Athina Markou,Martha Zavridou,Evi S Lianidou
Athina Markou
Lung cancer is a leading cause of cancer death, and late diagnosis is one of the most important reasons for the high mortality rate. microRNAs (miRNAs) are key players in gene regulation and therefore in tumorigenesis. As far as lung carcin...
Khashayar Esfahani,Victor Cohen
Khashayar Esfahani
Lung cancer remains the most lethal cancer, with over 160,000 annual deaths in the USA alone. Over the past decade, the discovery of driver mutations has changed the landscape for the treatment of non-small-cell lung cancer (NSCLC). Targete...
Nutrition support and dietary interventions for patients with lung cancer: current insights [0.03%]
肺癌患者的营养支持和饮食干预：当前见解
Nicole Kiss
Nicole Kiss
Malnutrition and weight loss are prevalent in patients with lung cancer. The impact of malnutrition on patients with cancer, and specifically in patients with lung cancer, has been demonstrated in a large number of studies. Malnutrition has...
Noriaki Sunaga,Kyoichi Kaira
Noriaki Sunaga
Epiregulin (EREG) belongs to the ErbB family of ligands. EREG binds to EGFR and ErbB4 receptor and stimulates homodimers of EGFR and ErbB4 in addition to all possible heterodimeric ErbB complexes, resulting in the activation of downstream s...
Combination chemotherapy of gemcitabine and vinorelbine for pretreated non-small-cell lung cancer: a retrospective study [0.03%]
吉西他滨联合长春瑞滨治疗晚期非小细胞肺癌的回顾性分析
Seigo Minami,Yoshitaka Ogata,Suguru Yamamoto et al.
Seigo Minami et al.
Background: Advanced non-small-cell lung cancer (NSCLC) eventually progresses after first-line chemotherapy, and usually requires salvage treatment. Although neither gemcitabine nor vinorelbine is approved as a candidate ...
Shipra Gandhi,Hongbin Chen,Yujie Zhao et al.
Shipra Gandhi et al.
Non-small-cell lung cancer (NSCLC) is one of the leading causes of cancer deaths, both within the US and worldwide. There have been major treatment advances in NSCLC over the past decade with the discovery of molecular drivers of NSCLC, whi...
María González-Cao,Niki Karachaliou,Santiago Viteri et al.
María González-Cao et al.
Increased understanding of tumor immunology has led to the development of effective immunotherapy treatments. One of the most important advances in this field has been due to pharmacological design of antibodies against immune checkpoint in...
Levi Barse,Maurizio Bocchetta
Levi Barse
Notch signaling plays a pivotal role during embryogenesis. It regulates three fundamental processes: lateral inhibition, boundary formation, and lineage specification. During post-natal life, Notch receptors and ligands control critical cel...
Profile of ceritinib in the treatment of ALK+ metastatic non-small-cell lung cancer [0.03%]
克唑替尼治疗ALK阳性的转移性非小细胞肺癌患者的疗效分析
Mark W Burns,Eric S Kim
Mark W Burns
Lung cancer has become one of the leading causes of death in both men and women in the United States, with approximately 230,000 new cases and 160,000 deaths each year. Approximately 80% of lung cancer patients are diagnosed with non-small-...
Ross A Okimoto,Trever G Bivona
Ross A Okimoto
The AXL receptor tyrosine kinase and its ligand, Gas6, regulate key processes in lung cancer growth, metastasis, and epithelial-mesenchymal transition-associated drug resistance. Gas6 and AXL expression have been correlated with poor progno...