Therapeutic Potential of Ion Carrier Antibiotics in Ovarian Cancer: Mechanisms and Prospects [0.03%]
离子载体抗生素在卵巢癌治疗中的潜力：机制与前景
Li Feng,Wang Wen,Yao Shujuan
Li Feng
With over two-thirds of cases diagnosed at advanced stages, ovarian cancer is the deadliest gynecological cancer. In 70% of patients receiving standardized treatment, recurrence happens within 12-24 months, leading to a 5-year survival rate...
Deficient Mismatch Repair Subtypes in Vietnamese Colorectal Cancer: Clinicopathologic Associations, Predictive Modeling, and IHC-PCR Concordance [0.03%]
越南结直肠癌错配修复缺陷亚型的临床病理特征、预测建模和IHC-PCR一致性研究
Hoang Duc Trinh,Quoc Thang Pham,Nguyen Hong Phong et al.
Hoang Duc Trinh et al.
Background: Microsatellite instability (MSI) caused by deficient mismatch repair (dMMR) influences prognosis and immunotherapy response in colorectal cancer. The dMMR phenotype includes MutL-deficient (dMutL) and MutS-def...
Evaluation of DNA Methylation in TAC1, SOX17, and RASSF1A for the Early Diagnosis of Lung Cancer [0.03%]
TAC1、SOX17和RASSF1A甲基化在肺癌早期诊断中的价值评估研究
Huan Wang,Teng Zhang,Liqun Li et al.
Huan Wang et al.
Background: Low-Dose Computed Tomography (LDCT) is commonly used to detect pulmonary nodules; however, it may also contribute to overdiagnosis. DNA methylation shows promise as an approach to discriminate early-stage lung...
Preoperative Prognostic Nutritional Index Predicts Postoperative Outcomes in Colorectal Cancer: A Propensity Score-Matched Cohort Study [0.03%]
术前预后营养指数可预测结直肠癌术后结果：一项倾向性匹配队列研究
Chew-Teng Kor,Tsung-Jung Tsai,Tsung Chuang et al.
Chew-Teng Kor et al.
Background: The Prognostic Nutritional Index (PNI) is a numerical score used to assess the nutritional and immunological status, derived from serum albumin concentration and lymphocyte count. While malnutrition and system...
Parameters That May Predict NAC Effectiveness in Hormone-Positive Breast Cancer According to CPS Score [0.03%]
根据CPS评分，可能预测荷阳性乳腺癌NAC疗效的参数
Mehmet Emin Buyukbayram,Zekeriya Hannarici,Aykut Turhan et al.
Mehmet Emin Buyukbayram et al.
Objective: Neoadjuvant chemotherapy (NAC) in hormone-positive operable breast cancer supports breast-conserving surgery, axillary dissection, and survival. However, the pathological complete response (pCR) rates to NAC in...
Synergistic Effects of Morin and Doxorubicin Overcome Chemoresistance in Ovarian Cancer: Preclinical Insights From in vitro and in vivo Models [0.03%]
山柰酚联合多柔比星克服卵巢癌化疗耐药的协同效应：来自体外和体内模型的临床前见解
Ruihua Wu,Amirabas Bostani,Junmei Wang
Ruihua Wu
Background: Epithelial ovarian cancer (EOC) remains highly lethal due to late-stage diagnosis and chemoresistance, necessitating strategies to enhance conventional therapies like doxorubicin (DOX) while mitigating toxicit...
Primary Mucosal Routes of Opioid Administration for Treating Terminal Cancer Pain: Rectal, Buccal, and Intranasal Delivery [0.03%]
用于终末期癌症疼痛治疗的阿片类药物主要粘膜给药途径：直肠、颊侧和鼻腔内给药
Xiao-Yi Huang,Qiang Qi,Cheng-Shan Zhang et al.
Xiao-Yi Huang et al.
Purpose: This review analyzes the factors influencing mucosal administration of opioids, the methods of administration, clinical applications, pharmacokinetic parameters, and considerations. ...
Combined Use of Radioactive 125I Seeds and PD-1 Inhibitor Provides Sustained Clinical Benefit in an Elderly Patient with Advanced Non-Small Cell Lung Cancer: A Case Report [0.03%]
放射性碘125I粒子与PD-1抑制剂联合应用使一位晚期肺腺癌患者获益：一例报告
Su-Rui Ouyang,Xuan-Zhen Bao,Yi-Ping Li et al.
Su-Rui Ouyang et al.
Radioactive 125I seed implantation, a minimally invasive and targeted local therapy, is particularly suitable for elderly patients who are ineligible for conventional treatments. Meanwhile, PD-1 inhibitors, as a major focus of current resea...
Neoadjuvant Chemoimmunotherapy for the Treatment of Locally Advanced Nasopharyngeal Carcinoma in Non-Endemic Regions: A Single-Arm Phase 2 Clinical Trial [0.03%]
非流行地区局部晚期鼻咽癌新辅助化疗免疫治疗单臂二期临床试验
Lingran Zhou,Zhenchao Tao,Yan Zhou et al.
Lingran Zhou et al.
Background and purpose: Nasopharyngeal carcinoma (NPC) is a malignancy with distinct geographical distribution and is rare in non-endemic regions. Despite significant improvements in NPC survival through chemoradiotherapy...
Clinical Trial
Cancer management and research. 2026 Jan 15:18:559229. DOI:10.2147/CMAR.S559229 2026
Targeting Oncogenic miRNAs in NSCLC: Therapeutic Strategies and Emerging Approaches [0.03%]
靶向NSCLC中的致癌miRNA：治疗策略与新兴方法
Huimin Su,Yuanyuan Zou
Huimin Su
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related deaths globally, with poor prognosis in advanced stages despite therapeutic advances. MicroRNAs (miRNAs) play a critical role in NSCLC pathogenesis, acting as tumo...