The relationship between the apolipoprotein E e4 allele and hippocampal magnetic resonance imaging volume in community-dwelling individuals with mild Alzheimer's disease [0.03%]
载脂蛋白E ε4等位基因与社区居住的轻度阿尔茨海默病患者的海马磁共振体积之间的关系
Bernard Walsh,Stuart Slater,Balakrishnan Nair et al.
Bernard Walsh et al.
Background: The degree of hippocampal magnetic resonance imaging (MRI) volume loss in Alzheimer's disease (AD) is commonly accepted as a marker of disease severity, yet remains expensive, unavailable, or not tolerated by ...
Matthew A Schreiber,Alexander W Thompson
Matthew A Schreiber
Depression in Parkinson's disease (PD) is common, and it appears to worsen the motor and cognitive progression of the disease, and limits the patient's quality of life. In this paper, we review the pharmacotherapy of depression in people wi...
Pathogenic mechanisms of neurodegeneration based on the phenotypic expression of progressive forms of immune-mediated neurologic disease [0.03%]
进行性免疫介导神经病理性状表达的神经退行性疾病发病机制
Michael C Levin,Sangmin Lee,Lidia A Gardner et al.
Michael C Levin et al.
Considering there are no treatments for progressive forms of multiple sclerosis (MS), a comprehensive understanding of the role of neurodegeneration in the pathogenesis of MS should lead to novel therapeutic strategies to treat it. Many stu...
Evaluation of tafamidis as first-line therapeutic agent for transthyretin familial amyloidotic polyneuropathy [0.03%]
评价转甲状腺素蛋白家族性淀粉样变性神经病一线治疗药物tafamidis的效果
Joel N Buxbaum
Joel N Buxbaum
Almost 100 mutations in the human transthyretin (TTR) gene cause the autosomal dominant disorders of familial amyloidotic polyneuropathy (FAP) and familial amyloidotic cardiomyopathy. While these have been clinically classified as separate ...
Kelly J Perkins,Kay E Davies
Kelly J Perkins
Duchenne muscular dystrophy (DMD), an allelic X-linked progressive muscle-wasting disease, is one of the most common single-gene disorders in the developed world. Despite knowledge of the underlying genetic causation and resultant pathophys...
Jeffrey S Shilt,Pennie S Seibert,Vivek Kadyan
Jeffrey S Shilt
Spasticity is characterized by velocity-dependent increase in tonic stretch reflexes and tendon jerks. Many people affected by spasticity receive late treatment, or no treatment, which greatly reduces the potential to regain full motor cont...
BG-12 and its potential for the prevention of relapse in multiple sclerosis [0.03%]
BG-12及其预防多发性硬化复发的潜力
Paolo Giannetti,Flavia Niccolini,Richard Nicholas
Paolo Giannetti
Multiple sclerosis (MS) arises from an immune attack on the central nervous system producing demyelination and axonal loss. Clinically the relapsing-remitting course is characterized by subacute onset of neurological symptoms usually with p...
New insights into the clinical evaluation of hereditary transthyretin amyloidosis patients: a single center's experience [0.03%]
遗传性转甲状腺素蛋白淀粉样变性患者的临床评估新见解：一家中心的经验
Ole B Suhr,Sandra Gustavsson,Victoria Heldestad et al.
Ole B Suhr et al.
Over the last decade, new medical treatment modalities have emerged based on increased insights into amyloid formation. With the increased possibilities for treatment of amyloidosis caused by transthyretin (TTR) amyloid deposits comes the n...
Krista Farrell,Roger A Barker
Krista Farrell
Currently the mainstay of Parkinson's disease (PD) therapy is the pharmacological replacement of the loss of the dopaminergic nigrostriatal pathway using drugs such as dopamine agonists and levodopa. Whilst these drugs effectively ameliorat...
Malin Wennström,Henrietta M Nielsen
Malin Wennström
Cell adhesion molecules (CAMs) mediate interactions between cells and their surroundings that are vital to processes controlling for cell survival, activation, migration, and plasticity. However, increasing evidence suggests that CAMs also ...