Mind the Gaps: Literature Survey Reveals Shortcomings in Handling Missing Data in Clinical Practice Research Datalink (CPRD), a UK Primary Care Health Records Database [0.03%]
关注缺失：文献调查揭示了临床实践研究数据链（CPRD）中处理缺失数据的不足之处，CPRD是英国初级保健健康记录数据库
Esther Tolani,Miriam Rachel Carpenter,Irene Petersen et al.
Esther Tolani et al.
Background: In the United Kingdom (UK) primary care electronic health records (EHR), key demographic, clinical, and lifestyle variables such as ethnicity, social deprivation, body mass index and smoking status are often i...
Can Contemporary Large Language Models Provide the Domain Knowledge Needed for Causal Inference? Evaluating Automated Causal Graph Discovery Through an ASCVD Case Study [0.03%]
当代大型语言模型能否提供因果推理所需的领域知识？通过ASCVD案例研究评估自动因果图发现能力
Maryam Aziz,M Alan Brookhart
Maryam Aziz
Purpose: Directed acyclic graphs (DAGs) are critical in epidemiology and public health research for guiding study design and minimizing bias. Yet, developing DAGs for causal inference requires substantial domain knowledge...
Aidan G O&#x;Keeffe,Irene Petersen
Aidan G O&#x;Keeffe
Quasi-experimental approaches are used routinely in clinical epidemiological research to enable causal treatment/intervention effect estimation from observational data. One such approach is the regression discontinuity design (RDD): a metho...
Vahe Khachadourian,Magdalena Janecka
Vahe Khachadourian
Introduction: Comorbidity between disorders is pervasive, and its relationship to the main conditions under investigation needs to be addressed for robust causal inference. However, many clinical etiologic studies still f...
Design and Protocol of the Biobank for Metabolic Syndrome Consequences (BMSC): A Prospective Cohort Study in Northwest China [0.03%]
中国西北地区代谢综合征队列研究（BMSC）的设计与方案
Xue Yang,Qian Li,Yayi He et al.
Xue Yang et al.
This manuscript describes the design and protocol of the Biobank for Metabolic Syndrome Consequences (BMSC), a prospective cohort study in Northwest China. Metabolic syndrome (MetS) is characterized by a group of interrelated disorders, inc...
Light to Moderate Alcohol Consumption and Cancer Incidence: The Norwegian Women and Health Cohort Study [0.03%]
适量饮酒与癌症发病率的关系：挪威妇女与健康队列研究
Fjorida Llaha,Idlir Licaj,Ekaterina Sharashova et al.
Fjorida Llaha et al.
Purpose: To investigate the impact of light-moderate (up to 20 g/day) alcohol consumption on incidence of postmenopausal breast, kidney, lung, pancreatic, colorectal, postmenopausal ovarian and postmenopausal endometrial ...
Sodium-Glucose Cotransporter 2 Inhibitors and Lower Risk of Depression in Population with Type 2 Diabetes Mellitus: A Population-Based Active Comparator, New-User Design [0.03%]
钠葡萄糖共转运蛋白2抑制剂与2型糖尿病患者较低的抑郁风险：基于人群的活性对照药，新用户设计研究
Ming-Jyun Kao,Ying-Chih Huang,Yu-Chieh Huang et al.
Ming-Jyun Kao et al.
Purpose: This study aimed to investigate the association between the use of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and the risk of developing depression in patients with type 2 diabetes mellitus. ...
Association Between Pneumonia Risk and Anticholinergic Burden Among Patients with Different Frailty Levels [0.03%]
不同虚弱程度患者肺炎风险与抗胆碱作用负担之间的关系
Avery Shuei-He Yang,Hsin-Yu Fan Chiang,Daniel Hsiang-Te Tsai et al.
Avery Shuei-He Yang et al.
Objective: We aimed to evaluate the association between recent increase in anticholinergic burden and risk of hospitalised pneumonia, taking frailty levels into consideration. ...
Sophie M Selbe,Péter Szentkúti,Travis C Evans et al.
Sophie M Selbe et al.
Purpose: Evidence suggests there may be a protective association between some antihypertensive medications and posttraumatic stress disorder (PTSD) incidence, but few samples are large enough to examine sex differences in...
Post-Marketing Safety Concerns with Efgartigimod alfa: A Pharmacovigilance Analysis Based on the Food and Drug Administration Adverse Event Reporting System Database [0.03%]
依加替吉奥 Alfaa 药物警戒分析：基于美国食品药品监督管理局不良事件报告系统数据库的上市后安全性问题研究
Jinlong Huang,Hanyun Ye,Jingyang Lin et al.
Jinlong Huang et al.
Aim: Efgartigimod alfa (EA) is a novel US Food and Drug Administration (FDA) approved neonatal Fc receptor-targeting drug; however, its real-world adverse event (AE) profile remains underexplored. ...