Appraisal of microbial evolution to commensalism and pathogenicity in humans [0.03%]
微生物与人类共生及致病的进化评估
Asit Ranjan Ghosh
Asit Ranjan Ghosh
The human body is host to a number of microbes occurring in various forms of host-microbe associations, such as commensals, mutualists, pathogens and opportunistic symbionts. While this association with microbes in certain cases is benefici...
Medical management of ulcerative colitis with a specific focus on 5-aminosalicylates [0.03%]
溃疡性结肠炎的药物治疗——以柳氮磺胺吡啶类为例
Hugh James Freeman
Hugh James Freeman
Medical management of ulcerative colitis has continued to evolve over more than half of a century. Perhaps, the important advance was the development of sulfasalazine, a drug initially used for the treatment of inflammatory joint disease an...
Proton Pump Inhibitor use in Hospitalized Patients: Is Overutilization Becoming a Problem? [0.03%]
住院患者的质子泵抑制剂使用情况：过度使用正成为问题吗？
Cheryl Durand,Kristine C Willett,Alicia R Desilets
Cheryl Durand
Proton pump inhibitors (PPIs) are among the most common classes of medications prescribed. Though they were previously thought of as safe, recent literature has shown risks associated with their use including increased risk for Clostridium ...
A complete resolution of sialadenitis induced by iodine containing contrast with intravenous dexamethasone infusion [0.03%]
静脉注射地塞米松完全治愈碘对比剂引起的唾液腺炎
Homam Alkaied,Kassem Harris,Basem Azab et al.
Homam Alkaied et al.
Salivary gland enlargement following the administration of iodine is an extremely rare event, and the pathophysiology of iodine-induced sialadenitis is not yet fully known. The onset of symptoms can start within a few minutes to five days a...
Pantoprazole for the treatment of peptic ulcer bleeding and prevention of rebleeding [0.03%]
Pantoprazole治疗消化性溃疡出血及预防再出血
Christo J van Rensburg,Susan Cheer
Christo J van Rensburg
Adding proton pump inhibitors (PPIs) to endoscopic therapy has become the mainstay of treatment for peptic ulcer bleeding, with current consensus guidelines recommending high-dose intravenous (IV) PPI therapy (IV bolus followed by continuou...
Intestinal metaplasia and the risk of gastric cancer in an immigrant asian population [0.03%]
肠上皮内陷与亚洲移民胃癌发病风险之间的关系
Amir Abadir,Catherine Streutker,Christine Brezden-Masley et al.
Amir Abadir et al.
The development of intestinal metaplasia (IM) has been purported to be a critical step in the pathogenesis of gastric cancer. However, the natural history of IM in migrant human populations has not been well elucidated. The purpose of this ...
Hoonmo L Koo,Saman Sabounchi,David B Huang et al.
Hoonmo L Koo et al.
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by abdominal pain and altered bowel habits in the absence of specific organic pathology. Although the underlying pathogenesis of IBS is not well-understood, ...
Lubiprostone for the treatment of adult women with irritable bowel syndrome with constipation [0.03%]
鲁比前列酮治疗成人便秘性肠易激综合征患者的疗效和安全性：一项随机、双盲、安慰剂平行对照试验
Mahmoud Soubra,Ron Schey
Mahmoud Soubra
Irritable bowel syndrome with constipation (IBS-C) affects approximately 5% of the population in western countries. The majority of those afflicted are women. Symptoms are often detrimental to the individual's quality of life and incur high...
Patient adherence and efficacy of certolizumab pegol in the management of Crohn's disease [0.03%]
-certolizumab治疗克罗恩病的患者依从性及疗效分析
Wojciech Blonski,Anna M Buchner,Gary R Lichtenstein
Wojciech Blonski
Treatment with Anti-Tumor Necrosis Factor (anti-TNF) therapy has become a mainstay of therapy for patients with CD who are unresponsive to conventional medical management. Currently there are three anti-TNFα antibodies that have been appro...
Siu-Tong Law,Sin Chuen Chiu
Siu-Tong Law
Protein-losing enteropathy (PLE) is a rare syndrome of gastrointestinal protein loss that may complicate a variety of diseases. The primary causes can be divided into erosive gastrointestinal disorders, nonerosive gastrointestinal disorders...