The Cost Effectiveness of Adjunctive Medical Cannabis Therapy in the Treatment of Moderate Post-Traumatic Stress Disorder [0.03%]
辅助大麻药物治疗在中度创伤后应激障碍治疗中的成本效益分析
Mitchell L Doucette,Dipak Hemraj,D Luke Macfarlan et al.
Mitchell L Doucette et al.
Introduction: Research on the benefits of medical cannabis (MC) is emerging and supports its use as a treatment for post-traumatic stress disorder (PTSD). This study aimed to evaluate the cost effectiveness of MC as an ad...
Economic Model of Uridine Triacetate Versus Supportive Care for the Treatment of Patients with Life-Threatening Early-Onset Severe Toxicity [0.03%]
对于具有生命威胁的早期急性严重毒性的患者，尿苷三乙酸酯与支持治疗的经济模型比较研究
Jorge J Garcia,Alice Beers,Paige Reid et al.
Jorge J Garcia et al.
Background: Early-onset severe toxicity following the administration of 5-fluorouracil (5-FU) or capecitabine occurs in approximately 10-30% of patients receiving fluoropyrimidine therapy in the USA and is fatal to at lea...
Age-Specific Plasma Concentration, Efficacy and Safety of Ciprofol (Cipepofol) for Induction and Maintenance of General Anesthesia in Pediatric Patients Undergoing Elective Surgery: A Single-Arm Prospective, Pragmatic Trial [0.03%]
儿科患者择期手术中不同年龄段的环丙泊酚（Ciprofol）达到全麻诱导和维持的血浆浓度、有效性和安全性：单臂前瞻性实用试验
Zheng Chen,Tuochao Peng,Shuibing Zhang et al.
Zheng Chen et al.
Background and objective: Ciprofol (Cipepofol) currently has well-established clinical research data in adult Chinese patients, but there is a lack of reliable research data in pediatric patients. This study aimed to asse...
Tebentafusp Versus Nivolumab Plus Ipilimumab for Metastatic Uveal Melanoma: An E-Value Sensitivity Analysis Assessing Effect of Unmeasured Confounders on Observational Associations [0.03%]
转移性葡萄膜黑色素瘤中 tebetapusp与nivolumab联合伊匹木单抗的比较：对观察相关性未测量混杂因素影响的E值敏感性分析
Na Zhang,Yu-Wei Qiao,Dan Su et al.
Na Zhang et al.
Dose-Dependent Relationship Between Long-Term Metformin Use and the Risk of Diabetic Retinopathy: A Population-Based Cohort Study [0.03%]
基于人群的队列研究：二甲双胍长期用量与糖尿病视网膜病变风险之间的剂量反应关系
Yu-Ching Li,Kuang-Hua Huang,Yih Yang et al.
Yu-Ching Li et al.
Background and objective: Recent research has raised concerns about the association between metformin treatment in patients with diabetes mellitus (DM) and an increased risk of diabetic retinopathy. We sought to investiga...
Dihydropyrimidine Dehydrogenase Deficiency (DPYD) Genotyping-Guided Fluoropyrimidine-Based Adjuvant Chemotherapy for Breast Cancer. A Cost-Effectiveness Analysis [0.03%]
胸苷磷酸化酶基因型指导的氟尿嘧啶类药物为基础的乳腺癌术后辅助化疗的成本效益分析
Dina Abushanab,Shaban Mohamed,Rania Abdel-Latif et al.
Dina Abushanab et al.
Background and objective: While standard doses of adjuvant fluoropyrimidine-based chemotherapies are generally safe for most patients, the risk of severe adverse drug reactions (ADRs) is increased for those with dihydropy...
Comparison of Pharmacokinetics of Long-Acting Local Analgesics: CPL-01, a Novel Extended-Release Ropivacaine, Demonstrates Consistent and Predictable Exposure Compared with Liposomal Bupivacaine [0.03%]
长效局部麻醉药的药代动力学比较：新型缓释罗哌卡因CPL-01与布比卡因脂质体相比展现出一致和可预测的暴露量
Stevie Pope,Christopher Crean,Sarah Thrasher et al.
Stevie Pope et al.
Background and objective: There is a significant medical need for improved long-acting local anesthetics to decrease postsurgical pain and reduce postoperative opioid use. While ropivacaine is considered a safer local ane...
Assessment of Reperfusion Efficacy of Altelyse Versus Actilyse in Patients with Acute Myocardial Infarction: A Phase 3, Randomized, Double-Blinded, Non-inferiority Clinical Trial [0.03%]
阿替普酶与瑞替普酶再灌注疗效评价急性心肌梗死患者：一项随机、双盲、非劣效性临床试验
Mohammad Reza Beyranvand,Mohammad Asadpour Piranfar,Masoud Solaymani-Dodaran et al.
Mohammad Reza Beyranvand et al.
Background: Primary percutaneous coronary intervention (PPCI) and fibrinolytic or thrombolytic therapy are common treatments for ST-elevation myocardial infarction (STEMI). Primary percutaneous coronary intervention is mo...
Safety, Tolerability, and Pharmacokinetics of a Novel Anti-obesity Agent, S-309309, in Healthy Adults with or Without Obesity [0.03%]
一种新型减肥药物S-309309在肥胖和非肥胖健康成人受试者中的安全性、耐受性和药代动力学：一项随机双盲安慰剂对照试验
Toru Ishibashi,Hideki Tanioka,Tatsuya Ikehara et al.
Toru Ishibashi et al.
Background: Anti-obesity medications are recommended for patients who do not achieve and maintain weight loss despite lifestyle interventions. S-309309 is a novel oral inhibitor of monoacylglycerol O-acyltransferase 2 bei...
Evaluating the Real-World Safety of Icosapent Ethyl Versus Omega-3 Polyunsaturated Fatty Acid in Nationwide US Veterans Cohort: Examining Atrial Fibrillation and Bleeding Endpoints [0.03%]
评估依考超酯与欧米伽-3多不饱和脂肪酸的现实安全性：全国范围美国退伍军人队列中房颤和出血结局的分析
Tanvi Patil,Michael Gregory,Natalie Savona et al.
Tanvi Patil et al.
Purpose: The REDUCE-IT randomized trial demonstrated a cardiovascular benefit of icosapent ethyl (IPE) but also raised potential safety signals for atrial fibrillation (AF) and serious bleeding. We aimed to evaluate the r...