Comprehensive Evaluation of Commercial Bisulfite-Based DNA Methylation Kits and Development of an Alternative Protocol With Improved Conversion Performance [0.03%]
商业碱基脱磺酸化法DNA甲基化检测试剂盒的全面评估及高转化性能替代方法的发展
Sascha Tierling,Beate Schmitt,Jörn Walter
Sascha Tierling
DNA methylation is the most studied epigenetic modification with a wide range of regulatory functions in mammalian genomes. It almost exclusively resides on CpG dinucleotides and, among others, plays important roles in early embryo developm...
Association of Tissue-Specific DNA Methylation Alterations with α-Thalassemia Southeast Asian Deletion [0.03%]
东南亚α-地中海贫血缺失型的组织特异性DNA甲基化改变及其相关性研究
Tanapat Pangeson,Phanchana Sanguansermsri,Torpong Sanguansermsri et al.
Tanapat Pangeson et al.
In the wild-type allele, DNA methylation levels of 10 consecutive CpG sites adjacent to the upstream 5'-breakpoint of α-thalassemia Southeast Asian (SEA) deletion are not different between placenta and leukocytes. However, no previous stud...
Epigenetic Regulation of Gene Expression Induced by Butyrate in Colorectal Cancer: Involvement of MicroRNA [0.03%]
丁酸诱导结肠癌细胞中基因表达的表观遗传调控及其microRNA参与性
Karen S Bishop,Huawen Xu,Gareth Marlow
Karen S Bishop
Colorectal cancer (CRC) is the third most common cause of cancer mortality globally. Development of CRC is closely associated with lifestyle, and diet may modulate risk. A Western-style diet is characterised by a high intake of red meat but...
Consistency and Variability of DNA Methylation in Women During Puberty, Young Adulthood, and Pregnancy [0.03%]
女性在青春期、年轻成人期和怀孕期间DNA甲基化的稳定性和变异性
Su Chen,Nandini Mukherjee,Vimala Devi Janjanam et al.
Su Chen et al.
Prior DNA methylation (DNA-m) analyses have identified cytosine-phosphate-guanine (CpG) sites, which show either a significant change or consistency during lifetime. However, the proportion of CpGs that are neither significantly different n...
DNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament [0.03%]
出生时印迹基因调控区域的DNA甲基化与婴儿气质的关系
Bernard F Fuemmeler,Chien-Ti Lee,Adelheid Soubry et al.
Bernard F Fuemmeler et al.
Background: DNA methylation of the differentially methylated regions (DMRs) of imprinted genes is relevant to neurodevelopment. Methods: ...
DNA Methylation of Cellular Retinoic Acid-Binding Proteins in Cervical Cancer [0.03%]
细胞核 retinoic acid 结合蛋白的甲基化与宫颈癌的关系研究
Ana L Arellano-Ortiz,Mauricio Salcedo-Vargas,Claudia L Vargas-Requena et al.
Ana L Arellano-Ortiz et al.
This study determined the methylation status of cellular retinoic acid-binding protein (CRABP) gene promoters and associated them with demographic characteristics, habits, and the presence of human papilloma virus (HPV) in patients with cer...
Wenyi Xu,Fengzhong Wang,Zhongsheng Yu et al.
Wenyi Xu et al.
Living eukaryotic systems evolve delicate cellular mechanisms for responding to various environmental signals. Among them, epigenetic machinery (DNA methylation, histone modifications, microRNAs, etc.) is the hub in transducing external sti...
Jifang Xiao,Daniel H Mai,Liangqi Xie
Jifang Xiao
The rodent naive pluripotent state is believed to represent the preimplantation inner cell mass state of the developing blastocyst and can derive self-renewing pluripotent embryonic stem cells (ESCs) in vitro. Nevertheless, human ESCs exhib...
The Evolution of Epigenetics: From Prokaryotes to Humans and Its Biological Consequences [0.03%]
表观遗传的进化：从原核生物到人类及其生物学后果
Amber Willbanks,Meghan Leary,Molly Greenshields et al.
Amber Willbanks et al.
The evolution process includes genetic alterations that started with prokaryotes and now continues in humans. A distinct difference between prokaryotic chromosomes and eukaryotic chromosomes involves histones. As evolution progressed, genet...
Assessing the Causality Factors in the Association between (Abdominal) Obesity and Physical Activity among the Newfoundland Population-A Mendelian Randomization Analysis [0.03%]
一项针对纽芬兰人口的研究：利用孟德尔随机化分析方法评估肥胖与体力活动之间相关性的因果因素
Frank Barning,Taraneh Abarin
Frank Barning
A total of 1,263 adults from Newfoundland and Labrador were studied in the research. Body mass index (BMI) and percent trunk fat (PTF) were analyzed as biomarkers for obesity. The Mendelian randomization (MR) approach with two single-nucleo...