Virginia Solitano,Maria Manuela Estevinho,Federica Ungaro et al.
Virginia Solitano et al.
Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), remains challenging to manage, with a substantial proportion of patients not responding to conventional therapies or developing complications. ...
Interleukin-23 versus Interleukin-17 Inhibitors in Preventing Incidental Psoriatic Arthritis in Patients with Psoriasis: A Real-World Comparison From the TriNetX US Collaborative Network [0.03%]
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Sebastian Yu,An-Ping Huo,Yu-Hsun Wang et al.
Sebastian Yu et al.
Background: Psoriatic arthritis (PsA) is a common comorbidity in patients with psoriasis (PsO) that leads to significant disease burden. Biologic therapies targeting the interleukin (IL)-23/IL-17 axis have been widely use...
An Automated Tool for Glycosimilarity Assessment of mAb Therapeutic Biosimilars: Trastuzumab and Bevacizumab as Case Studies [0.03%]
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Anuj Shrivastava,Sanjeet S Patil,Rohan Shah et al.
Anuj Shrivastava et al.
Background: With the expiration of patents for multiple biotherapeutics, biosimilars are gaining traction globally as cost-effective alternatives to the original products. Glycosylation, a critical quality attribute, make...
New and Emerging Biological Therapies for Myasthenia Gravis: A Focussed Review for Clinical Decision-Making [0.03%]
重症肌无力的新型及新兴生物制剂疗法：临床决策导向性回顾
Lea Gerischer,Paolo Doksani,Sarah Hoffmann et al.
Lea Gerischer et al.
Myasthenia gravis (MG) is a rare autoimmune disease characterised by exertion-induced muscle weakness that can lead to potentially life-threatening myasthenic crises. Detectable antibodies are directed against specific postsynaptic structur...
State-of-the-Art Liver Cancer Organoids: Modeling Cancer Stem Cell Heterogeneity for Personalized Treatment [0.03%]
肝脏癌症类器官的最前沿研究：模拟癌症干细胞异质性以实现个性化治疗
Julien Giron-Michel,Maël Padelli,Estelle Oberlin et al.
Julien Giron-Michel et al.
Liver cancer poses a global health challenge with limited therapeutic options. Notably, the limited success of current therapies in patients with primary liver cancers (PLCs) may be attributed to the high heterogeneity of both hepatocellula...
Correction: Dystrophin- and Utrophin-Based Therapeutic Approaches for Treatment of Duchenne Muscular Dystrophy: A Comparative Review [0.03%]
关于杜氏肌营养不良症的抗肌萎缩蛋白和乌托芬治疗策略的比较研究的更正通知
Sylwia Szwec,Zuzanna Kapłucha,Jeffrey S Chamberlain et al.
Sylwia Szwec et al.
Jérôme Avouac,Marc Scherlinger;Club for Innovative Immunotherapies in Immune-Mediated Inflammatory Diseases (CI)
Jérôme Avouac
Chimeric antigen receptor (CAR) T-cell therapy, initially successful in treating hematological malignancies, is emerging as a potential treatment for autoimmune diseases, including rheumatic conditions. CAR T cells, engineered to target and...
Correction: Monoclonal Antibody Generation Using Single B Cell Screening for Treating Infectious Diseases [0.03%]
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John S Schardt,Neelan S Sivaneri,Peter M Tessier
John S Schardt
Mark Kacar,Adam Al-Hakim,Sinisa Savic
Mark Kacar
B-cell depleting therapy (BCDT) has revolutionised the treatment of B-cell malignancies and autoimmune diseases by targeting specific B-cell surface antigens, receptors, ligands, and signalling pathways. This narrative review explores the m...
The Evolving Applications of Bispecific Antibodies: Reaping the Harvest of Early Sowing and Planting New Seeds [0.03%]
双特异抗体的演变及应用：收获早期播种的果实并播撒新的种子
Diego A Ellerman
Diego A Ellerman
After decades of gradual progress from conceptualization to early clinical trials (1960-2000), the therapeutic potential of bispecific antibodies (bisp Abs) is now being fully realized. Insights gained from both successful and unsuccessful ...