A Randomized, Open-Label, Phase I, Single-Dose Study of Antisense Oligonucleotide, Vupanorsen, in Chinese Adults with Elevated Triglycerides [0.03%]
利索那肽阴道凝胶治疗糖尿病女性的 1/2 期临床试验
Xiaojie Wu,Jicheng Yu,Beikang Ge et al.
Xiaojie Wu et al.
Background: Vupanorsen is a GalNAc3-conjugated antisense oligonucleotide targeting angiopoietin-like 3 (ANGPTL3) mRNA shown to reduce atherogenic lipoproteins in individuals with dyslipidemia. ...
Olivia Lim,Eamonn Maher,Daniel D Miller
Olivia Lim
Background and objective: PD-1 inhibitors have revolutionized cancer therapies and are being used to treat an expanding array of cancers. To best serve patients, clinicians should be familiar with the spectrum of skin man...
Efficacy of Co-Crystal of Tramadol-Celecoxib (CTC) in Patients with Acute Moderate-to-Severe Pain: A Pooled Analysis of Data from Two Phase 3 Randomized Clinical Trials [0.03%]
对乙酰氨基酚-曲马多共晶在中重度急性疼痛患者中的疗效：两项三期随机临床试验数据的汇总分析
Richard Langford,Eugene R Viscusi,Adelaida Morte et al.
Richard Langford et al.
Background and objectives: New acute pain medications are needed that provide effective analgesia while minimizing side effects and opioid exposure. Clinical trials of co-crystal of tramadol-celecoxib (CTC) have demonstra...
Effects of Body Mass Index on Hypertriglyceridemia Associated with Oral Bexarotene Therapy: A Post Hoc Analysis of an Open-Label Comparative Clinical Study of Combined Bexarotene and Phototherapy Versus Bexarotene Monotherapy for Japanese Patients with Cutaneous T-Cell Lymphoma [0.03%]
体质指数对口服贝沙罗汀治疗相关高甘油三酯血症的影响：日本皮肤T细胞淋巴瘤患者开放式贝沙罗汀联合光疗对比单用贝沙罗汀临床研究的事后分析
Akimasa Sanagawa,Tomoaki Hayakawa,Aya Yamamoto et al.
Akimasa Sanagawa et al.
Background: Bexarotene, which has been approved for use in Japan since 2016, is an effective drug for cutaneous T-cell lymphoma; however, careful management is imperative because of its adverse events. We previously demon...
Safety and Efficacy of Lemborexant in Insomnia Patients: Results of a Postmarketing Observational Study of Dayvigo® Tablets [0.03%]
临床使用戴维goo治疗失眠患者的安全性和疗效：一项上市后观察研究
Kazuo Mishima,Kenichi Fujimoto,Akira Endo et al.
Kazuo Mishima et al.
Background and objective: A prospective, postmarketing observational study was conducted to evaluate the safety and efficacy of lemborexant (LEM) tablets in daily clinical practice in Japan. No other studies of a similar ...
Pharmacokinetics and Bioequivalence of Two Formulations of Azithromycin Tablets: A Randomized, Single-Dose, Three-Period, Crossover Study in Healthy Chinese Volunteers Under Fasting and Fed Conditions [0.03%]
两种阿奇霉素 tablets 制剂在中国健康受试者中单剂量给药绝对生物利用度与生物等效性研究：空腹及餐后状态下的随机、开放、交叉三期临床试验
Yingrong Chen,Libing Ye,Jue Mei et al.
Yingrong Chen et al.
Background and objective: Azithromycin is the first azalide antibiotic that is related to the macrolide family of antibiotics. Bioequivalence studies in China are initiated by the National Medical Products Administration ...
A Semi-Mechanistic Population Pharmacokinetic Model of Noscapine in Healthy Subjects Considering Hepatic First-Pass Extraction and CYP2C9 Genotypes [0.03%]
基于肝首过效应和CYP2C9基因型的 Norman 在健康受试者中的半机制群体药代动力学模型
Zhendong Chen,Max Taubert,Chunli Chen et al.
Zhendong Chen et al.
Introduction: Noscapine is a commonly used cough suppressant, with ongoing research on its anti-inflammatory and anti-tumor properties. The drug has a pronounced pharmacokinetic variability. ...
Pharmacokinetics of a Fixed-Dose Combination Product of Amlodipine, Losartan, Ezetimibe, and Rosuvastatin and Its Comparison with Co-administration of Four Individual Components in Healthy Participants [0.03%]
固定剂量组合药物氨氯地平、厄贝沙坦、依折麦布和罗苏伐他汀在健康参与者中的药代动力学及其与四种单药联合应用的比较
Jin-Woo Park,Hyewon Chung,Jong-Min Kim et al.
Jin-Woo Park et al.
Background and objective: This study aimed to assess and compare the pharmacokinetics, safety, and tolerability of a fixed-dose combination product (FDCP) comprising four different drugs (two antihypertensive drugs, amlod...
Normalization of Hemoglobin, Lactate Dehydrogenase, and Fatigue in Patients with Paroxysmal Nocturnal Hemoglobinuria Treated with Pegcetacoplan [0.03%]
佩加司他康治疗阵发性睡眠性血红蛋白尿患者的规范化疗、乳酸脱氢酶及疲劳感Normalization of Hemoglobin, Lactate Dehydrogenase, and Fatigue in Patients with Paroxysmal Nocturnal Hemoglobinuria Treated with Pegcetacoplan
Brian P Mulherin,Michael Yeh,Mohammed Al-Adhami et al.
Brian P Mulherin et al.
Background and objectives: We determined normalization rates for hemoglobin, lactate dehydrogenase (LDH), and fatigue in patients with paroxysmal nocturnal hemoglobinuria (PNH) treated with pegcetacoplan (PEG) in the PEGA...
Retrospective Assessment of Translational Pharmacokinetic-Pharmacodynamic Modeling Performance: A Case Study with Apitolisib, a Dual PI3K/mTOR Inhibitor [0.03%]
阿普利西布（一种PI3K/mTOR双重抑制剂）回顾性翻译药代动力学药效学模型性能评估：一个案例研究
Anita Moein,Jin Y Jin,Matthew R Wright et al.
Anita Moein et al.
Background and objectives: Despite significant progress in biomedical research, the rate of success in oncology drug development remains inferior to that of other therapeutic fields. Mechanistic models provide comprehensi...