Bioequivalence Study of Two Formulations of Flunarizine Hydrochloride Capsules in Healthy Chinese Subjects Under Fasting and Fed Conditions [0.03%]
两种盐酸氟桂利嗪胶囊制剂在中国健康受试者空腹及餐后条件下的生物等效性研究
Yinglin Yang,Jiejing Kai,Duo Lv et al.
Yinglin Yang et al.
Background and objectives: Flunarizine, a selective calcium channel blocker with vasodilatory and neuroprotective effects, is a mainstay for migraine prophylaxis and vertigo management. This study aimed to compare the bio...
Drugs for Procedural Sedation and Analgesia in Children: A Systematic Review and Meta-analysis [0.03%]
儿童镇静止痛药物的系统性回顾和元分析
Sandrella Hamdan,Samuel Adelou,Sébastien Jungo et al.
Sandrella Hamdan et al.
Background and objectives: Performing medical procedures on children can often be challenging because of the anxiety that these procedures may induce, the need for immobility that they may require, or age-related developm...
Assessment of Pharmacokinetics and Safety with Bioequivalence of the Nitroglycerin Sublingual Tablets of Two Formulations in Chinese Healthy Subjects: A Bioequivalence Study [0.03%]
评价两种硝酸甘油舌下片的人体生物等效性及其在中国健康志愿者中的药代动力学和安全性：一项生物等效性研究
Qinjiao Fu,Chunqi Huang,Yuan Yuan et al.
Qinjiao Fu et al.
Background and objective: Nitroglycerin, a cornerstone therapy for acute angina pectoris, achieves rapid symptom relief through sublingual administration by bypassing hepatic first-pass metabolism. This study aimed to inv...
Effect of Severe Renal Impairment on Dordaviprone (ONC201) Pharmacokinetics [0.03%]
重度肾功能不全对Dordaviprone（ONC201）药代动力学的影响
Shamia L Faison,Joelle Batonga,Thangam Arumugham et al.
Shamia L Faison et al.
Background and objective: Dordaviprone (ONC201) is a novel small molecule with antitumor effects in patients with glioma. The major elimination pathway of dordaviprone is metabolism via cytochrome P450 (CYP) 3A4. This stu...
A Bioequivalence Study of Recombinant Human Follicle-Stimulating Hormone Injection Versus Recombinant Human Follitropin For Injection in Healthy Chinese Adult Women [0.03%]
重组人促卵泡素注射液I与重组人 follitropin α注射液在中国健康成年女性中的生物等效性研究
Jigang Zhang,Mingjian Zhang,Wenyuan Xue et al.
Jigang Zhang et al.
Background and objective: This study aimed to evaluate the bioequivalence of a novel prefilled recombinant human follicle-stimulating hormone (rh-FSH) injection (GenSci008) compared with the existing rh-FSH for injection ...
In-Vitro Comparison of Physical Characteristics, Enzyme Content, and Release Kinetics of Pancreatic Enzyme Preparations Available in Europe and Canada [0.03%]
欧洲和加拿大销售的胰酶制品的体外物理性质、酶含量及释放曲线比较
Sven Hartmann,Jonas Rosendahl,Amy Todd et al.
Sven Hartmann et al.
Introduction: Commercially available pancreatic enzyme replacement therapy (PERT) preparations differ significantly in their physical and enzyme properties, raising concern about the interchangeability of these preparatio...
Demonstrating Bioequivalence for a Lumacaftor Monosubstance Formulation Versus Orkambi® (Lumacaftor/Ivacaftor) in Healthy Subjects [0.03%]
在健康受试者中验证卢卡前列素单药制剂与奥尔卡姆比(卢卡前列素/伊伐前列素)的生物等效性
Alexandra Papaelias,Darcy Lidington,Steffen-Sebastian Bolz
Alexandra Papaelias
Background and objective: Lumacaftor is an active ingredient in the US Food and Drug Administration-approved combination medication Orkambi®, which is used for treating cystic fibrosis. Experimental evidence suggests tha...
Pharmacokinetic Comparison of Novel Tablet-in-Tablet and Conventional Ketorolac Tromethamine Tablets in Beagle Dogs [0.03%]
新型缓释双层片与酮咯酸氨化钠普通片在比格犬体内药代动力学比较研究
Xiang-Yang Xie,Yuan Zeng,Zhi-Long Chen et al.
Xiang-Yang Xie et al.
Background and objective: Ketorolac tromethamine (KT), a nonsteroidal anti-inflammatory drug (NSAID) and cyclooxygenase inhibitor, is commonly used for the management of moderate to severe pain. The objective of this stud...
Systematic Review and Meta-analysis of the Clinical Efficacy of Octreotide in Combination with Ulinastatin in the Treatment of Acute Pancreatitis [0.03%]
奥曲肽联合乌司他丁治疗急性胰腺炎的临床疗效系统评价和meta分析
Long-Xun Zhu,Yong Chen,Xiang-Fan Chen et al.
Long-Xun Zhu et al.
Background and objectives: Acute pancreatitis (AP) is a serious disease characterized by local inflammatory responses in the pancreas. The annual incidence rate of acute pancreatitis is 4.9-73.4 per 100,000 people. Among ...
Opinion of the Italian Association of Myology on Ataluren for the Treatment of Nonsense Mutation Duchenne Muscular Dystrophy [0.03%]
意大利肌病协会关于ataluren治疗无义突变型杜氏肌营养不良症的意见
Luca Bello,Pietro Riguzzi,Emilio Albamonte et al.
Luca Bello et al.
The Italian Duchenne muscular dystrophy expert clinicians, gathered in the Italian Association of Myology (AIM), intend to express a position against the suspension of the Marketing Authorization of ataluren (Translarna®) for the treatment...