Pharmacokinetics of a Fixed-Dose Combination Product of Amlodipine, Losartan, Ezetimibe, and Rosuvastatin and Its Comparison with Co-administration of Four Individual Components in Healthy Participants [0.03%]
固定剂量组合药物氨氯地平、厄贝沙坦、依折麦布和罗苏伐他汀在健康参与者中的药代动力学及其与四种单药联合应用的比较
Jin-Woo Park,Hyewon Chung,Jong-Min Kim et al.
Jin-Woo Park et al.
Background and objective: This study aimed to assess and compare the pharmacokinetics, safety, and tolerability of a fixed-dose combination product (FDCP) comprising four different drugs (two antihypertensive drugs, amlod...
Normalization of Hemoglobin, Lactate Dehydrogenase, and Fatigue in Patients with Paroxysmal Nocturnal Hemoglobinuria Treated with Pegcetacoplan [0.03%]
佩加司他康治疗阵发性睡眠性血红蛋白尿患者的规范化疗、乳酸脱氢酶及疲劳感Normalization of Hemoglobin, Lactate Dehydrogenase, and Fatigue in Patients with Paroxysmal Nocturnal Hemoglobinuria Treated with Pegcetacoplan
Brian P Mulherin,Michael Yeh,Mohammed Al-Adhami et al.
Brian P Mulherin et al.
Background and objectives: We determined normalization rates for hemoglobin, lactate dehydrogenase (LDH), and fatigue in patients with paroxysmal nocturnal hemoglobinuria (PNH) treated with pegcetacoplan (PEG) in the PEGA...
Retrospective Assessment of Translational Pharmacokinetic-Pharmacodynamic Modeling Performance: A Case Study with Apitolisib, a Dual PI3K/mTOR Inhibitor [0.03%]
阿普利西布（一种PI3K/mTOR双重抑制剂）回顾性翻译药代动力学药效学模型性能评估：一个案例研究
Anita Moein,Jin Y Jin,Matthew R Wright et al.
Anita Moein et al.
Background and objectives: Despite significant progress in biomedical research, the rate of success in oncology drug development remains inferior to that of other therapeutic fields. Mechanistic models provide comprehensi...
Evaluation of Ornidazole Tablets Bioequivalence in Chinese Healthy Participants Under Fasted and Fed Conditions Using Pharmacokinetic Parameters [0.03%]
奥硝唑片在中国健康受试者空腹及餐后状态下的生物等效性研究——以药动学参数为评价指标
Yanrong Wang,Yuanyuan He,Weihong Li et al.
Yanrong Wang et al.
Background and objective: Ornidazole, the third generation of nitroimidazole derivatives after metronidazole and tinidazole, it exerts both bactericidal and antiprotozoal effects. The purpose of this study was to evaluate...
Future Perspectives of Pulmonary Arterial Hypertension: A Review of Novel Pipeline Treatments and Indications [0.03%]
肺动脉高压的未来展望——创新治疗方法与适应证综述
Maria Eugenia Novara,Enrica Di Martino,Brandon Stephens et al.
Maria Eugenia Novara et al.
Pulmonary arterial hypertension is characterized by elevated blood pressure and pathological changes in the pulmonary arterioles, leading to the development of right-heart failure and potentially fatal outcomes if left untreated. This revie...
Application of Transthoracic Echocardiography for Cardiac Safety Evaluation in the Clinical Development Process of Vaccines Against Streptococcus pyogenes [0.03%]
横断面超声心动图在A群链球菌疫苗心脏安全性评价中的应用研究过程
Usman Nakakana,Alimamy Serry-Bangura,Bassey Effiom Edem et al.
Usman Nakakana et al.
Superficial infections with Streptococcus pyogenes (Strep A), pharyngitis and impetigo can induce acute rheumatic fever, an autoimmune sequela manifesting mostly with arthritis and rheumatic carditis. Valvular heart damage can persist or ad...
Linezolid-Induced Thrombocytopenia in Patients with Renal Impairment: A Case Series, Review and Dose Advice [0.03%]
利奈唑胺致肾功能损害患者血小板减少症报道、综述及用药建议
S R E Laarhuis,C H M Kerskes,M R Nijziel et al.
S R E Laarhuis et al.
Background and objective: Oral linezolid is often used as alternative therapy for intravenous vancomycin. According to the current guidelines, no dose adjustment has to be made in case of renal impairment. Nevertheless, i...
Effect of Daridorexant on the Pharmacokinetics of Midazolam, and on the Pharmacokinetics and Pharmacodynamics of Warfarin in Healthy Male Subjects [0.03%]
达利奥雷ант对健康男性受试者中咪达唑仑的药代动力学以及华法林的药代动力学和药效学的影响
Isabelle Zenklusen,Jasper Dingemanse,Christian Reh et al.
Isabelle Zenklusen et al.
Background and objectives: Daridorexant, a dual orexin receptor antagonist was recently approved for the treatment of insomnia at doses up to 50 mg once per night. This study investigated the effect of single-dose and mul...
Clinical Trial
Drugs in R&D. 2024 Mar;24(1):97-108. DOI:10.1007/s40268-024-00456-8 2024
Bioequivalence Study of Tebipenem Pivoxil in Healthy Chinese Adults [0.03%]
特比培南酯在中国健康成年受试者中的生物等效性研究
Rui Hao,Yiming Shao,Sisi Lin et al.
Rui Hao et al.
Background and objective: Tebipenem pivoxil (TP) is a carbapenem and is applied against pneumonia, otitis media, and sinusitis. This study compared the pharmacokinetics (PK) and safety of a test (T) preparation and refere...
Case Report: Life-Threatening Fluoxetine-Linked Postoperative Bleeding Informed by Pharmacogenetic Evaluation [0.03%]
病例报告：药物基因组学评估告知的氟西汀相关的术后出血威胁生命
Sara Rogers,Patrick J Silva,George Udeani et al.
Sara Rogers et al.
Background: Selective serotonin reuptake inhibitors (SSRI) are commonly used for the treatment of depression and anxiety. Inhibition of serotonin reuptake in platelets increases bleeding risk in patients taking SSRIs. ...