Forelimb Resistance Exercise Protects Against Neuromuscular Junction Denervation in the SOD1-G93A Rat Model of ALS [0.03%]
前肢抗阻运动可防止SOD1-G93A型ALS模型大鼠的神经肌肉接头去神经支配
Hiroshi Nishimune,Kimberly G Stanford,Jie Chen et al.
Hiroshi Nishimune et al.
Introduction: The symptoms of Amyotrophic Lateral Sclerosis (ALS) include muscle weakness and eventual paralysis. These symptoms result from denervation of the neuromuscular junction (NMJ) and motor neuron cell death in t...
Sex Differences in Stroke Risk Factors, Clinical Profiles, and In-Hospital Outcomes Among Stroke Patients Admitted to the Medical Ward of Dessie Comprehensive Specialized Hospital, Northeast Ethiopia [0.03%]
埃塞俄比亚东北德赛综合专科医院内科病房卒中患者的危险因素、临床特征及住院结局的性别差异
Hussen Abdu,Girma Seyoum
Hussen Abdu
Background: A stroke is a vascular accident that affects both men and women. The threat of stroke and outcome status differ between the sexes. Such data are lacking in Ethiopia. Therefore, this study assessed sex differen...
Wilfried Kuhn,Georg Karp,Thomas Müller
Wilfried Kuhn
Previous trials describe a decrease of vitamin D levels in patients with Parkinson's disease and relationships to clinical disease severity. This case control study found higher but not significant 25-OH-vitamin D plasma levels in patients ...
The Wahls Behavior Change Model for Complex Chronic Diseases: A Clinician's Guide [0.03%]
瓦尔斯行为改变模型在复杂慢性病中的应用：临床医师指南
Alaina N Elliott-Wherry,Jennifer E Lee,Amy M Pearlman et al.
Alaina N Elliott-Wherry et al.
Behavior change models are used to understand and intervene on health-related behaviors and outcomes. However, there is a gap in the literature regarding how to create and maintain behavior change in patients with complex chronic diseases s...
Istradefylline for OFF Episodes in Parkinson's Disease: A US Perspective of Common Clinical Scenarios [0.03%]
衣斯德拉菲林治疗帕金森病 OFF 事件：美国常见临床病例的视角
Stuart H Isaacson,Sagari Betté,Rajesh Pahwa
Stuart H Isaacson
The effective management of OFF episodes remains an important unmet need for patients with Parkinson's disease (PD) who develop motor complications with long-term levodopa therapy. Istradefylline is a selective adenosine A2A receptor antago...
Mechanisms of Action of Semen Ziziphi spinosae in the Treatment of Tourette Syndrome [0.03%]
桑枝提取物治疗抽动症的作用机制研究
Fei Fan,Fei Han,Long Hao
Fei Fan
Background: Semen Ziziphi spinosae, known as Suanzaoren (SZR) in Chinese, is a Chinese herbal medicine widely used in sedatives and tranquilizers. Although SZR is important for the clinical treatment of Tourette syndrome ...
Effectiveness of Respiratory Muscle Training on Respiratory Muscle Strength, Pulmonary Function, and Respiratory Complications in Stroke Survivors: A Systematic Review of Randomized Controlled Trials [0.03%]
卒中后患者呼吸肌训练有效性的系统综述：基于随机对照试验的研究进展
Sisay Deme,Dheeraj Lamba,Abayneh Alamer et al.
Sisay Deme et al.
Background: Stroke is the most common leading cause of mortality and related morbidities worldwide. After stroke, the motor function of extremities and spinal muscles is significantly impairment, but not only this, it als...
Ponesimod in the Treatment of Relapsing Forms of Multiple Sclerosis: An Update on the Emerging Clinical Data [0.03%]
奥纳西莫德治疗复发型多发性硬化症的临床数据更新
Serena Ruggieri,Maria Esmeralda Quartuccio,Luca Prosperini
Serena Ruggieri
Sphingosine 1-phosphate (S1P) receptors are bioactive lipid metabolites that bind five different types of receptors expressed ubiquitously in human body and mediate a broad range of biological functions. Targeting S1P receptors is nowadays ...
Potential Roles of Glucagon-Like Peptide-1 and Its Analogues in Dementia Targeting Impaired Insulin Secretion and Neurodegeneration [0.03%]
胰高血糖素样肽1及其类似物在痴呆发病机制中的潜在作用及靶向治疗缺陷胰岛素分泌和神经变性的作用
Sidharth Mehan,Sonalika Bhalla,Ehraz Mehmood Siddiqui et al.
Sidharth Mehan et al.
Dementia is a chronic, irreversible condition marked by memory loss, cognitive decline, and mental instability. It is clinically related to various progressive neurological diseases, including Parkinson's disease, Alzheimer's disease, and H...
Alberto Javier-Ormazábal,Montserrat González-Platas,Elena González-Sierra et al.
Alberto Javier-Ormazábal et al.
Introduction: Nowadays, a set of novel physiotherapy techniques have emerged, in which the physical agent used to try to reduce spasticity is applied percutaneously, specifically, through the patient's skin. The aim of th...