Dustin H. Marks,Adam Friedman
Dustin H. Marks
Cannabinoids have demonstrated utility in the management of cancer, obesity, and neurologic disease. More recently, their immunosuppressive and anti-inflammatory properties have been identified for the treatment of several dermatologic cond...
Chronic Pruritus: A Review of Neurophysiology and Associated Immune Neuromodulatory Treatments [0.03%]
慢性瘙痒的神经生理学及相关的免疫神经调节治疗综述
J M Patel,H Dao Jr
J M Patel
Chronic pruritus remains a difficult condition to treat with many non-specific therapeutic options. Recent scientific discoveries have elucidated the physiology associated with pruritus. Combined with clinical and experimental trials with i...
Review
Skin therapy letter. 2018 Sep;23(5):5-9. DOI: 2018
J K Rivers,M R Copley,R Svoboda et al.
J K Rivers et al.
The Pigmented Lesion Assay (PLA) is a gene expression test that helps rule out melanoma and has the potential to reduce the need for surgical biopsies of atypical pigmented skin lesions. Utilizing a new technological platform for the non-in...
B Kuehl,N H Shear
B Kuehl
Most people with mild-to-moderate psoriasis manage their disease with topical therapies. However, adherence to topical treatment remains a challenge, as the daily application creates a significant treatment burden. New topical therapeutic o...
Review
Skin therapy letter. 2018 Jul;23(4):5-9. DOI: 2018
Alitretinoin: An Update of Real-World Evidence in The Management of Chronic Hand Dermatitis [0.03%]
阿利特林酸治疗慢性手部皮炎的真实世界证据更新研究
M J Gooderham
M J Gooderham
Chronic hand dermatitis is a debilitating inflammatory dermatosis that has a significant impact on the quality of life of those affected. Alitretinoin is an oral retinoid which has proven efficacy and safety in the treatment of chronic hand...
Review
Skin therapy letter. 2018 Jul;23(4):1-4. DOI: 2018
Janus Kinase Inhibitors: A Review of Their Emerging Applications in Dermatology [0.03%]
janus激酶抑制剂：在皮肤病学中新兴应用的回顾性研究
A Cinats,E Heck,L Robertson
A Cinats
The class of medications known as Janus kinase inhibitors block cytokine-mediated signaling via the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway, which plays an important role in immunoregulation and norm...
Review
Skin therapy letter. 2018 May;23(3):5-9. DOI: 2018
E P Westby,C Lynde,G Sussman
E P Westby
Histamine is a key inflammatory player in the pathogenesis of urticaria, a mast-cell-driven disease characterized clinically by the development of wheals, angioedema, or both. Changes to the management of chronic spontaneous urticaria have ...
Review
Skin therapy letter. 2018 May;23(3):1-4. DOI: 2018
A Review of Fabry Disease [0.03%]
法布雷病的评述
B Chan,D N Adam
B Chan
Fabry disease (FD) is an X-linked lysosomal storage disease. A lack of alpha-galactosidase activity results in the accumulation of globotriaosylceramide in cells of various systems, leading to multi-systemic effects. The cutaneous hallmark ...
Review
Skin therapy letter. 2018 Mar;23(2):4-6. DOI: 2018
S Rusta-Sallehy,M Gooderham,K Papp
S Rusta-Sallehy
Interleukin (IL)-17 is important in the pathophysiology of psoriasis and has proven to be an effective therapeutic target. Brodalumab, the third commercially available IL-17 antagonist, was approved by the US FDA in February 2017 for the tr...
Review
Skin therapy letter. 2018 Mar;23(2):1-3. DOI: 2018
Nathan M Johnson,Mariana A Phillips
Nathan M Johnson
Hereditary angioedema is characterized by severe, episodic edema of the subcutaneous and mucosal tissue. The disease carries significant morbidity and mortality due to involvement of the gastrointestinal tract and upper airway. Recent advan...
Review
Skin therapy letter. 2018 Jan;23(1):6-8. DOI: 2018