 analogues is t...