A STAT6 Intronic Single-Nucleotide Polymorphism is Associated with Clinical Malaria in Ghanaian Children [0.03%]
冈比亚儿童中STAT6内含子多态性与临床疟疾相关性研究
Daniel Amoako-Sakyi,Selorme Adukpo,Kwadwo A Kusi et al.
Daniel Amoako-Sakyi et al.
Malaria pathogenesis may be influenced by IgE responses and cytokine cross-regulation. Several mutations in the IL-4/STAT6 signaling pathway can alter cytokine cross-regulation and IgE responses during a Plasmodium falciparum malarial infec...
Estrogen Receptor Alpha (ESR1) Single-Nucleotide Polymorphisms (SNPs) Affect Malignant Melanoma Susceptibility and Disease Course [0.03%]
雌激素受体α（ESR1）单核苷酸多态性影响恶性黑色素瘤的易感性和病程
Hanna Glatthaar,Judith Katto,Thomas Vogt et al.
Hanna Glatthaar et al.
The incidence of malignant melanoma in the developed world is continuously increasing. We conducted a case-control study in order to evaluate the association between each of the four estrogen receptor alpha polymorphisms (ESR1 single-nucleo...
Alkaline Phosphatase-Positive Immortal Mouse Embryo Fibroblasts Are Cells in a Transitional Reprogramming State Induced to Face Environmental Stresses [0.03%]
碱性磷酸酶阳性永生小鼠胚胎纤维细胞是环境压力下诱导形成的过渡重编程状态细胞
Monica Evangelista,Mariama El Baroudi,Milena Rizzo et al.
Monica Evangelista et al.
In this study, we report that immortal mouse embryonic fibroblasts (I-MEFs) have a baseline level of cells positive for alkaline phosphatase (AP(+)) staining. Environmental stresses, including long-lasting growth in the absence of expansion...
Aberrant Splicing of Estrogen Receptor, HER2, and CD44 Genes in Breast Cancer [0.03%]
乳腺癌中雌激素受体、HER2和CD44基因的异常剪接
Kazushi Inoue,Elizabeth A Fry
Kazushi Inoue
Breast cancer (BC) is the most common cause of cancer-related death among women under the age of 50 years. Established biomarkers, such as hormone receptors (estrogen receptor [ER]/progesterone receptor) and human epidermal growth factor re...
Csf2 and Ptgs2 Epigenetic Dysregulation in Diabetes-prone Bicongenic B6.NODC11bxC1tb Mice [0.03%]
糖尿病易感连锁导入B6. NOD C11 CX IDO小鼠的Csf2和Ptgs2表观遗传失调
Erin Garrigan,Nicole S Belkin,Federica Seydel et al.
Erin Garrigan et al.
In Type 1 diabetic (T1D) human monocytes, STAT5 aberrantly binds to epigenetic regulatory sites of two proinflammatory genes, CSF2 (encoding granulocyte-macrophage colony-stimulating factor) and PTGS2 (encoding prostaglandin synthase 2/cycl...
Distribution of Angiotensin-1 Converting Enzyme Insertion/Deletion and α-Actinin-3 Codon 577 Polymorphisms in Turkish Male Soccer Players [0.03%]
土耳其男性足球运动员中血管紧张素转换酶插入/缺失和α-actinin-3密码子577多态性分布状况的研究
Korkut Ulucan,Canan Sercan,Türker Biyikli
Korkut Ulucan
Angiotensin-1 converting enzyme (ACE) gene and α-actinin-3 (ACTN3) gene polymorphisms are considered to be the most important candidate genes for genetic predisposition to human athletic performance. In the present study, we aimed to analy...
Maternal stress, preterm birth, and DNA methylation at imprint regulatory sequences in humans [0.03%]
母亲应激、早产及人类基因组印记调控序列DNA甲基化的关系
Adriana C Vidal,Sara E Benjamin Neelon,Ying Liu et al.
Adriana C Vidal et al.
In infants exposed to maternal stress in utero, phenotypic plasticity through epigenetic events may mechanistically explain increased risk of preterm birth (PTB), which confers increased risk for neurodevelopmental disorders, cardiovascular...
Copy Number Variation of TLR-7 Gene and its Association with the Development of Systemic Lupus Erythematosus in Female Patients from Yucatan Mexico [0.03%]
墨西哥尤卡坦女性系统性红斑狼疮患者TLR-7基因拷贝数变异及其与系统性红斑狼疮发病的关系研究
Guillermo Valencia Pacheco,Darig Cámara Cruz,Lizbeth J González Herrera et al.
Guillermo Valencia Pacheco et al.
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the production of autoantibodies against self-antigens, which occurs most often in women between 15 and 40 years of age. The innate immunity is involved in...
Effect of FTO Gene and Physical Activity Interaction on Trunk Fat Percentage Among the Newfoundland Population [0.03%]
FTO基因多态性与身体活动交互作用对 Newfoundland人群腹部脂肪率的影响分析
Anthony Payne,Farrell Cahill,Guang Sun et al.
Anthony Payne et al.
Objective: To explore the effect of FTO gene and physical activity interaction on trunk fat percentage. Design and methods: Subjects ar...
Sarah Heerboth,Karolina Lapinska,Nicole Snyder et al.
Sarah Heerboth et al.
Epigenetic changes such as DNA methylation and histone methylation and acetylation alter gene expression at the level of transcription by upregulating, downregulating, or silencing genes completely. Dysregulation of epigenetic events can be...