Cardiovascular Risks of Aromatase Inhibitors versus Tamoxifen in Postmenopausal Breast Cancer: A Multinational Cohort Study [0.03%]
来雌拮抗剂与他莫昔芬对绝经后乳腺癌患者心血管风险的比较：一项跨国队列研究
Shu-Chen Hu,Charles E Gaber,Chiao Lo et al.
Shu-Chen Hu et al.
Background: Aromatase inhibitors (AIs) are the preferred treatment for postmenopausal women with hormone receptor-positive (HR+) breast cancer, but their cardiovascular safety remains uncertain. This study compared cardio...
Development and External Validation of Machine Learning Model to Predict Live Birth Following Assisted Reproductive Technology in Women with Ovarian Endometriomas: A Decision-Support Tool [0.03%]
机器学习模型的开发和外部验证，以预测卵巢子宫内膜异位囊肿女性通过辅助生殖技术成功活产：一种决策支持工具
Yifei Sun,Zijing Wang,Jiayi Zhou et al.
Yifei Sun et al.
Background: Ovarian endometriomas damage the ovarian structure, alter ovarian inflammation, and impair ovarian reserve. Given the conflicting results, determining an optimal reproductive strategy for women with endometrio...
Holly Christina Smith,Juan Carlos Bazo-Alvarez,Louise Pinder et al.
Holly Christina Smith et al.
IQVIA Medical Research Data (IMRD) was established to be used for population-based research to provide insights into primary care managed diseases and treatments to help inform healthcare decisions and improve patient outcomes. Uses include...
Real-World Comparability of Antiresorptive Osteoporosis Treatment Groups Among Treatment-Naïve and Treatment-Experienced Women Ages 55 and Older in the United States [0.03%]
美国绝经后妇女抗吸收骨质疏松症治疗组的现实世界可比性研究：初治与复治患者年龄≥55岁
Kathleen E Hurwitz,Lydia Feinstein,David A Pritchard et al.
Kathleen E Hurwitz et al.
Purpose: Selection of osteoporosis (OP) treatment is affected by patients' disease severity and fracture risk, potentially confounding real-world comparative effectiveness and safety studies of antiresorptive medications....
Implementation of Day Surgery in Denmark Compared with Benchmarks from the United Kingdom: A Nationwide Register-Based Cohort Study [0.03%]
丹麦日间手术实施情况与英国基准的对比：全国登记队列研究
Kathrine Hald,Jakob Nebeling Hedegaard,John Asger Petersen et al.
Kathrine Hald et al.
Background: Day surgery is a safe and cost-effective alternative to inpatient surgery, and the British Association of Day Surgery (BADS) has developed national benchmarks which provide recommended day surgery case rates t...
Harmonizing Case Validation for Vaccine Safety in Real-World Data: The VAC4EU Experience [0.03%]
基于真实世界数据的疫苗安全性案例验证的统合：VAC4EU项目的经验
Amirreza Dehghan Tarazjani,Daniel Weibel,Taylor Aurelius et al.
Amirreza Dehghan Tarazjani et al.
Purpose: Applying standardized Brighton Collaboration (BC) case definitions retrospectively to heterogeneous real-world data (RWD) is challenging due to inconsistent clinical detail and data structures across settings. To...
Timing of Core Sepsis Bundle Elements Initiation in Critically Ill Patients: A Multicenter Target Trial Emulation Study [0.03%]
重症患者核心脓毒症管理包启动时间：多中心目标试验模拟研究
Mingxia Li,Jiaqi Zhang,Haozhao Huang et al.
Mingxia Li et al.
Purpose: One-hour sepsis bundle was developed in 2018. However, the optimal timing for antibiotic, fluid resuscitation, and vasopressor initiation in intensive care units (ICUs) remains debated. High-quality randomized ev...
Prevalence and Incidence of Treatment-Range Adolescent Idiopathic Scoliosis Diagnosed in Ontario Between 2012 and 2021: Validating a Population-Based Health Administrative Algorithm for Case Identification in Youth Aged 10-17 Years [0.03%]
2012年至2021年安大略省青少年特发性脊柱侧弯的患病率和发病率：在10-17岁青年中验证基于人群的健康管理算法以识别病例
Jennifer A Dermott,Teresa To,Liisa Jaakkimainen et al.
Jennifer A Dermott et al.
Purpose: The purpose of this study is to estimate the prevalence and incidence of treatment-range adolescent idiopathic scoliosis (≥20°) over 10-years in Ontario youth 10-17 years of age, by validating a population-base...
Henrik Toft Sørensen,Erzsébet Horváth-Puhó,Janet L Peacock
Henrik Toft Sørensen
Competing risks arise when people are at risk of multiple mutually exclusive events, such that the occurrence of one event alters the probability of others. In research, ignoring competing risks can lead to biased estimates. We outline key ...
Risks of Myocardial Infarction and Mortality in Patients with Incident Rheumatoid Arthritis Compared with a Matched General Population: A Danish Nationwide Cohort Study [0.03%]
与普通人群相比，新发类风湿关节炎患者的心肌梗死和死亡风险：一项丹麦全国队列研究
Brian Bridal Løgstrup,Torkell Ellingsen,Alma B Pedersen et al.
Brian Bridal Løgstrup et al.
Background and aims: Rheumatoid arthritis (RA) is increasingly being recognized as cardiovascular risk factor. We examined temporal trends in the risks of myocardial infarction (MI) and all-cause mortality in patients wit...