Exploring the Relationship Between Atorvastatin and Memory Loss: A Comprehensive Analysis Integrating Real-World Pharmacovigilance and Mendelian Randomization [0.03%]
阿托伐他汀与记忆力下降关系研究：真实世界药物警戒和孟德尔随机化综合分析
Kaiqin Chen,Yongtai Chen,Hesen Huang
Kaiqin Chen
Background and objective: Atorvastatin is a drug widely used to prevent cardiovascular and cerebrovascular diseases. Current observational studies suggest that atorvastatin may be associated with cognitive dysfunction (es...
Demonstration of Physicochemical and Functional Similarity of Biosimilar Pegfilgrastim-cbqv to Pegfilgrastim [0.03%]
pegfilgrastim-cbqv与pegfilgrastim的理化及功能相似性验证研究
Henriette Kuehne,Janice M Davis,LeeAnne Merewether et al.
Henriette Kuehne et al.
Background: Pegfilgrastim-cbqv/CHS-1701 (UDENYCA®) (hereafter referred to as pegfilgrastim-cbqv) was approved in 2018 by the US Food and Drug Administration as a biosimilar for pegfilgrastim (Neulasta®) (hereafter refer...
Antibody-Drug Conjugates in the Pipeline for Treatment of Melanoma: Target and Pharmacokinetic Considerations [0.03%]
pipeline中用于治疗黑色素瘤的抗体药物偶联物：靶点和药代动力学考虑因素
Ina Lami,Andrew J Wiemer
Ina Lami
Melanoma is an aggressive, rapidly developing form of skin cancer that affects about 22 per 100,000 individuals. Treatment options for melanoma patients are limited and typically involve surgical excision of moles and chemotherapy. Survival...
A Randomized, Open-Label, Phase I, Single-Dose Study of Antisense Oligonucleotide, Vupanorsen, in Chinese Adults with Elevated Triglycerides [0.03%]
利索那肽阴道凝胶治疗糖尿病女性的 1/2 期临床试验
Xiaojie Wu,Jicheng Yu,Beikang Ge et al.
Xiaojie Wu et al.
Background: Vupanorsen is a GalNAc3-conjugated antisense oligonucleotide targeting angiopoietin-like 3 (ANGPTL3) mRNA shown to reduce atherogenic lipoproteins in individuals with dyslipidemia. ...
Olivia Lim,Eamonn Maher,Daniel D Miller
Olivia Lim
Background and objective: PD-1 inhibitors have revolutionized cancer therapies and are being used to treat an expanding array of cancers. To best serve patients, clinicians should be familiar with the spectrum of skin man...
Efficacy of Co-Crystal of Tramadol-Celecoxib (CTC) in Patients with Acute Moderate-to-Severe Pain: A Pooled Analysis of Data from Two Phase 3 Randomized Clinical Trials [0.03%]
对乙酰氨基酚-曲马多共晶在中重度急性疼痛患者中的疗效：两项三期随机临床试验数据的汇总分析
Richard Langford,Eugene R Viscusi,Adelaida Morte et al.
Richard Langford et al.
Background and objectives: New acute pain medications are needed that provide effective analgesia while minimizing side effects and opioid exposure. Clinical trials of co-crystal of tramadol-celecoxib (CTC) have demonstra...
Effects of Body Mass Index on Hypertriglyceridemia Associated with Oral Bexarotene Therapy: A Post Hoc Analysis of an Open-Label Comparative Clinical Study of Combined Bexarotene and Phototherapy Versus Bexarotene Monotherapy for Japanese Patients with Cutaneous T-Cell Lymphoma [0.03%]
体质指数对口服贝沙罗汀治疗相关高甘油三酯血症的影响：日本皮肤T细胞淋巴瘤患者开放式贝沙罗汀联合光疗对比单用贝沙罗汀临床研究的事后分析
Akimasa Sanagawa,Tomoaki Hayakawa,Aya Yamamoto et al.
Akimasa Sanagawa et al.
Background: Bexarotene, which has been approved for use in Japan since 2016, is an effective drug for cutaneous T-cell lymphoma; however, careful management is imperative because of its adverse events. We previously demon...
Safety and Efficacy of Lemborexant in Insomnia Patients: Results of a Postmarketing Observational Study of Dayvigo® Tablets [0.03%]
临床使用戴维goo治疗失眠患者的安全性和疗效：一项上市后观察研究
Kazuo Mishima,Kenichi Fujimoto,Akira Endo et al.
Kazuo Mishima et al.
Background and objective: A prospective, postmarketing observational study was conducted to evaluate the safety and efficacy of lemborexant (LEM) tablets in daily clinical practice in Japan. No other studies of a similar ...
Pharmacokinetics and Bioequivalence of Two Formulations of Azithromycin Tablets: A Randomized, Single-Dose, Three-Period, Crossover Study in Healthy Chinese Volunteers Under Fasting and Fed Conditions [0.03%]
两种阿奇霉素 tablets 制剂在中国健康受试者中单剂量给药绝对生物利用度与生物等效性研究：空腹及餐后状态下的随机、开放、交叉三期临床试验
Yingrong Chen,Libing Ye,Jue Mei et al.
Yingrong Chen et al.
Background and objective: Azithromycin is the first azalide antibiotic that is related to the macrolide family of antibiotics. Bioequivalence studies in China are initiated by the National Medical Products Administration ...
A Semi-Mechanistic Population Pharmacokinetic Model of Noscapine in Healthy Subjects Considering Hepatic First-Pass Extraction and CYP2C9 Genotypes [0.03%]
基于肝首过效应和CYP2C9基因型的 Norman 在健康受试者中的半机制群体药代动力学模型
Zhendong Chen,Max Taubert,Chunli Chen et al.
Zhendong Chen et al.
Introduction: Noscapine is a commonly used cough suppressant, with ongoing research on its anti-inflammatory and anti-tumor properties. The drug has a pronounced pharmacokinetic variability. ...