Association of periodontitis with rheumatoid arthritis and atherosclerosis: Novel paradigms in etiopathogeneses and management? [0.03%]
牙周炎与类风湿关节炎和动脉粥样硬化的关系：病因及治疗的新理念？
Mena Soory
Mena Soory
There is increasing documentation of a link between inflammatory periodontal disease affecting the supporting structure of teeth, rheumatoid arthritis, and coronary artery disease. Periodontitis is initiated predominantly by Gram-negative b...
Advances in diagnostic and treatment options in patients with fibromyalgia syndrome [0.03%]
纤维肌痛综合征的诊断和治疗选项的进展
Ali Gur,Pelin Oktayoglu
Ali Gur
Fibromyalgia (FM) is characterized as a chronic, painful, noninflammatory syndrome affecting the musculoskeletal system. In addition to pain, common co-morbid symptoms associated with FM include sleep disturbances, fatigue, morning stiffnes...
Jessica A Stanich,John D Carter,Judith Whittum-Hudson et al.
Jessica A Stanich et al.
Rheumatoid arthritis (RA) has been described in the medical literature for over two hundred years, but its etiology remains unknown. RA displays phenotypic heterogeneity, and it is a relatively prevalent clinical entity: it affects approxim...
Bioboosters in the treatment of rheumatic diseases: a comprehensive review of currently available biologics in patients with rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis [0.03%]
生物制剂治疗风湿性疾病：类风湿关节炎、强直性脊柱炎和银屑病关节炎患者目前可用的生物制剂全面回顾
Fabrizio Cantini,Carlotta Nannini,Laura Niccoli
Fabrizio Cantini
Immunologic research has clarified many aspects of the pathogenesis of inflammatory rheumatic disorders. Biologic drugs acting on different steps of the immune response, including cytokines, B- and T-cell lymphocytes, have been marketed ove...
Basic fibroblast growth factor induces matrix metalloproteinase-13 via ERK MAP kinase-altered phosphorylation and sumoylation of Elk-1 in human adult articular chondrocytes [0.03%]
基础成纤维细胞生长因子通过ERK MAP激酶诱导人关节软骨细胞中Elk-1的磷酸化和泛素样修饰sumoylation来调节基质金属蛋白酶-13
Hee-Jeong Im,Andrew D Sharrocks,Xia Lin et al.
Hee-Jeong Im et al.
Degradation of the extracellular matrix (ECM) by matrix metalloproteinases (MMPs) and release of basic fibroblast growth factor (bFGF) are principal aspects of the pathology of osteoarthritis (OA). ECM disruption leads to bFGF release, whic...
Charles J Malemud
Charles J Malemud
Recent advances in understanding the mechanism(s) of how IL-6 trans-signaling regulates immune cell function and promotes inflammation in autoimmune arthritis are critically reviewed. Serum and/or synovial fluid (SF) IL-6 is markedly elevat...
The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases [0.03%]
ADAMTS-7和ADAMTS-12基质金属蛋白酶的新功能角色
Edward A Lin,Chuan-Ju Liu
Edward A Lin
The a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) comprise a family of secreted zinc metalloproteinases with a precisely ordered modular organization. These enzymes play an important role in the turnover of extrace...
Daniela Merlotti,Luigi Gennari,Giuseppe Martini et al.
Daniela Merlotti et al.
Paget's disease of bone (PDB) is a chronic bone remodelling disorder characterized by increased osteoclast-mediated bone resorption, with subsequent compensatory increases in new bone formation, resulting in a disorganized mosaic of woven a...
The clinical efficacy and safety of certolizumab pegol (CZP) in the treatment of rheumatoid arthritis: focus on long-term use, patient considerations and the impact on quality of life [0.03%]
赛妥珠单抗（CZP）治疗类风湿性关节炎的临床疗效和安全性：长期使用的关注点、患者考虑及对生活质量的影响
Roy Fleischmann
Roy Fleischmann
Rheumatoid arthritis can cause chronic pain, disability, fatigue and loss of productivity both in the workplace and at home. Fatigue, not joint pain, swelling or that there may be radiographic damage, is frequently mentioned by patients as ...
Update on the use of rituximab for intractable rheumatoid arthritis [0.03%]
利妥昔单抗治疗难治性类风湿关节炎的疗效总结及教训
R John Looney
R John Looney
It has been 3 years since rituximab, a mouse x human chimeric anti-CD20 monoclonal antibody that selectively depleted B cells, was approved by the FDA for the treatment of moderate to severe rheumatoid arthritis (RA) with an inadequate resp...