Bioinformatic Dissecting of TP53 Regulation Pathway Underlying Butyrate-induced Histone Modification in Epigenetic Regulation [0.03%]
丁酸介导表观遗传修饰的生物信息分析及对TP53调控通路的影响研究
Cong-Jun Li,Robert W Li
Cong-Jun Li
Butyrate affects cell proliferation, differentiation, and motility. Butyrate inhibits histone deacetylase (HDAC) activities and induces cell-cycle arrest and apoptosis. TP53 is one of the most active upstream regulators discovered by ingenu...
Epigenetics of autoantigens: new opportunities for therapy of autoimmune diseases [0.03%]
自身抗原的表观遗传学：自身免疫性疾病治疗的新机遇
Marko Radic,Sylviane Muller
Marko Radic
The field of epigenetics requires that traditional divisions between scientific disciplines give way to cross-fertilization of concepts and ideas from different areas of investigation. Such is the case with research in autoimmunity. Recent ...
Changes in methylation patterns of kiss1 and kiss1r gene promoters across puberty [0.03%]
青春期Kiss1和Kiss1r基因启动子甲基化模式的变化
Amanda K Wyatt,Monika Zavodna,Jean L Viljoen et al.
Amanda K Wyatt et al.
The initiation of mammalian puberty is underpinned by an increase in Kisspeptin (Kiss1) signaling via its receptor (Kiss1r/GPR54) on gonadotropin-releasing hormone (GnRH) neurons. Animals and humans with loss-of-function mutations in Kiss1 ...
Cong-Jun Li
Cong-Jun Li
DNA methylation is a major epigenetic regulatory mechanism for gene expression and cell differentiation. Until recently, it was still unclear how unmethylated regions in mammalian genomes are protected from de novo methylation and whether o...
Unexplored potentials of epigenetic mechanisms of plants and animals-theoretical considerations [0.03%]
植物和动物表观遗传机制的潜力探索——理论思考
Istvan Seffer,Zoltan Nemeth,Gyula Hoffmann et al.
Istvan Seffer et al.
Morphological and functional changes of cells are important for adapting to environmental changes and associated with continuous regulation of gene expressions. Genes are regulated-in part-by epigenetic mechanisms resulting in alternating p...
Loss of Imprinting of IGF2 Gene in the Chorionic Tissues of Spontaneously Eliminated Human Embryos [0.03%]
人胚囊组织中自发丢失的胚胎IGF2基因印记
Danuta Zastavna,Halyna Makukh,Bogdan Tretjak et al.
Danuta Zastavna et al.
Insulin-like growth factor-2 (IGF-2) is a mitogen, growth and differentiation modulator for many cell types. It is mainly expressed during the prenatal development, and its activity strongly depends on the genomic imprinting. Genomic imprin...
Epigenetic effect of chronic stress on dopamine signaling and depression [0.03%]
慢性应激对多巴胺信号传导及抑郁的表观遗传学作用
Sofia Moriam,Mahbub E Sobhani
Sofia Moriam
Because of the complex causal factors leading to depression, epigenetics is of considerable interest for the understanding effect of stress in depression. Dopamine is a key neurotransmitter important in many physiological functions, includi...
Acute psychosocial stress-mediated changes in the expression and methylation of perforin in chronic fatigue syndrome [0.03%]
急性心理社会压力介导的变化慢性疲劳综合症中穿孔素的表达和甲基化
Virginia R Falkenberg,Toni Whistler,Janna R Murray et al.
Virginia R Falkenberg et al.
Perforin (PRF1) is essential for immune surveillance and studies report decreased perforin in chronic fatigue syndrome (CFS), an illness potentially associated with stress and/or infection. We hypothesize that stress can influence regulatio...
UHRF1 Links the Histone code and DNA Methylation to ensure Faithful Epigenetic Memory Inheritance [0.03%]
UHRF1连接组蛋白代码和DNA甲基化以确保忠实的表观遗传记忆继承
Christian Bronner,Guy Fuhrmann,Frédéric L Chédin et al.
Christian Bronner et al.
Epigenetics is the study of the transmission of cell memory through mitosis or meiosis that is not based on the DNA sequence. At the molecular level the epigenetic memory of a cell is embedded in DNA methylation, histone post-translational ...