Mucous Membrane Pemphigoid Outcome Measurement in Clinical Research: A Scoping Review [0.03%]
临床研究中粘膜 pemphigoid 评价方法的系统综述性研究
Billal Tedbirt,Eva W H Korte,Marjolein A J Hiel et al.
Billal Tedbirt et al.
Background: Mucous membrane pemphigoid (MMP) is a rare autoimmune bullous disease that predominantly affects mucosae. Treatments for MMP often lack robust evidence and may be poorly tolerated, especially in elderly patien...
Cost-Estimation Model of Prevented Recurrences with Atezolizumab in Early Non-Small-Cell Lung Cancer in Italy [0.03%]
意大利早期非小细胞肺癌使用阿特朱单抗预防复发的成本估算模型
Andrea Marcellusi,Marco Belfiore,Rosaria Tempre et al.
Andrea Marcellusi et al.
Background: Patients with early-stage non-small-cell lung cancer (eNSCLC) often experience disease recurrence after surgery and adjuvant chemotherapy, leading to a substantial clinical and economic burden. The introductio...
Beyond Antihistamines: How Biologic and Small-Molecule Therapies Are Transforming Chronic Spontaneous Urticaria Care in Adults [0.03%]
超越抗组胺药：生物制剂和小分子药物如何变革成人慢性自发性荨麻疹的治疗
Adeeb A Bulkhi
Adeeb A Bulkhi
Chronic urticaria (CU) is a complex, disabling skin disease characterized by recurrent, pruritic wheals and frequently angioedema lasting for 6 weeks or more. Although non-sedating H1-antihistamines remain the first-line therapy, a signific...
Emerging Trends and Future Directions in the Development of Anti-hepatitis B Therapies: A Horizon Scanning Review [0.03%]
抗乙肝病毒药物研发的新趋势和未来方向——地平线扫描研究
Kaijie Yao,Hao Feng,Ying Chen et al.
Kaijie Yao et al.
Background and objectives: Chronic hepatitis B virus infection remains a Major global public health challenge, affecting over 254 million individuals and causing substantial mortality owing to the limited curative potenti...
Effectiveness and Safety of Very-Low-Dose Rosuvastatin-Ezetimibe Therapy in Korean Patients with Dyslipidaemia: A Multicentre Prospective Observational Study [0.03%]
小剂量罗苏伐他汀-依折麦布治疗韩国血脂异常患者的有效性和安全性：一项多中心前瞻性观察研究
Ji Woong Roh,Moon-Hwa Park,Ji-Won Son et al.
Ji Woong Roh et al.
Background and objectives: Dyslipidaemia is a key modifiable risk factor for atherosclerotic cardiovascular disease. However, achieving recommended low-density lipoprotein cholesterol (LDL-C) target levels is challenging ...
Radioligand Therapies (RLTs) and Healthcare System Readiness: From the Experience in GEP-NET, a Retrospective Analysis on DRG and Mobility to Improve the Accessibility to the Future RLT in Italy [0.03%]
放射配体疗法(RLTs)和医疗系统的准备：从GEP-NET的经验，对意大利DRG和可及性的回顾性分析以改善未来RLTs的获取能力
Paolo Sciattella,Matteo Scortichini,Orazio Caffo et al.
Paolo Sciattella et al.
Background and objectives: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a rare diverse group of malignancies, which range from well-differentiated indolent tumors to high-grade aggressive forms. Based on th...
Low-Dose Propranolol versus Amitriptyline for Episodic Migraine Prophylaxis: A Randomized Controlled Trial Assessing Efficacy, Safety, and Cost-Effectiveness [0.03%]
低剂量心得安与阿米替林预防发作性偏头痛的疗效、安全性及成本效益之比较：一项随机对照试验
Vandana Roy,Nasra Banu,Girish Gulab Meshram et al.
Vandana Roy et al.
Background and objectives: Direct head-to-head evidence of propranolol and amitriptyline for migraine prophylaxis is limited. This clinical trial compared the efficacy, safety, and cost-effectiveness of low-dose propranol...
Off-Label Prescription of Benzodiazepines: A Retrospective Cohort Study of Prescribing Prevalence in Primary Care [0.03%]
苯二氮卓类药物的超说明书处方量研究：一项关于初级保健中苯二氮卓类药物处方率的回顾性队列研究
Kevin Trimm,Maria-Teresa Moraga,Bärbel Knäuper et al.
Kevin Trimm et al.
Background and objectives: Benzodiazepines are commonly prescribed medications approved for and used in the treatment of anxiolytic and sleep disorders, as well as for seizures, and alcohol withdrawal. However, benzodiaze...
The Effect of Multiple Oral Doses of a Glycine Transporter 1 Inhibitor, Iclepertin (BI 425809), on the Steady-state Pharmacokinetics of a Combined Oral Contraceptive Containing Ethinylestradiol and Levonorgestrel: a Phase I Clinical Trial in Healthy Females [0.03%]
口服甘氨酸转运蛋白1抑制剂伊克洛铂丁（BI 425809）多次给药对含炔雌醇和左炔诺孕酮复方口服避孕药 steadystate 药代动力学影响的I期临床试验
Shilpa Madari,Yesilda Balavarca,Yury Shatillo et al.
Shilpa Madari et al.
Background: Iclepertin is a selective inhibitor of glycine transporter 1 recently investigated as a novel treatment for cognitive impairment associated with schizophrenia. Iclepertin is a potential mild inducer of liver c...
Revisiting the Role of Serotonin in Attention-Deficit Hyperactivity Disorder: New Insights from Preclinical and Clinical Studies [0.03%]
从临床前和临床研究中重新审视五羟色胺在注意缺陷多动障碍中的作用的新见解
Matia B Solomon,Brittney Yegla,Jeffrey H Newcorn et al.
Matia B Solomon et al.
Attention-deficit hyperactivity disorder (ADHD) is characterized by core symptoms of inattention, hyperactivity, and impulsivity. Aberrant dopaminergic and noradrenergic neurotransmission are often implicated in the pathogenesis of these sy...