Risk Factors for Septic Shock After Irinotecan-Containing Chemotherapy: An Exploratory Case-Control Study [0.03%]
伊立替康相关性败血症休克的危险因素研究：病例对照探索性分析
Maki Umemiya,Yoshihide Inayama,Eiji Nakatani et al.
Maki Umemiya et al.
Background and objectives: Irinotecan sometimes causes lethal septic shock but the risk factors remain unclear. This retrospective case-control study explored the potential risk factors for septic shock following irinotec...
Correction: Association between Acid-Suppressive Drugs and Clinical Outcomes in Patients with Nonvalvular Atrial Fibrillation [0.03%]
关于酸抑制剂与非瓣膜性房颤患者临床结局之间关联的更正研究
Hideki Arai,Shinichiro Ueda,Kazutaka Uchida et al.
Hideki Arai et al.
Published Erratum
Drugs in R&D. 2022 Sep;22(3):223. DOI:10.1007/s40268-022-00401-7 2022
Study of the Stability of Sandoz Rituximab Biosimilar Rixathon®/Riximyo® When Subjected for up to 21 Days to Ambient Storage [0.03%]
室温下长达21天的储存条件对山德士利妥昔单抗类似药(Rixathon®/Riximyo®)稳定性的影响研究
Roman Borišek,André Mischo,Ida Šmid
Roman Borišek
Aim: The purpose of this study was to evaluate the extended physicochemical and biological stability of Sandoz Rixathon®/Riximyo® (SDZ-RTX) after exposure to out-of-fridge (OOF) conditions. ...
Antiplatelets Versus Anticoagulation in Cervical Artery Dissection: A Systematic Review and Meta-analysis of 2064 Patients [0.03%]
关于椎基底动脉夹层的2064例患者系统性回顾和荟萃分析：抗血小板治疗与抗凝治疗的效果比较
Abdulrahman Ibrahim Hagrass,Bashar Khaled Almaghary,Mohamed Abdelhady Mostafa et al.
Abdulrahman Ibrahim Hagrass et al.
Background and objectives: In young people aged < 50 years, cervical artery dissection (CeAD) is among the most common causes of stroke. Currently, there is no consensus regarding the safest and most effective antithrombo...
Meta-Analysis
Drugs in R&D. 2022 Sep;22(3):187-203. DOI:10.1007/s40268-022-00398-z 2022
Effectiveness and Safety of Upadacitinib in the Treatment of Moderate-Severe Atopic Dermatitis: A Multicentric, Prospective, Real-World, Cohort Study [0.03%]
乌帕替尼治疗中重度特应性皮炎的疗效和安全性：一项多中心、前瞻性、真实世界队列研究
Andrea Chiricozzi,Niccolò Gori,Alessandra Narcisi et al.
Andrea Chiricozzi et al.
Background: The efficacy and safety of upadacitinib in atopic dermatitis (AD) have been defined in clinical trials, but no real-world data are currently available. We aimed to assess the safety and effectiveness of upadac...
Bioavailability of Oniria®, a Melatonin Prolonged-Release Formulation, Versus Immediate-Release Melatonin in Healthy Volunteers [0.03%]
评估安睿释®（缓释褪黑素制剂）与速释褪黑素在健康志愿者中的生物利用度研究
Manuel Román Martinez,Eva García Aguilar,Samuel Martin Vílchez et al.
Manuel Román Martinez et al.
Background: Melatonin is an endogenous substance which plays a key role in sleep induction by reducing sleep onset latency; it has been approved by the European Food Safety Authority as a food supplement for exogenous adm...
Clinical Trial
Drugs in R&D. 2022 Sep;22(3):235-243. DOI:10.1007/s40268-022-00394-3 2022
Association between Acid-Suppressive Drugs and Clinical Outcomes in Patients with Nonvalvular Atrial Fibrillation [0.03%]
非瓣膜性房颤患者使用抑酸剂与临床结局的相关性分析
Hideki Arai,Shinichiro Ueda,Kazutaka Uchida et al.
Hideki Arai et al.
Purpose: Acid-suppressive drugs (ASDs) are often prescribed for patients with nonvalvular atrial fibrillation (NVAF) taking oral anticoagulants (OACs). However, the risk-benefit balance of ASDs prescription for patients w...
Analysis of the US Safety Data for Edaravone (Radicava®) From the Third Year After Launch [0.03%]
edaravone（radicava®）上市三年后的美国安全数据回顾性分析
Angela Genge,Benjamin Rix Brooks,Björn Oskarsson et al.
Angela Genge et al.
Background: Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neuromuscular disease with no curative therapies. Edaravone (Radicava®) (Mitsubishi Tanabe Pharma Corporation, Tokyo, Japan), approved in the Uni...
Evaluation of the Effect of Food on the Pharmacokinetics of SHR6390, An Oral CDK4/6 Inhibitor, in Healthy Volunteers [0.03%]
评估食物对健康志愿者中口服CDK4/6抑制剂SHR6390药代动力学影响的研究
Yan-Ping Liu,Ming-Hui Hu,Ping-Ping Lin et al.
Yan-Ping Liu et al.
Background and introduction: SHR6390 is a new developed highly effective and selective small-molecule oral CDK4/6 inhibitor. We aimed to evaluate the effect of food on the pharmacokinetics of SHR6390 tablets. ...
Randomized Controlled Trial
Drugs in R&D. 2022 Jun;22(2):175-182. DOI:10.1007/s40268-022-00390-7 2022
Hydroxychloroquine Blood Concentrations Can Be Clinically Relevant Also After Drug Discontinuation [0.03%]
羟氯喹浓度在停药后仍可能具有临床相关性
Simona De Gregori,Francesco Falaschi,Alessia Ballesio et al.
Simona De Gregori et al.
Background and objective: Hydroxychloroquine was widely used during the severe acute respiratory syndrome coronavirus 2 pandemic as an antiviral drug. Most previous pharmacokinetic/pharmacodynamic studies on hydroxychloro...