Prevalence, Morphological Types, and Associated Factors of Neonatal Anemia at a Rural Referral Hospital, Uganda [0.03%]
乌干达农村转诊医院新生儿贫血的流行率、形态类型及其相关因素
Martha Amoding,Joachim Ndawula,Bright Hajusu et al.
Martha Amoding et al.
Purpose: This study aimed to determine the prevalence, morphological classification, and factors associated with anemia among neonates at Soroti Regional Referral Hospital neonatal unit. ...
A Phase 1/2, Open-Label, Single-Dose, Multicenter Study to Evaluate the Pharmacokinetics and Safety of Human Plasma-Derived Protein C Concentrate in Japanese Patients with Severe Congenital Protein C Deficiency (SCPCD) [0.03%]
一项评价人血浆蛋白C浓缩剂在日本严重遗传性蛋白C缺乏症患者中的药代动力学和安全性的Ⅰ/Ⅱ期、开放标签、单次给药多中心研究
Katsuyoshi Koh,Keiji Nogami,Harumi Kakuda et al.
Katsuyoshi Koh et al.
Purpose: Severe congenital protein C deficiency (SCPCD) is a rare, life-threatening disorder. Plasma-derived protein C concentrate is recommended for the acute and long-term management of SCPCD; however, data in Japanese ...
Systematic Literature Review of the Economic and Quality of Life Burden of Congenital and Immune-Mediated Thrombotic Thrombocytopenic Purpura [0.03%]
关于先天性和免疫介导的血栓性血小板减少性紫癜的经济和生活质量负担的系统文献回顾
Harneet Kaur,Debjit Ghoshal,Inderpreet Singh Khurana
Harneet Kaur
Background: Thrombotic thrombocytopenic purpura (TTP) is a life-threatening blood disorder resulting from ADAMTS13 deficiency, caused by mutations in the ADAMTS13 gene in congenital TTP (cTTP), and by neutralizing antibod...
Optimizing Care in Patients with Paroxysmal Nocturnal Hemoglobinuria: Managing Suboptimal Response and Uncontrolled Disease [0.03%]
优化阵发性夜间血红蛋白尿患者的治疗：应对亚临床反应和不受控制的疾病
Marc Bienz,Monika Oliver,Catherine Sperlich et al.
Marc Bienz et al.
The treatment of patients with PNH has been revolutionized by terminal complement C5 inhibitors, which control intravascular hemolysis and thrombosis, reduce morbidity and mortality, and improve life expectancy to that approaching people wi...
Current Status of Clinical Gene Therapy for Hemophilia and Globin Disorders [0.03%]
血友病和珠蛋白生成障碍性贫血的临床基因治疗现状
Rebecca Winkler,Ishan Herath,Radoslaw Kaczmarek et al.
Rebecca Winkler et al.
In the last few years, gene therapy, holding the promise for long-term disease correction through a one-time treatment, has transitioned from experimental research to approved medicine. Several gene therapies are now available for congenita...
Haematological Profile of Patients with Sickle Cell Disease in the Acholi Sub-Region, Uganda [0.03%]
乌干达阿乔利地区的镰状细胞病患者的血液学谱型
Silvia Awor,Jimmyy Opee,Denis Ocaya et al.
Silvia Awor et al.
Background: Sickle cell disease (SCD) is a genetic blood disorder most prevalent in Eastern and Western Africa. With the high prevalence of SCD in northern Uganda, we set out to document the haematological profile of pati...
Research Progress on Transitional Care for Hemophilia Patients from Pediatric to Adult Services: Focusing on Disease Severity and Care Continuity [0.03%]
血友病患儿至成人期过渡照护的研究进展：重视疾病严重程度和护理连续性
Siting Wu,Chunli Wang,Dan Li et al.
Siting Wu et al.
Hemophilia is a lifelong coagulation disorder with varying severity levels, which significantly impacts management strategies. The transition period from pediatric to adult medical system represents a critical stage for ensuring continuous ...
Development and Validation of an Interpretable Machine Learning Model for Predicting Thrombocythemia Risk During Third Generation Cephalosporin Therapy [0.03%]
第三代头孢菌素治疗期间开发和验证预测血小板减少风险的可解释机器学习模型
Kailei Du,Maofeng Wang,Ping Yu
Kailei Du
Objective: Third-generation cephalosporins are widely used for severe infections but carry thrombocythemia risks complicating therapeutic decisions. Current predictive tools lack accuracy and clinical interpretability. Th...
Risk Factors for Post-Operative Blood Transfusion and Association with Outcomes in Hip Fracture Surgery [0.03%]
影响髋部骨折手术后输血的因素及其结局风险的关联性分析
Lou&#x;i Al-Husinat,Fadi Haddad,Sarah Al Sharie et al.
Lou&#x;i Al-Husinat et al.
Background: Blood transfusion during hip fracture surgery can significantly influence patient outcomes. This study aimed to identify risk factors for post-operative blood transfusions and their impact on clinical outcomes...
Resolving Incompatible Blood Cross-Matching: The Role of 37°C Water Bath in Transfusion Safety [0.03%]
37℃水浴在输血安全中的作用：解决不相容的交叉配血问题
Junling Han,Hongmei Niu,Fuqian Zhao et al.
Junling Han et al.
Background: Incompatible cross-matching at room temperature can delay critical blood transfusions. We report that red cells from patients requiring blood transfusion agglutinated after cross-matching at room temperature, ...